This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Auranofin
catalog :
A6733
citations: 116
Reference
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Tian S, Siu F, Lok C, Fung Y, Che C. Anticancer auranofin engages 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) as a target. Metallomics. 2019;11:1925-1936 pubmed publisher
Mi ichi F, Ishikawa T, Tam V, Deloer S, Hamano S, Hamada T, et al. Characterization of Entamoeba histolytica adenosine 5'-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis. PLoS Negl Trop Dis. 2019;13:e0007633 pubmed publisher
Diaz R, Shytaj I, Giron L, Obermaier B, Della Libera E, Galinskas J, et al. Potential impact of the antirheumatic agent auranofin on proviral HIV-1 DNA in individuals under intensified antiretroviral therapy: Results from a randomised clinical trial. Int J Antimicrob Agents. 2019;54:592-600 pubmed publisher
Tharmalingam N, Ribeiro N, da Silva D, Naik M, Cruz L, Kim W, et al. Auranofin is an effective agent against clinical isolates of Staphylococcus aureus. Future Med Chem. 2019;11:1417-1425 pubmed publisher
Thome T, Salyers Z, Kumar R, Hahn D, Berru F, Ferreira L, et al. Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol. 2019;317:C701-C713 pubmed publisher
Li X, Zhang B, Yan C, Li J, Wang S, Wei X, et al. A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage. Nat Commun. 2019;10:2745 pubmed publisher
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Ward D, van de Langemheen H, Koehne E, Kreidenweiss A, Liskamp R. Highly tunable thiosulfonates as a novel class of cysteine protease inhibitors with anti-parasitic activity against Schistosoma mansoni. Bioorg Med Chem. 2019;: pubmed publisher
Xu H, Li C, Mozziconacci O, Zhu R, Xu Y, Tang Y, et al. Xanthine oxidase-mediated oxidative stress promotes cancer cell-specific apoptosis. Free Radic Biol Med. 2019;: pubmed publisher
Jang H, Eom Y. Repurposing auranofin to combat uropathogenic Escherichia coli biofilms. J Appl Microbiol. 2019;127:459-471 pubmed publisher
Kuo D, Ding J, Cohn I, Zhang F, Wei K, Rao D, et al. HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness. Sci Transl Med. 2019;11: pubmed publisher
Rajavel T, Banu Priya G, Suryanarayanan V, Singh S, Pandima Devi K. Daucosterol disturbs redox homeostasis and elicits oxidative-stress mediated apoptosis in A549 cells via targeting thioredoxin reductase by a p53 dependent mechanism. Eur J Pharmacol. 2019;855:112-123 pubmed publisher
Skaga E, Skaga I, Grieg Z, Sandberg C, Langmoen I, Vik Mo E. The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy. J Cancer Res Clin Oncol. 2019;145:1495-1507 pubmed publisher
Zhang X, Selvaraju K, Saei A, D Arcy P, Zubarev R, Arnér E, et al. Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug. Biochimie. 2019;162:46-54 pubmed publisher
Nag D, Bhanja P, Riha R, Sanchez Guerrero G, Kimler B, Tsue T, et al. Auranofin Protects Intestine against Radiation Injury by Modulating p53/p21 Pathway and Radiosensitizes Human Colon Tumor. Clin Cancer Res. 2019;: pubmed publisher
Fidyt K, Pastorczak A, Góral A, Szczygiel K, Fendler W, Muchowicz A, et al. Targeting the thioredoxin system as a novel strategy against B-cell acute lymphoblastic leukemia. Mol Oncol. 2019;13:1180-1195 pubmed publisher
Elhassanny A, Ladin D, Soliman E, Albassam H, Morris A, Kobet R, et al. Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants. Prostaglandins Other Lipid Mediat. 2019;142:9-23 pubmed publisher
Liu X, Wang W, Yin Y, Li M, Li H, Xiang H, et al. A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer. Invest New Drugs. 2019;: pubmed publisher
Mao Z, Huang Y, Zhang Z, Yang X, Zhang X, Huang Y, et al. Pharmacological levels of hydrogen sulfide inhibit oxidative cell injury through regulating the redox state of thioredoxin. Free Radic Biol Med. 2019;134:190-199 pubmed publisher
Chen X, Chen X, Zhang X, Wang L, Cao P, Rajamanickam V, et al. Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells. Redox Biol. 2019;21:101061 pubmed publisher
Shokhina A, Kostyuk A, Ermakova Y, Panova A, Staroverov D, Egorov E, et al. Red fluorescent redox-sensitive biosensor Grx1-roCherry. Redox Biol. 2019;21:101071 pubmed publisher
Abdelkhalek A, Abutaleb N, Mohammad H, Seleem M. Antibacterial and antivirulence activities of auranofin against Clostridium difficile. Int J Antimicrob Agents. 2019;53:54-62 pubmed publisher
Turcano L, Torrente E, Missineo A, Andreini M, Gramiccia M, Di Muccio T, et al. Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening. PLoS Negl Trop Dis. 2018;12:e0006969 pubmed publisher
Cecchinato V, D Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, et al. Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis. Front Immunol. 2018;9:2118 pubmed publisher
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Mi ichi F, Miyake Y, Tam V, Yoshida H. A Flow Cytometry Method for Dissecting the Cell Differentiation Process of Entamoeba Encystation. Front Cell Infect Microbiol. 2018;8:250 pubmed publisher
Hu J, Zhang H, Cao M, Wang L, Wu S, Fang B. Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma. Mol Cancer Ther. 2018;17:2156-2163 pubmed publisher
Dunigan K, Li Q, Li R, Locy M, Wall S, Tipple T. The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2018;315:L545-L552 pubmed publisher
Hasam Henderson L, Gotti G, Mishto M, Klisch C, Gerevich Z, Geiger J, et al. NMDA-receptor inhibition and oxidative stress during hippocampal maturation differentially alter parvalbumin expression and gamma-band activity. Sci Rep. 2018;8:9545 pubmed publisher
Fernandez M, O Flaherty C. Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa. Hum Reprod. 2018;33:1394-1407 pubmed publisher
Chortis V, Taylor A, Doig C, Walsh M, Meimaridou E, Jenkinson C, et al. Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma. Endocrinology. 2018;159:2836-2849 pubmed publisher
Abdelkhalek A, Abutaleb N, Elmagarmid K, Seleem M. Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci. Sci Rep. 2018;8:8353 pubmed publisher
Kamunde C, Sharaf M, MacDonald N. H2O2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems. Free Radic Biol Med. 2018;124:135-148 pubmed publisher
Elie B, Pechenyy Y, Uddin F, Contel M. A heterometallic ruthenium-gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated proteases in renal cancer. J Biol Inorg Chem. 2018;23:399-411 pubmed publisher
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Carroll B, Otten E, Manni D, Stefanatos R, Menzies F, Smith G, et al. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat Commun. 2018;9:256 pubmed publisher
Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, et al. Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018;172:409-422.e21 pubmed publisher
Xiao J, Rijal P, Schimanski L, Tharkeshwar A, Wright E, Annaert W, et al. Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein. J Virol. 2018;92: pubmed publisher
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Schultz M, Diaz A, Smite S, Lay A, DeCant B, McKinney R, et al. Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer. Oncotarget. 2017;8:92667-92681 pubmed publisher
Baek H, Park N, Kwon Y, Ye D, Shin S, Chun Y. Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-?-nuclear factor-?B signaling pathway in prostate cancer cells. Oncotarget. 2017;8:74263-74275 pubmed publisher
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Malone C, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, et al. mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. Cancer Discov. 2017;7:1450-1463 pubmed publisher
Leitsch D. Drug susceptibility testing in microaerophilic parasites: Cysteine strongly affects the effectivities of metronidazole and auranofin, a novel and promising antimicrobial. Int J Parasitol Drugs Drug Resist. 2017;7:321-327 pubmed publisher
Hall S, Toulany J, Bennett L, Martinez Farina C, Robertson A, Jakeman D, et al. Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells. J Pharmacol Exp Ther. 2017;363:196-210 pubmed publisher
Karwaciak I, Gorzkiewicz M, Bartosz G, Pulaski L. TLR2 activation induces antioxidant defence in human monocyte-macrophage cell line models. Oncotarget. 2017;8:54243-54264 pubmed publisher
Sajman J, Trus M, Atlas D, Sherman E. The L-type Voltage-Gated Calcium Channel co-localizes with Syntaxin 1A in nano-clusters at the plasma membrane. Sci Rep. 2017;7:11350 pubmed publisher
Narayan S, Nishtala P. Development and validation of a Medicines Comorbidity Index for older people. Eur J Clin Pharmacol. 2017;73:1665-1672 pubmed publisher
Bae J, Lee J, Park Y, Park K, Kim J, Cho D, et al. Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells. Oncol Rep. 2017;38:2417-2425 pubmed publisher
Trommenschlager A, Chotard F, Bertrand B, Amor S, Dondaine L, Picquet M, et al. Gold(i)-BODIPY-imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents. Dalton Trans. 2017;46:8051-8056 pubmed publisher
Lee J, Kwon Y, Baek H, Ye D, Cho E, Choi H, et al. Synergistic induction of apoptosis by combination treatment with mesupron and auranofin in human breast cancer cells. Arch Pharm Res. 2017;40:746-759 pubmed publisher
Jelcic M, Enyedi B, Xavier J, Niethammer P. Image-Based Measurement of H2O2 Reaction-Diffusion in Wounded Zebrafish Larvae. Biophys J. 2017;112:2011-2018 pubmed publisher
Nagakannan P, Eftekharpour E. Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells. Free Radic Biol Med. 2017;108:819-831 pubmed publisher
Sciegienka S, Solst S, Falls K, Schoenfeld J, Klinger A, Ross N, et al. D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress. Free Radic Biol Med. 2017;108:354-361 pubmed publisher
Kipp A, Deubel S, Arnér E, Johansson K. Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells. Redox Biol. 2017;12:403-409 pubmed publisher
Oh B, Lee S, Cho H, Park Y, Kim J, Yoon S, et al. Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer. Cell Death Dis. 2017;8:e2682 pubmed publisher
Massai L, Messori L, Micale N, Schirmeister T, Maes L, Fregona D, et al. Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents. Biometals. 2017;30:313-320 pubmed publisher
Hwang Bo H, Jeong J, Han M, Park C, Hong S, Kim G, et al. Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species. Gen Physiol Biophys. 2017;36:117-128 pubmed publisher
Kang J, Kim G, Kim B, Choi Y. Antioxidative effects of diallyl trisulfide on hydrogen peroxide-induced cytotoxicity through regulation of nuclear factor-E2-related factor-mediated thioredoxin reductase 1 expression in C2C12 skeletal muscle myoblast cells. Gen Physiol Biophys. 2017;36:129-139 pubmed publisher
Warzajtis B, Glišić B, Savić N, Pavic A, Vojnovic S, Veselinović A, et al. Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion. Dalton Trans. 2017;46:2594-2608 pubmed publisher
Poet G, Oka O, van Lith M, Cao Z, Robinson P, Pringle M, et al. Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER. EMBO J. 2017;36:693-702 pubmed publisher
Suzuki S, Ogawa M, Ohta S, Nunomura S, Nanri Y, Shiraishi H, et al. Induction of Airway Allergic Inflammation by Hypothiocyanite via Epithelial Cells. J Biol Chem. 2016;291:27219-27227 pubmed publisher
Chen X, Tzekov R, Su M, Hong H, Min W, Han A, et al. Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. PLoS ONE. 2016;11:e0166386 pubmed publisher
Zhang J, Yao J, Peng S, Li X, Fang J. Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase. Biochim Biophys Acta Mol Basis Dis. 2017;1863:129-138 pubmed publisher
Filipczak P, Thomas C, Chen W, Salzman A, McDonald J, Lin Y, et al. TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade. Cancer Res. 2016;76:7130-7139 pubmed
Roh J, Jang H, Kim E, Shin D. Targeting of the Glutathione, Thioredoxin, and Nrf2 Antioxidant Systems in Head and Neck Cancer. Antioxid Redox Signal. 2017;27:106-114 pubmed publisher
Nagakannan P, Iqbal M, Yeung A, Thliveris J, Rastegar M, Ghavami S, et al. Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells. Free Radic Biol Med. 2016;101:53-70 pubmed publisher
Leitsch D, Muller J, Muller N. Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target. Int J Parasitol Drugs Drug Resist. 2016;6:148-153 pubmed publisher
Thangamani S, Mohammad H, Abushahba M, Sobreira T, Hedrick V, PAUL L, et al. Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens. Sci Rep. 2016;6:22571 pubmed publisher
Haß C, Belz K, Schoeneberger H, Fulda S. Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis. Biochem Pharmacol. 2016;105:14-22 pubmed publisher
Li H, Hu J, Wu S, Wang L, Cao X, Zhang X, et al. Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget. 2016;7:3548-58 pubmed publisher
Manhas R, Gowri V, Madhubala R. Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase. J Biol Chem. 2016;291:1203-20 pubmed publisher
Topkas E, Cai N, Cumming A, Hazar Rethinam M, Gannon O, Burgess M, et al. Auranofin is a potent suppressor of osteosarcoma metastasis. Oncotarget. 2016;7:831-44 pubmed publisher
You B, Park W. Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion. Oncol Rep. 2016;35:546-51 pubmed publisher
Zou P, Chen M, Ji J, Chen W, Chen X, Ying S, et al. Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer. Oncotarget. 2015;6:36505-21 pubmed publisher
Nguyen T, Østergaard J, Gammelgaard B. A method for studies on interactions between a gold-based drug and plasma proteins based on capillary electrophoresis with inductively coupled plasma mass spectrometry detection. Anal Bioanal Chem. 2015;407:8497-503 pubmed publisher
Kaiser M, Maser P, Tadoori L, Ioset J, Brun R. Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning. PLoS ONE. 2015;10:e0135556 pubmed publisher
Tsai L, Xie L, Doré K, Xie L, Del Rio J, King C, et al. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015;290:21845-56 pubmed publisher
Hrabe J, O Leary B, Fath M, Rodman S, Button A, Domann F, et al. Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells. Redox Biol. 2015;5:319-327 pubmed publisher
Sachweh M, Stafford W, Drummond C, McCarthy A, Higgins M, Campbell J, et al. Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. Oncotarget. 2015;6:16488-506 pubmed
Zuverink M, Chen C, Przedpelski A, Blum F, Barbieri J. A Heterologous Reporter Defines the Role of the Tetanus Toxin Interchain Disulfide in Light-Chain Translocation. Infect Immun. 2015;83:2714-24 pubmed publisher
Edwards J, Brown M, Peak E, Bartholomew B, Nash R, Hoffmann K. The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica. PLoS Negl Trop Dis. 2015;9:e0003604 pubmed publisher
Lalli C, Guidi A, Gennari N, Altamura S, Bresciani A, Ruberti G. Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni. PLoS Negl Trop Dis. 2015;9:e0003484 pubmed publisher
Papaioannou M, Mylonas I, Kast R, Brüning A. Disulfiram/copper causes redox-related proteotoxicity and concomitant heat shock response in ovarian cancer cells that is augmented by auranofin-mediated thioredoxin inhibition. Oncoscience. 2014;1:21-9 pubmed
Tian H, Zhang D, Zhang B, Li H, Zhang Q, Li L, et al. Melanoma differentiation associated gene-7/interleukin-24 induces caspase-3 denitrosylation to facilitate the activation of cancer cell apoptosis. J Interferon Cytokine Res. 2015;35:157-67 pubmed publisher
Park N, Chun Y. Auranofin promotes mitochondrial apoptosis by inducing annexin A5 expression and translocation in human prostate cancer cells. J Toxicol Environ Health A. 2014;77:1467-76 pubmed publisher
Vančo J, Gáliková J, Hosek J, Dvorak Z, Paráková L, Trávníček Z. Gold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agents. PLoS ONE. 2014;9:e109901 pubmed publisher
James L, Xu Z, Sluyter R, Hawksworth E, Kelso C, Lai B, et al. An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase. J Inorg Biochem. 2015;142:28-38 pubmed publisher
Park S, Lee J, Berek J, Hu M. Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53. Int J Oncol. 2014;45:1691-8 pubmed publisher
Andrade R, Chaparro J, Capparelli E, Reed S. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. PLoS Negl Trop Dis. 2014;8:e2973 pubmed publisher
Suzuki H, Hatano N, Muraki Y, Itoh Y, Kimura S, Hayashi H, et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014;307:C384-94 pubmed publisher
Chen X, Zhou H, Huang Q, Lu L, Min W. Novel action and mechanism of auranofin in inhibition of vascular endothelial growth factor receptor-3-dependent lymphangiogenesis. Anticancer Agents Med Chem. 2014;14:946-54 pubmed
Sun K, Eriksson S, Tan Y, Zhang L, Arner E, Zhang J. Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury. Biochim Biophys Acta. 2014;1840:2105-11 pubmed publisher
Hosek J, Vančo J, Starha P, Paráková L, Trávníček Z. Effect of 2-chloro-substitution of adenine moiety in mixed-ligand gold(I) triphenylphosphine complexes on anti-inflammatory activity: the discrepancy between the in vivo and in vitro models. PLoS ONE. 2013;8:e82441 pubmed publisher
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Bachnoff N, Cohen Kutner M, Trus M, Atlas D. Intra-membrane signaling between the voltage-gated Ca2+-channel and cysteine residues of syntaxin 1A coordinates synchronous release. Sci Rep. 2013;3:1620 pubmed publisher
Gadadhar S, Karande A. Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway. PLoS ONE. 2013;8:e58304 pubmed publisher
Kim N, Park H, Oh M, Kim I. Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells. BMB Rep. 2013;46:59-64 pubmed
Qu Z, Miao W, Hu S, Li C, Zhuo X, Zong Y, et al. N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity. PLoS ONE. 2012;7:e52788 pubmed publisher
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Pearson S, Scarano W, Stenzel M. Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents. Chem Commun (Camb). 2012;48:4695-7 pubmed publisher
Song L, Li J, Xie S, Qian C, Wang J, Zhang W, et al. Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. PLoS ONE. 2012;7:e31456 pubmed publisher
Ilari A, Baiocco P, Messori L, Fiorillo A, Boffi A, Gramiccia M, et al. A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition. Amino Acids. 2012;42:803-11 pubmed publisher
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product information
Catalog Number :
A6733
Product Name :
Auranofin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA