This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Actinonin
catalog :
A6671
citations: 41
Reference
Im N, Lee D, Kim B, Kim J, Jung K, Kim T, et al. Role of Matrix Metalloproteinases 7 in the Pathogenesis of Laryngopharyngeal Reflux: Decreased E-cadherin in Acid exposed Primary Human Pharyngeal Epithelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Sudevan S, Takiura M, Kubota Y, Higashitani N, Cooke M, Ellwood R, et al. Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans. FASEB J. 2019;33:9540-9550 pubmed publisher
Chepurnova D, Samoilova Е, Verin А, Fesenko A, Anisimov А, Korotaeva A. Inhibition of Meprins Reduces Pulmonary Edema in LPS-Induced Acute Lung Damage. Bull Exp Biol Med. 2019;166:719-721 pubmed publisher
Widya M, Pasutti W, Sachdeva M, Simmons R, Tamrakar P, Krucker T, et al. Development and Optimization of a Higher-Throughput Bacterial Compound Accumulation Assay. ACS Infect Dis. 2019;5:394-405 pubmed publisher
Amberg Johnson K, Yeh E. Host Cell Metabolism Contributes to Delayed-Death Kinetics of Apicoplast Inhibitors in Toxoplasma gondii. Antimicrob Agents Chemother. 2019;63: pubmed publisher
Leipoldt F, Santos Aberturas J, Stegmann D, Wolf F, Kulik A, Lacret R, et al. Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors. Nat Commun. 2017;8:1965 pubmed publisher
Kim B, Lee H, Im N, Lee D, Kang C, Park I, et al. Effect of matrix metalloproteinase inhibitor on disrupted E-cadherin after acid exposure in the human nasal epithelium. Laryngoscope. 2017;: pubmed publisher
Burman J, Pickles S, Wang C, Sekine S, Vargas J, Zhang Z, et al. Mitochondrial fission facilitates the selective mitophagy of protein aggregates. J Cell Biol. 2017;216:3231-3247 pubmed publisher
Quirós P, Prado M, Zamboni N, D Amico D, Williams R, Finley D, et al. Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. J Cell Biol. 2017;216:2027-2045 pubmed publisher
Santiago C, Mudgal G, Reguera J, Recacha R, Albrecht S, Enjuanes L, et al. Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection. Sci Rep. 2017;7:46045 pubmed publisher
Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, et al. Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ? and promotes transendothelial cell migration. FASEB J. 2017;31:1226-1237 pubmed publisher
Richter U, Lahtinen T, Marttinen P, Suomi F, Battersby B. Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness. J Cell Biol. 2015;211:373-89 pubmed publisher
Bienvenut W, Giglione C, Meinnel T. Proteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition. Proteomics. 2015;15:2503-18 pubmed publisher
Minder P, Bayha E, Becker Pauly C, Sterchi E. Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. J Biol Chem. 2012;287:35201-11 pubmed publisher
Bien J, Jefferson T, Causevic M, Jumpertz T, Münter L, Multhaup G, et al. The metalloprotease meprin ? generates amino terminal-truncated amyloid ? peptide species. J Biol Chem. 2012;287:33304-13 pubmed
Pratt J, Roy R, Annabi B. Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. Glycobiology. 2012;22:1245-55 pubmed publisher
Narayanan S, Nampoothiri K. Biochemical characterization of recombinant methionine aminopeptidases (MAPs) from Mycobacterium tuberculosis H37Rv. Mol Cell Biochem. 2012;365:191-202 pubmed publisher
Goemaere E, Melet A, Larue V, Lieutaud A, Alves de Sousa R, Chevalier J, et al. New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity. J Antimicrob Chemother. 2012;67:1392-400 pubmed publisher
Rodrígues Poveda C, Pérez Moreno G, Vidal A, Urbina J, Gonzalez Pacanowska D, Ruiz Perez L. Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi. Mol Biochem Parasitol. 2012;182:83-7 pubmed publisher
Addison M, Minnion J, Shillito J, Suzuki K, Tan T, Field B, et al. A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Endocrinology. 2011;152:4630-40 pubmed publisher
Biton A, Ansorge S, Bank U, Tager M, Reinhold D, Brocke S. Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions. Immunobiology. 2011;216:1295-301 pubmed publisher
Totoritis R, Duraiswami C, Taylor A, Kerrigan J, Campobasso N, Smith K, et al. Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors. Biochemistry. 2011;50:6642-54 pubmed publisher
Fieulaine S, Boularot A, Artaud I, Desmadril M, Dardel F, Meinnel T, et al. Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis. PLoS Biol. 2011;9:e1001066 pubmed publisher
Garcia Caballero A, Ishmael S, Dang Y, Gillie D, Bond J, Milgram S, et al. Activation of the epithelial sodium channel by the metalloprotease meprin β subunit. Channels (Austin). 2011;5:14-22 pubmed
Fernández San Millán A, Obregon P, Veramendi J. Over-expression of peptide deformylase in chloroplasts confers actinonin resistance, but is not a suitable selective marker system for plastid transformation. Transgenic Res. 2011;20:613-24 pubmed publisher
Lee S, Choi K, Lee S, Suh S, Kim B, Lee B. Peptide deformylase inhibitors with retro-amide scaffold: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2010;20:4317-9 pubmed publisher
Wang Z, Herzog C, Kaushal G, Gokden N, Mayeux P. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock. 2011;35:141-7 pubmed publisher
Fichna J, Perlikowska R, Gach K, do Rego J, Cravezic A, Janecka A, et al. The novel endomorphin degradation blockers Tyr-Pro-DClPhe-Phe-NH (EMDB-1) and Tyr-Pro-Ala-NH (EMDB-2) prolong endomorphin-2 action in rat ileum in vitro. Chem Biol Drug Des. 2010;76:77-81 pubmed publisher
Sharma A, Khuller G, Kanwar A, Sharma S. Therapeutic potential of peptide deformylase inhibitors against experimental tuberculosis. J Infect. 2010;60:498-501 pubmed publisher
Mader D, Rabiet M, Boulay F, Peschel A. Formyl peptide receptor-mediated proinflammatory consequences of peptide deformylase inhibition in Staphylococcus aureus. Microbes Infect. 2010;12:415-9 pubmed publisher
Larue V, Seijo B, Tisne C, Dardel F. 1H, 13C and 15N NMR assignments of the E. coli peptide deformylase in complex with a natural inhibitor called actinonin. Biomol NMR Assign. 2009;3:153-5 pubmed publisher
Amero C, Byerly D, McElroy C, Simmons A, Foster M. Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase. Biochemistry. 2009;48:7595-607 pubmed publisher
Sharma A, Sharma S, Khuller G, Kanwar A. In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv. Int J Antimicrob Agents. 2009;34:226-30 pubmed publisher
GAO P, Guo R, Chen J, Chen Y, Wang H, Yu Y, et al. A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice. Atherosclerosis. 2009;207:84-92 pubmed publisher
Nakata H, Ohtsuki T, Sisido M. A protease inhibitor discovery method using fluorescence correlation spectroscopy with position-specific labeled protein substrates. Anal Biochem. 2009;390:121-5 pubmed publisher
Sina A, Lord Dufour S, Annabi B. Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Lett. 2009;279:171-6 pubmed publisher
Berg A, Srivastava D. Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin. Biochemistry. 2009;48:1584-94 pubmed publisher
Duroc Y, Giglione C, Meinnel T. Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis. Antimicrob Agents Chemother. 2009;53:1673-8 pubmed publisher
Herzog C, Haun R, Kaushal V, Mayeux P, Shah S, Kaushal G. Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta. Biochem Biophys Res Commun. 2009;379:904-8 pubmed publisher
Becker Pauly C, Bruns B, Damm O, Schütte A, Hammouti K, Burmester T, et al. News from an ancient world: two novel astacin metalloproteases from the horseshoe crab. J Mol Biol. 2009;385:236-48 pubmed publisher
Kuhlmann U, Chwieralski C, van den Brule S, Rocken C, Reinhold D, Welte T, et al. Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases. Life Sci. 2009;84:1-11 pubmed publisher
product information
Catalog Number :
A6671
Product Name :
Actinonin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA