product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Anti-AKR1C3 antibody, Mouse monoclonal
catalog :
A6229
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
NP6.G6.A6
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
more info or order :
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 4a
Semaan L, Mander N, Cher M, Chinni S. TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model. BMC Cancer. 2019;19:972 pubmed publisher
  • western blot; human; loading ...; fig 1c
Shukla S, Cyrta J, Murphy D, Walczak E, Ran L, Agrawal P, et al. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell. 2017;32:792-806.e7 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:5000; fig 3
Marti N, Galvan J, Pandey A, Trippel M, Tapia C, Muller M, et al. Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome. Mol Cell Endocrinol. 2017;441:116-123 pubmed publisher
Liu C, Yang J, Armstrong C, Lou W, Liu L, Qiu X, et al. AKR1C3 promotes AR-V7 protein stabilization and confers resistance to AR-targeted therapies in advanced prostate cancer. Mol Cancer Ther. 2019;: pubmed publisher
Loiselle J, Knee J, Sutherland L. Human lung epithelial cells cultured in the presence of radon-emitting rock experience gene expression changes similar to those associated with tobacco smoke exposure. J Environ Radioact. 2019;196:64-81 pubmed publisher
Kawaguchi Y, Mizuno H, Horikawa M, Kano M, Yamada K, Yamakawa F, et al. Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma. Tohoku J Exp Med. 2017;241:125-129 pubmed publisher
Liu C, Armstrong C, Lou W, Lombard A, Evans C, Gao A. Inhibition of AKR1C3 Activation Overcomes Resistance to Abiraterone in Advanced Prostate Cancer. Mol Cancer Ther. 2017;16:35-44 pubmed publisher
Abbattista M, Jamieson S, Gu Y, Nickel J, Pullen S, Patterson A, et al. Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma. Cancer Biol Ther. 2015;16:610-22 pubmed publisher
Liu C, Lou W, Zhu Y, Yang J, Nadiminty N, Gaikwad N, et al. Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer. Cancer Res. 2015;75:1413-22 pubmed publisher
Mine N, Yamamoto S, Kufe D, Von Hoff D, Kawabe T. Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP501 in vitro. Mol Cancer Ther. 2014;13:2215-25 pubmed publisher
Huebbers C, Preuss S, Kolligs J, Vent J, Stenner M, Wieland U, et al. Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis. PLoS ONE. 2013;8:e57207 pubmed publisher
Catalano R, Wilson M, Boddy S, Jabbour H. Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle. Mol Hum Reprod. 2011;17:182-92 pubmed publisher
Breuiller Fouche M, Leroy M, Dubois O, Reinaud P, Chissey A, Qi H, et al. Differential expression of the enzymatic system controlling synthesis, metabolism, and transport of PGF2 alpha in human fetal membranes. Biol Reprod. 2010;83:155-62 pubmed publisher
Lin H, Steckelbroeck S, Fung K, Jones A, Penning T. Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate. Steroids. 2004;69:795-801 pubmed
product information
Catalog Number :
A6229
Product Name :
Anti-AKR1C3 antibody, Mouse monoclonal
Product Type :
ANTIBODIES - SIAL
Product Group :
Protein & Pathway Technologies
Clonality :
monoclonal
Conjugation :
unconjugated
Clone Name :
NP6.G6.A6
Isotype :
IgG1
Product Description :
clone NP6.G6.A6, purified from hybridoma cell culture
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA