This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Calpain Inhibitor I
catalog :
A6185
citations: 79
Reference
Ando K, Ndjim M, Turbant S, Fontaine G, Pregoni G, Dauphinot L, et al. The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer's disease. Acta Neuropathol Commun. 2020;8:79 pubmed publisher
Salvage S, Gallant E, Beard N, Ahmad S, Valli H, Fraser J, et al. Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse. J Cell Sci. 2019;132: pubmed publisher
Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, et al. Infection with flaviviruses requires BCLXL for cell survival. PLoS Pathog. 2018;14:e1007299 pubmed publisher
Wan L, Ren L, Chen L, Wang G, Liu X, Wang B, et al. M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. Front Mol Neurosci. 2018;11:287 pubmed publisher
Kim H, Zamel R, Bai X, Lu C, Keshavjee S, Keshavjee S, et al. Ischemia-reperfusion induces death receptor-independent necroptosis via calpain-STAT3 activation in a lung transplant setting. Am J Physiol Lung Cell Mol Physiol. 2018;315:L595-L608 pubmed publisher
Scott I, Majithiya J, Sandén C, Thornton P, Sanders P, Moore T, et al. Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. Sci Rep. 2018;8:3363 pubmed publisher
Gallagher C, Garri C, Cain E, Ang K, Wilson C, Chen S, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. elife. 2016;5: pubmed publisher
Harwell C, Coleman M. Synaptophysin depletion and intraneuronal A? in organotypic hippocampal slice cultures from huAPP transgenic mice. Mol Neurodegener. 2016;11:44 pubmed publisher
Geng F, Cheng X, Wu X, Yoo J, Cheng C, Guo J, et al. Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis. Clin Cancer Res. 2016;22:5337-5348 pubmed
Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, et al. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Nat Commun. 2016;7:11379 pubmed publisher
Cheon Y, Baek J, Park S, Ahn S, Lee M, Oh J, et al. Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1 expression. BMC Complement Altern Med. 2015;15:280 pubmed publisher
Kherrouche Z, Monte D, Werkmeister E, Stoven L, De Launoit Y, Cortot A, et al. PEA3 transcription factors are downstream effectors of Met signaling involved in migration and invasiveness of Met-addicted tumor cells. Mol Oncol. 2015;9:1852-67 pubmed publisher
Lee M, Jeong M, Lee H, Han H, Ko A, Hewitt S, et al. PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis. Nat Commun. 2015;6:7769 pubmed publisher
Hashimoto Y, Inagaki H, Hoshino S. Calpain mediates processing of the translation termination factor eRF3 into the IAP-binding isoform p-eRF3. FEBS Lett. 2015;589:2241-7 pubmed publisher
Zhang C, Jiang Y, Zhang J, Huang J, Wang J. 8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells. Int J Mol Sci. 2015;16:14979-96 pubmed publisher
Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, et al. Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS ONE. 2015;10:e0131008 pubmed publisher
Valera M, de Armas Rillo L, Barroso González J, Ziglio S, Batisse J, Dubois N, et al. The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation. Retrovirology. 2015;12:53 pubmed publisher
Takashima K, Saitoh A, Funabashi T, Hirose S, Yagi C, Nozaki S, et al. COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions. J Cell Sci. 2015;128:2805-15 pubmed publisher
Montagne R, Berbon M, Doublet L, Debreuck N, Baranzelli A, Drobecq H, et al. Necrosis- and apoptosis-related Met cleavages have divergent functional consequences. Cell Death Dis. 2015;6:e1769 pubmed publisher
Zhao K, Murray E, Murray S. Fibroblastic synoviocytes secrete plasma proteins via α2 -macroglobulins serving as intracellular and extracellular chaperones. J Cell Biochem. 2015;116:2563-76 pubmed publisher
Cho J, Lee S, Oh A, Yoon M, Woo T, Park B. NF2 blocks Snail-mediated p53 suppression in mesothelioma. Oncotarget. 2015;6:10073-85 pubmed
Herrmann L, Wiegmann C, Arsalan Werner A, Hilbrich I, Jäger C, Flach K, et al. Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PLoS ONE. 2015;10:e0119423 pubmed publisher
Vibulyaseck S, Luo Y, Fujita H, Oh Nishi A, Ohki Hamazaki H, Sugihara I. Compartmentalization of the chick cerebellar cortex based on the link between the striped expression pattern of aldolase C and the topographic olivocerebellar projection. J Comp Neurol. 2015;523:1886-912 pubmed publisher
Rothmeier A, Marchese P, Petrich B, Furlan Freguia C, Ginsberg M, Ruggeri Z, et al. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. J Clin Invest. 2015;125:1471-84 pubmed publisher
Jin H, Mimura N, Kashio M, Koseki H, Aoe T. Late-onset of spinal neurodegeneration in knock-in mice expressing a mutant BiP. PLoS ONE. 2014;9:e112837 pubmed publisher
Waheed A, Kuruppu N, Felton K, D Souza D, Freed E. In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity. PLoS ONE. 2014;9:e111628 pubmed publisher
Yoon S, Park S, Han J, Kang J, Kim J, Lee J, et al. Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns. Cell Death Dis. 2014;5:e1494 pubmed publisher
Chen G, Wang T, Uttarwar L, vanKrieken R, Li R, Chen X, et al. SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells. J Mol Cell Biol. 2014;6:516-30 pubmed publisher
Mázala D, Grange R, Chin E. The role of proteases in excitation-contraction coupling failure in muscular dystrophy. Am J Physiol Cell Physiol. 2015;308:C33-40 pubmed publisher
Esumi M, Ishibashi M, Yamaguchi H, Nakajima S, Tai Y, Kikuta S, et al. Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection. Hepatology. 2015;61:437-46 pubmed publisher
Zhang Y, Calado R, Rao M, Hong J, Meeker A, Dumitriu B, et al. Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas. PLoS ONE. 2014;9:e101010 pubmed publisher
Schaller Schönitz M, Barzan D, Williamson A, Griffiths J, Dallmann I, Battmer K, et al. BCR-ABL affects STAT5A and STAT5B differentially. PLoS ONE. 2014;9:e97243 pubmed publisher
Phillips Mason P, Craig S, Brady Kalnay S. A protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cells. J Cell Biochem. 2014;115:1609-23 pubmed publisher
Son S, Byun J, Roh S, Kim S, Mook Jung I. Reduced IRE1? mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor. Cell Death Dis. 2014;5:e1188 pubmed publisher
Pollock C, McDonough S, Wang V, Lee H, Ringer L, Li X, et al. Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells. Oncotarget. 2014;5:1683-98 pubmed
Noda K, Akita H, Ogata M, Saji M. Paclitaxel-induced hyperalgesia modulates negative affective component of pain and NR1 receptor expression in the frontal cortex in rats. Neurosci Res. 2014;80:32-7 pubmed publisher
Duregotti E, Tedesco E, Montecucco C, Rigoni M. Calpains participate in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins. Toxicon. 2013;64:20-8 pubmed publisher
Zheng L, Saunders C, Sorensen E, Waxmonsky N, Conner S. Notch signaling from the endosome requires a conserved dileucine motif. Mol Biol Cell. 2013;24:297-307 pubmed publisher
Lynch C, Lazar A, Iskratsch T, Zhang X, Sheetz M. Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions. Mol Biol Cell. 2013;24:21-30 pubmed publisher
Sebe J, Bershteyn M, Hirotsune S, Wynshaw Boris A, Baraban S. ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. J Neurophysiol. 2013;109:429-36 pubmed publisher
Velma V, Broome H, Hebert M. Regulated specific proteolysis of the Cajal body marker protein coilin. Chromosoma. 2012;121:629-42 pubmed publisher
Przystal J, Umukoro E, Stoneham C, Yata T, O Neill K, Syed N, et al. Proteasome inhibition in cancer is associated with enhanced tumor targeting by the adeno-associated virus/phage. Mol Oncol. 2013;7:55-66 pubmed publisher
Ali M, Stepanko A, Fan X, Holt A, Schulz R. Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity. Biochem Biophys Res Commun. 2012;423:1-5 pubmed publisher
Mallik S, Li D, Cui M, Song H, Park H, Kim H. Synthesis and evaluation of peptidyl α,β-unsaturated carbonyl derivatives as anti-malarial calpain inhibitors. Arch Pharm Res. 2012;35:469-79 pubmed publisher
Shell J, Lawrence D. Proteolytic regulation of the mitochondrial cAMP-dependent protein kinase. Biochemistry. 2012;51:2258-64 pubmed publisher
Chang P, Chen Y, Long D, Qin W, Mou X. Degradation of mouse NTE-related esterase by macroautophagy and the proteasome. Mol Biol Rep. 2012;39:7125-31 pubmed publisher
Kim S, Kim M, Ann E, Mo J, Yoon J, Park H. Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase. J Cell Sci. 2012;125:1296-308 pubmed publisher
Liu D, Yan Z, Minshall R, Schwartz D, Chen Y, Hu G. Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2012;302:L370-9 pubmed publisher
Zhou W, Hu J, Tang H, Wang D, Huang X, He C, et al. Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors. BMC Cancer. 2011;11:485 pubmed publisher
Fujita H, Kato T, Watanabe N, Takahashi T, Kitagawa S. Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation. Arch Biochem Biophys. 2011;516:121-7 pubmed publisher
Lee Y, Seol J, Jeong J, Moon M, Park S. Inhibition of the ubiquitin-proteasome system sensitizes TRAIL-resistant prostate cancer cells by up-regulation of death receptor 5. Mol Med Rep. 2011;4:1255-9 pubmed publisher
Keembiyehetty C, Krzeslak A, Love D, Hanover J. A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome. J Cell Sci. 2011;124:2851-60 pubmed publisher
Moon B, Kim H, Kim M, Yang D, Lee J, Cho K, et al. Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling. Stem Cells. 2011;29:320-31 pubmed publisher
