Kasteel E, Nijmeijer S, Darney K, Lautz L, Dorne J, Kramer N, et al. Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics. Arch Toxicol. 2020;94:4055-4065 pubmed publisher

Betapudi V, Goswami R, Silayeva L, Doctor D, Chilukuri N. Gene therapy delivering a paraoxonase 1 variant offers long-term prophylactic protection against nerve agents in mice. Sci Transl Med. 2020;12: pubmed publisher

Zhou Y, Lu X, Yang H, Chen Y, Wang F, Li J, et al. Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations. Molecules. 2019;24: pubmed publisher

Lobentanzer S, Hanin G, Klein J, Soreq H. Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder. Cell Rep. 2019;29:764-777.e5 pubmed publisher

Pérez González R, Sahoo S, Gauthier S, Kim Y, Li M, Kumar A, et al. Neuroprotection mediated by cystatin C-loaded extracellular vesicles. Sci Rep. 2019;9:11104 pubmed publisher

Unsal Tan O, Tuylu Kucukkilinc T, Ayazgok B, Balkan A, Ozadali Sari K. Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease. Medchemcomm. 2019;10:1018-1026 pubmed publisher

Thakkar J, Gupta S, Prabha C. Acetylcholine esterase enzyme doped multiwalled carbon nanotubes for the detection of organophosphorus pesticide using cyclic voltammetry. Int J Biol Macromol. 2019;137:895-903 pubmed publisher

Zhu A, Lao C, Wang Z, Chen Y, Bai C. Characterization of Crocetin-Monoglucuronide as a Neuron-Protective Metabolite of Crocin-1. Mol Nutr Food Res. 2019;:e1900024 pubmed publisher

Dos Santos P, Francisco C, Coqueiro A, Leimann F, Pinela J, Calhelha R, et al. The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities. Food Funct. 2019;10:573-582 pubmed publisher

Boga M, Ertaş A, Yılmaz M, Kizil M, Ceken B, Haşimi N, et al. UHPLC-ESI-MS/MS and GC-MS Analyses on Phenolic, Fatty Acid and Essential Oil of Verbascum pinetorum with Antioxidant, Anticholinesterase, Antimicrobial and DNA Damage Protection Effects. Iran J Pharm Res. 2016;15:393-405 pubmed

Raksat A, Sripisut T, Maneerat W. Bioactive Xanthones from Cratoxylum cochinchinense. Nat Prod Commun. 2015;10:1969-72 pubmed

Moniruzzaman M, Asaduzzaman M, Hossain M, Sarker J, Rahman S, Rashid M, et al. In vitro antioxidant and cholinesterase inhibitory activities of methanolic fruit extract of Phyllanthus acidus. BMC Complement Altern Med. 2015;15:403 pubmed publisher

Chen P, Lin G, Chang H, Sun D. Megakaryocytic differentiation of mouse embryonic stem cells via coculture with immortalized OP9 stromal cells. Exp Cell Res. 2015;339:44-50 pubmed publisher

Salleh W, Ahmad F, Yen K. Antioxidant and Anticholinesterase Activities of Essential Oils of Cinnamomum griffithii and C. macrocarpum. Nat Prod Commun. 2015;10:1465-8 pubmed

Lomarat P, Chancharunee S, Anantachoke N, Kitphati W, Sripha K, Bunyapraphatsara N. Bioactivity-guided Separation of the Active Compounds in Acacia pennata Responsible for the Prevention of Alzheimer's Disease. Nat Prod Commun. 2015;10:1431-4 pubmed

Semenov V, Zueva I, Mukhamedyarov M, Lushchekina S, Kharlamova A, Petukhova E, et al. 6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. ChemMedChem. 2015;10:1863-74 pubmed publisher

Salleh W, Ahmada F, Yen K, Zulkifli R. Chemical Compositions and Biological Activities of Essential Oils of Beilschmiedia glabra. Nat Prod Commun. 2015;10:1297-300 pubmed

Haverroth G, Welang C, Mocelin R, Postay D, Bertoncello K, Franscescon F, et al. Copper acutely impairs behavioral function and muscle acetylcholinesterase activity in zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2015;122:440-7 pubmed publisher

Akintunde J, Oboh G. Subchronic exposure to leachate activates key markers linked with neurological disorder in Wistar male rat. Environ Sci Pollut Res Int. 2015;22:18541-53 pubmed publisher

Kumar S. Dual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin. Indian J Pharmacol. 2015;47:444-6 pubmed publisher

Krishna G, Divyashri G, Prapulla S, Muralidhara -. A Combination Supplement of Fructo- and Xylo-Oligosaccharides Significantly Abrogates Oxidative Impairments and Neurotoxicity in Maternal/Fetal Milieu Following Gestational Exposure to Acrylamide in Rat. Neurochem Res. 2015;40:1904-18 pubmed publisher

Bajda M, Jończyk J, Malawska B, Czarnecka K, Girek M, Olszewska P, et al. Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Bioorg Med Chem. 2015;23:5610-8 pubmed publisher

Arab S, Sadat Ebrahimi S, Mohammadi Khanaposhtani M, Moradi A, Nadri H, Mahdavi M, et al. Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives as New Acetylcholinesterase Inhibitors. Arch Pharm (Weinheim). 2015;348:643-9 pubmed publisher

Xiao D, Yang T, Desneux N, Han P, Gao X. Assessment of Sublethal and Transgenerational Effects of Pirimicarb on the Wheat Aphids Rhopalosiphum padi and Sitobion avenae. PLoS ONE. 2015;10:e0128936 pubmed publisher

Uddin M, Afrin R, Uddin M, Uddin M, Alam A, Rahman A, et al. Vanda roxburghii chloroform extract as a potential source of polyphenols with antioxidant and cholinesterase inhibitory activities: identification of a strong phenolic antioxidant. BMC Complement Altern Med. 2015;15:195 pubmed publisher

Valiveti A, Bhalerao U, Acharya J, Karade H, Gundapu R, Halve A, et al. Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE). Chem Biol Interact. 2015;237:125-32 pubmed publisher

Pereira H, Custódio L, Rodrigues M, de Sousa C, Oliveira M, Barreira L, et al. Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Mar Drugs. 2015;13:3531-49 pubmed publisher

Bagheri S, Khoobi M, Nadri H, Moradi A, Emami S, Jalili Baleh L, et al. Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety. Chem Biol Drug Des. 2015;86:1215-20 pubmed publisher

Qi H, Li H, Ma P, You J. Integrated sediment quality assessment through biomarker responses and bioavailability measurements: Application in Tai Lake, China. Ecotoxicol Environ Saf. 2015;119:148-54 pubmed publisher

Chen L, Xu W, Shao R, Du X. Bioactivities of phytochemicals in Araiostegia yunnanensis (Christ). Food Chem. 2015;186:37-45 pubmed publisher

Sang Z, Qiang X, Li Y, Wu B, Zhang H, Zhao M, et al. Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Chem Biol Drug Des. 2015;86:1168-77 pubmed publisher

Al Aboudi A, Al Qawasmeh R, Shahwan A, Mahmood U, Khalid A, Ul Haq Z. In-silico identification of the binding mode of synthesized adamantyl derivatives inside cholinesterase enzymes. Acta Pharmacol Sin. 2015;36:879-86 pubmed publisher

Murata T, Selenge E, Oikawa S, Ageishi K, Batkhuu J, Sasaki K, et al. Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica. J Nat Med. 2015;69:471-8 pubmed publisher

Kovarik Z, Maček Hrvat N, Katalinić M, Sit R, Paradyse A, Zunec S, et al. Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes. Chem Res Toxicol. 2015;28:1036-44 pubmed publisher

Manjunath M, Muralidhara -. Standardized extract of Withania somnifera (Ashwagandha) markedly offsets rotenone-induced locomotor deficits, oxidative impairments and neurotoxicity in Drosophila melanogaster. J Food Sci Technol. 2015;52:1971-81 pubmed publisher

Akrami H, Mirjalili B, Khoobi M, Moradi A, Nadri H, Emami S, et al. 9H-Carbazole Derivatives Containing the N-Benzyl-1,2,3-triazole Moiety as New Acetylcholinesterase Inhibitors. Arch Pharm (Weinheim). 2015;348:366-74 pubmed publisher

Krishna G, Muralidhara -. Inulin supplementation during gestation mitigates acrylamide-induced maternal and fetal brain oxidative dysfunctions and neurotoxicity in rats. Neurotoxicol Teratol. 2015;49:49-58 pubmed publisher

Zhu J, Huan C, Si G, Yang H, Yin L, Ren Q, et al. The acetylcholinesterase (AChE) inhibition analysis of medaka (Oryzias latipes) in the exposure of three insecticides. Pak J Pharm Sci. 2015;28:671-4 pubmed

Liew K, Chan K, Lee C. Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties. Eur J Med Chem. 2015;94:195-210 pubmed publisher

Blohberger J, Kunz L, Einwang D, Berg U, Berg D, Ojeda S, et al. Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?. Cell Death Dis. 2015;6:e1685 pubmed publisher

Radulović N, Mladenović M, Randjelović P, Stojanović N, Dekić M, Blagojević P. Toxic essential oils. Part IV: The essential oil of Achillea falcata L. as a source of biologically/pharmacologically active trans-sabinyl esters. Food Chem Toxicol. 2015;80:114-129 pubmed publisher

Koca M, Yerdelen K, Anil B, Kasap Z. Microwave-assisted synthesis, molecular docking, and cholinesterase inhibitory activities of new ethanediamide and 2-butenediamide analogues. Chem Pharm Bull (Tokyo). 2015;63:210-7 pubmed publisher

Tel G, Ozturk M, Duru M, Türkoglu A. Antioxidant and anticholinesterase activities of five wild mushroom species with total bioactive contents. Pharm Biol. 2015;53:824-30 pubmed publisher

Park D, Jeon H, Park E, Bae I, Kim Y, Lee S. Highly selective biomarkers for pesticides developed in Eisenia fetida using SELDI-TOF MS. Environ Toxicol Pharmacol. 2015;39:635-42 pubmed publisher

Liendro N, Ferrari A, Mardirosian M, Lascano C, Venturino A. Toxicity of the insecticide chlorpyrifos to the South American toad Rhinella arenarum at larval developmental stage. Environ Toxicol Pharmacol. 2015;39:525-35 pubmed publisher

Sola I, Castellà S, Viayna E, Galdeano C, Taylor M, Gbedema S, et al. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorg Med Chem. 2015;23:5156-67 pubmed publisher

Cao Y, Cai J, Zhang S, Yuan N, Li X, Fang Y, et al. Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice. Exp Hematol. 2015;43:488-94 pubmed publisher

Zhang S, Ma Q, Huang S, Dai H, Guo Z, Yu Z, et al. Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes. Phytochemistry. 2015;110:133-9 pubmed publisher

Du C, Min A, Kim H, Shin S, Yu H, Sohn E, et al. Deer bone extract prevents against scopolamine-induced memory impairment in mice. J Med Food. 2015;18:157-65 pubmed publisher

Cortes N, Posada Duque R, Alvarez R, Alzate F, Berkov S, Cardona Gómez G, et al. Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: a comparative study. Life Sci. 2015;122:42-50 pubmed publisher

Scheffel C, Thiermann H, Worek F. Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. Toxicol Lett. 2015;232:557-65 pubmed publisher

Singh J, Kakalij R, Kshirsagar R, Kumar B, Komakula S, Diwan P. Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice. Pharm Biol. 2015;53:630-6 pubmed publisher

Palit P, Mukherjee D, Mandal S. Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model. J Ethnopharmacol. 2015;159:274-84 pubmed publisher

Reiter G, Muller S, Hill I, Weatherby K, Thiermann H, Worek F, et al. In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects. Toxicol Lett. 2015;232:438-48 pubmed publisher

Yerdelen K, Koca M, Kasap Z, Anil B. Preparation, anticholinesterase activity, and docking study of new 2-butenediamide and oxalamide derivatives. J Enzyme Inhib Med Chem. 2015;30:671-8 pubmed publisher

Choi J, Haulader S, Karki S, Jung H, Kim H, Jung H. Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis. Arch Pharm Res. 2015;38:1477-87 pubmed publisher

Thomsen R, Nielsen L, Holm N, Rasmussen H, Linnet K. Synthetic cannabimimetic agents metabolized by carboxylesterases. Drug Test Anal. 2015;7:565-76 pubmed publisher

Ertaş A, Boga M, Kizil M, Ceken B, Gören A, Haşimi N, et al. Chemical profile and biological activities of Veronica thymoides subsp. pseudocinerea. Pharm Biol. 2015;53:334-9 pubmed publisher

Cortes N, Alvarez R, Osorio E, Alzate F, Berkov S, Osorio E. Alkaloid metabolite profiles by GC/MS and acetylcholinesterase inhibitory activities with binding-mode predictions of five Amaryllidaceae plants. J Pharm Biomed Anal. 2015;102:222-8 pubmed publisher

Jung H, Karki S, Kim J, Choi J. BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos. Arch Pharm Res. 2015;38:1178-87 pubmed publisher

Worek F, Elsinghorst P, Koller M, Thiermann H. Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. Toxicol Lett. 2014;231:92-8 pubmed publisher

Zhu Y, Li X, Yu H, Xiong Y, Zhang P, Pi H, et al. Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities. Arch Pharm Res. 2015;38:604-13 pubmed publisher

Bianco K, Otero S, Oliver A, Nahabedian D, Kristoff G. Resistance in cholinesterase activity after an acute and subchronic exposure to azinphos-methyl in the freshwater gastropod Biomphalaria straminea. Ecotoxicol Environ Saf. 2014;109:85-92 pubmed publisher

Khaw K, Choi S, Tan S, Wahab H, Chan K, Murugaiyah V. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine. 2014;21:1303-9 pubmed publisher

Pérez Areales F, Di Pietro O, Espargaró A, Vallverdú Queralt A, Galdeano C, Ragusa I, et al. Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties. Bioorg Med Chem. 2014;22:5298-307 pubmed publisher

Bajaj P, Aggarwal G, Tripathy R, Pande A. Interplay between amino acid residues at positions 192 and 115 in modulating hydrolytic activities of human paraoxonase 1. Biochimie. 2014;105:202-10 pubmed publisher

Swale D, Sun B, Tong F, Bloomquist J. Neurotoxicity and mode of action of N, N-diethyl-meta-toluamide (DEET). PLoS ONE. 2014;9:e103713 pubmed publisher

Salleh W, Ahmad F, Yen K. Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae). Arch Pharm Res. 2015;38:485-93 pubmed publisher

Cole T, Li W, Co A, Hay A, MacDonald J, Bammler T, et al. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci. 2014;141:409-22 pubmed publisher

Li W, Cai C, Dong W, Guo Z, Wang H, Mei W, et al. 2-(2-phenylethyl)chromone derivatives from Chinese agarwood induced by artificial holing. Fitoterapia. 2014;98:117-23 pubmed publisher

Abdalla F, Cardoso A, Schmatz R, Gonçalves J, Baldissarelli J, Martins C, et al. Protective effect of quercetin in ecto-enzymes, cholinesterases, and myeloperoxidase activities in the lymphocytes of rats exposed to cadmium. Mol Cell Biochem. 2014;396:201-11 pubmed publisher

Alza N, Richmond V, Baier C, Freire E, Baggio R, Murray A. Synthesis and cholinesterase inhibition of cativic acid derivatives. Bioorg Med Chem. 2014;22:3838-49 pubmed publisher

Uriostegui Acosta M, Hernandez Ochoa I, Sánchez Gutiérrez M, Piña Guzmán B, Rafael Vázquez L, Solís Heredia M, et al. Methamidophos alters sperm function and DNA at different stages of spermatogenesis in mice. Toxicol Appl Pharmacol. 2014;279:391-400 pubmed publisher

Choi J, Islam M, Ali M, Kim Y, Park H, Sohn H, et al. The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities. Arch Pharm Res. 2014;37:1354-63 pubmed publisher

Mathew M, Subramanian S. In vitro evaluation of anti-Alzheimer effects of dry ginger (Zingiber officinale Roscoe) extract. Indian J Exp Biol. 2014;52:606-12 pubmed

Alipour M, Khoobi M, Moradi A, Nadri H, Homayouni Moghadam F, Emami S, et al. Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives. Eur J Med Chem. 2014;82:536-44 pubmed publisher

Dingova D, Leroy J, Check A, Garaj V, Krejci E, Hrabovska A. Optimal detection of cholinesterase activity in biological samples: modifications to the standard Ellman's assay. Anal Biochem. 2014;462:67-75 pubmed publisher

Ferchmin P, Andino M, Reyes Salaman R, Alves J, Velez Roman J, Cuadrado B, et al. 4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration. Neurotoxicology. 2014;44:80-90 pubmed publisher

Tan W, Khairuddean M, Wong K, Khaw K, Vikneswaran M. New cholinesterase inhibitors from Garcinia atroviridis. Fitoterapia. 2014;97:261-7 pubmed publisher

Schwarz S, Lucas S, Sommerwerk S, Csuk R. Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases. Bioorg Med Chem. 2014;22:3370-8 pubmed publisher

Shi Z, Song D, Li R, Yang H, Qi L, Xin G, et al. Identification of effective combinatorial markers for quality standardization of herbal medicines. J Chromatogr A. 2014;1345:78-85 pubmed publisher

Kwiatkowska M, Nowacka Krukowska H, Bukowska B. The effect of glyphosate, its metabolites and impurities on erythrocyte acetylcholinesterase activity. Environ Toxicol Pharmacol. 2014;37:1101-8 pubmed publisher

Zhuang X, Wei X, Tan Y, Xiao W, Yang H, Xie J, et al. Contribution of carboxylesterase and cytochrome P450 to the bioactivation and detoxification of isocarbophos and its enantiomers in human liver microsomes. Toxicol Sci. 2014;140:40-8 pubmed publisher

Khan D, Khan H, Khan F, Khan S, Badshah S, Khan A, et al. New cholinesterase inhibitory constituents from Lonicera quinquelocularis. PLoS ONE. 2014;9:e94952 pubmed publisher

Jamila N, Khairuddean M, Yeong K, Osman H, Murugaiyah V. Cholinesterase inhibitory triterpenoids from the bark of Garcinia hombroniana. J Enzyme Inhib Med Chem. 2015;30:133-9 pubmed publisher

Güngördü A, Uckun M. Comparative assessment of in vitro and in vivo toxicity of azinphos methyl and its commercial formulation. Environ Toxicol. 2015;30:1091-101 pubmed publisher

Friggeri L, De Vita D, Pandolfi F, Tortorella S, Costi R, Di Santo R, et al. Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors. J Enzyme Inhib Med Chem. 2015;30:166-72 pubmed publisher

Kubínová R, Pořízková R, Navrátilová A, Farsa O, Hanáková Z, Bačinská A, et al. Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth. J Enzyme Inhib Med Chem. 2014;29:749-52 pubmed publisher

Anand T, Pandareesh M, Bhat P, Venkataramana M. Anti-apoptotic mechanism of Bacoside rich extract against reactive nitrogen species induced activation of iNOS/Bax/caspase 3 mediated apoptosis in L132 cell line. Cytotechnology. 2014;66:823-38 pubmed publisher

Isik I, Celik I. Investigation of neurotoxic and immunotoxic effects of some plant growth regulators at subacute and subchronic applications on rats. Toxicol Ind Health. 2015;31:1095-105 pubmed publisher

Moreira S, Moreira Santos M, Rendón von Osten J, da Silva E, Ribeiro R, Guilhermino L, et al. Ecotoxicological tools for the tropics: Sublethal assays with fish to evaluate edge-of-field pesticide runoff toxicity. Ecotoxicol Environ Saf. 2010;73:893-9 pubmed publisher

Malicdan M, Noguchi S, Nishino I. Monitoring autophagy in muscle diseases. Methods Enzymol. 2009;453:379-96 pubmed publisher

Banerjee B, Ganguly D. Thermodynamic studies with acetylthiocholine on nicotinic receptors of mammalian skeletal muscle in vitro. Biochem Pharmacol. 1995;49:1713-6 pubmed

Froede H, Wilson I. Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine. J Biol Chem. 1984;259:11010-3 pubmed

Puu G, Koch M. Comparison of kinetic parameters for acetylthiocholine, soman, ketamine and fasciculin towards acetylcholinesterase in liposomes and in solution. Biochem Pharmacol. 1990;40:2209-14 pubmed