Shah D, Kwon S, Bale S, Banerjee A, Dordick J, Kane R. Regulation of stem cell signaling by nanoparticle-mediated intracellular protein delivery. Biomaterials. 2011;32:3210-9 pubmed publisher
Latonen L, Moore H, Bai B, Jäämaa S, Laiho M. Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability. Oncogene. 2011;30:790-805 pubmed publisher
Pérot G, Chibon F, Montero A, Lagarde P, De The H, Terrier P, et al. Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics. Am J Pathol. 2010;177:2080-90 pubmed publisher
Bastián Y, Roa Espitia A, Mújica A, Hernández González E. Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton. Reproduction. 2010;140:673-84 pubmed publisher
Srivastava N, Cefalu A, Noto D, Schonfeld G, Averna M, Srivastava R. The production of 85 kDa N-terminal fragment of apolipoprotein B in mutant HepG2 cells generated by targeted modification of apoB gene occurs by ALLN-inhibitable protease cleavage during translocation. Biochem Biophys Res Commun. 2010;398:665-70 pubmed publisher
Gilchrist J, Cook T, Abrenica B, Rashidkhani B, Pierce G. Extensive autolytic fragmentation of membranous versus cytosolic calpain following myocardial ischemia-reperfusion. Can J Physiol Pharmacol. 2010;88:584-94 pubmed publisher
Mizukoshi S, Nakazawa M, Sato K, Ozaki T, Metoki T, Ishiguro S. Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration. Exp Eye Res. 2010;91:353-61 pubmed publisher
Perez De La Cruz V, Elinos Calderón D, Carrillo Mora P, Silva Adaya D, Konigsberg M, Moran J, et al. Time-course correlation of early toxic events in three models of striatal damage: modulation by proteases inhibition. Neurochem Int. 2010;56:834-42 pubmed publisher
Vlashi E, Pajonk F. Targeted cancer stem cell therapies start with proper identification of the target. Mol Cancer Res. 2010;8:291; author reply 291 pubmed publisher
Nobukuni M, Mochizuki H, Okada S, Kameyama N, Tanaka A, Yamamoto H, et al. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. J Pharmacol Sci. 2009;111:392-404 pubmed
Seol J, Lee H, Lee Y, Lee Y, Kang H, Kim I, et al. Hypoxic resistance to articular chondrocyte apoptosis--a possible mechanism of maintaining homeostasis of normal articular cartilage. FEBS J. 2009;276:7375-85 pubmed publisher
Eder C, Frankenberger M, Stanzel F, Seidel A, Schramm K, Ziegler Heitbrock L, et al. Ultrafine carbon particles down-regulate CYP1B1 expression in human monocytes. Part Fibre Toxicol. 2009;6:27 pubmed publisher
Moura P, Dame J, Fidock D. Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 2009;53:4968-78 pubmed publisher
Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, et al. Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly. Nat Med. 2009;15:1202-7 pubmed publisher
Jung S, Zheng B, Choi Y, Soh B, Kim S, Park K, et al. Antimalarial effect of N-acetyl-L-Leucyl-L-leucyl-L-norleucinal by the inhibition of Plasmodium falciparum Calpain. Arch Pharm Res. 2009;32:899-906 pubmed publisher
Santos Rosa H, Kirmizis A, Nelson C, Bartke T, Saksouk N, Cote J, et al. Histone H3 tail clipping regulates gene expression. Nat Struct Mol Biol. 2009;16:17-22 pubmed publisher
Donkor I, Korukonda R. Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position. Bioorg Med Chem Lett. 2008;18:4806-8 pubmed publisher
Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A. 2007;104:19023-8 pubmed
MacDonald M, Lamerdin J, Owens S, Keon B, Bilter G, Shang Z, et al. Identifying off-target effects and hidden phenotypes of drugs in human cells. Nat Chem Biol. 2006;2:329-37 pubmed
Aubin S, Martin B, Delcros J, Arlot Bonnemains Y, Baudy Floc h M. Retro hydrazino-azapeptoids as peptidomimetics of proteasome inhibitors. J Med Chem. 2005;48:330-4 pubmed
Hoffman L, Rechsteiner M. Nucleotidase activities of the 26 S proteasome and its regulatory complex. J Biol Chem. 1996;271:32538-45 pubmed
Lu Q, Mellgren R. Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells. Arch Biochem Biophys. 1996;334:175-81 pubmed
Griscavage J, Wilk S, Ignarro L. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 1996;93:3308-12 pubmed
Sherwood S, Kung A, Roitelman J, Simoni R, Schimke R. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc Natl Acad Sci U S A. 1993;90:3353-7 pubmed
Squier M, Miller A, Malkinson A, Cohen J. Calpain activation in apoptosis. J Cell Physiol. 1994;159:229-37 pubmed
Sasaki T, Kishi M, Saito M, Tanaka T, Higuchi N, Kominami E, et al. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J Enzyme Inhib. 1990;3:195-201 pubmed
product information
Catalog Number :
A6185
Product Name :
Calpain Inhibitor I
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥97% (TLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA