Brister M, Gustavsson T, Crespo Hernandez C. Excited State Lifetimes of Sulfur-Substituted DNA and RNA Monomers Probed Using the Femtosecond Fluorescence Up-Conversion Technique. Molecules. 2020;25: pubmed publisher

Bajzikova M, Kovarova J, Coelho A, Boukalova S, Oh S, Rohlenova K, et al. Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metab. 2019;29:399-416.e10 pubmed publisher

Li H, Cuevas I, Zhang M, Lu C, Alam M, Fu Y, et al. Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load. J Clin Invest. 2018;128:4179-4191 pubmed publisher

Bajikar S, Wang C, Borten M, Pereira E, Atkins K, Janes K. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Dev Cell. 2017;43:418-435.e13 pubmed publisher

Liu D, Frederiksen J, Liberti S, Lützen A, Keijzers G, Pena Diaz J, et al. Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro. Nucleic Acids Res. 2017;45:9427-9440 pubmed publisher

Kramer M, Masner M, Casales E, Moreno M, Smerdou C, Chabalgoity J. Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice. BMC Cancer. 2015;15:620 pubmed publisher

Vences Catalán F, Rajapaksa R, Srivastava M, Marabelle A, Kuo C, Levy R, et al. Tetraspanin CD81 promotes tumor growth and metastasis by modulating the functions of T regulatory and myeloid-derived suppressor cells. Cancer Res. 2015;75:4517-26 pubmed publisher

Bazley F, Liu C, Yuan X, Hao H, All A, De Los Angeles A, et al. Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells. Stem Cells Dev. 2015;24:2634-48 pubmed publisher

Anastasov N, Höfig I, Radulović V, Ströbel S, Salomon M, Lichtenberg J, et al. A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment. BMC Cancer. 2015;15:466 pubmed publisher

Jeanbart L, Kourtis I, van der Vlies A, Swartz M, Hubbell J. 6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice. Cancer Immunol Immunother. 2015;64:1033-46 pubmed publisher

Bi K, Nishihara K, Machleidt T, Hermanson S, Wang J, Sakamuru S, et al. Identification of known drugs targeting the endoplasmic reticulum stress response. Anal Bioanal Chem. 2015;407:5343-51 pubmed publisher

Sircar D, Gaid M, Chizzali C, Reckwell D, Kaufholdt D, Beuerle T, et al. Biphenyl 4-Hydroxylases Involved in Aucuparin Biosynthesis in Rowan and Apple Are Cytochrome P450 736A Proteins. Plant Physiol. 2015;168:428-42 pubmed publisher

Abu N, Mohamed N, Yeap S, Lim K, Akhtar M, Zulfadli A, et al. In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice. Drug Des Devel Ther. 2015;9:1401-17 pubmed publisher

Scheffler A, Albrecht A, Esch H, Lehmann L. Mutagenic potential of the isoflavone irilone in cultured V79 cells. Toxicol Lett. 2015;234:81-91 pubmed publisher

Mahajan S, Manetsch R, Merkler D, Stevens S. Synthesis and evaluation of a novel adenosine-ribose probe for global-scale profiling of nucleoside and nucleotide-binding proteins. PLoS ONE. 2015;10:e0115644 pubmed publisher

Di Matteo P, Mangia P, Tiziano E, Valentinis B, Porcellini S, Doglioni C, et al. Anti-metastatic activity of the tumor vascular targeting agent NGR-TNF. Clin Exp Metastasis. 2015;32:289-300 pubmed publisher

Sun C, Schattgen S, Pisitkun P, Jorgensen J, Hilterbrand A, Wang L, et al. Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. J Immunol. 2015;194:1819-31 pubmed publisher

Ferrari Amorotti G, Chiodoni C, Shen F, Cattelani S, Soliera A, Manzotti G, et al. Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity. Neoplasia. 2014;16:1047-58 pubmed publisher

Lennard L, Cartwright C, Wade R, Vora A. Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics. Br J Haematol. 2015;169:228-40 pubmed publisher

Gross B, Wongrakpanich A, Francis M, Salem A, Norian L. A therapeutic microparticle-based tumor lysate vaccine reduces spontaneous metastases in murine breast cancer. AAPS J. 2014;16:1194-203 pubmed publisher

Liu L, Zhou W, Cheng C, Ren X, Somlo G, Fong M, et al. TGF? induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes. Mol Cancer Res. 2014;12:1597-609 pubmed publisher

Rytting M, Thomas D, O Brien S, Ravandi Kashani F, Jabbour E, Franklin A, et al. Augmented Berlin-Frankfurt-Münster therapy in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL). Cancer. 2014;120:3660-8 pubmed publisher

Erkekoglu P, Chao M, Ye W, Ge J, Trudel L, Skipper P, et al. Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds. Food Chem Toxicol. 2014;72:98-110 pubmed publisher

Hanafi L, Gauchat D, Godin Ethier J, Possamaï D, Duvignaud J, Leclerc D, et al. Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism. PLoS ONE. 2014;9:e99211 pubmed publisher

Jones C, Bhatla T, Blum R, Wang J, Paugh S, Wen X, et al. Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model. J Biol Chem. 2014;289:20502-15 pubmed

Krutá M, Šeneklová M, Raška J, Salykin A, Zerzankova L, Pesl M, et al. Mutation frequency dynamics in HPRT locus in culture-adapted human embryonic stem cells and induced pluripotent stem cells correspond to their differentiated counterparts. Stem Cells Dev. 2014;23:2443-54 pubmed publisher

Moriarity B, Rahrmann E, Beckmann D, Conboy C, Watson A, Carlson D, et al. Simple and efficient methods for enrichment and isolation of endonuclease modified cells. PLoS ONE. 2014;9:e96114 pubmed publisher

Nagarajan A, Dogra S, Liu A, Green M, Wajapeyee N. PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation. Mol Cell Biol. 2014;34:2264-82 pubmed publisher

Emanuele E. Challenging the central dogma of skin photobiology: are proteins more important than DNA?. J Invest Dermatol. 2014;134:2052-2053 pubmed publisher

Gueranger Q, Li F, Peacock M, Larnicol Fery A, Brem R, MacPherson P, et al. Response to Emanuele. J Invest Dermatol. 2014;134:2053-2055 pubmed publisher

Wensing A, Gernold M, Jock S, Jansen R, Geider K. Identification and genetics of 6-thioguanine secreted by Erwinia species and its interference with the growth of other bacteria. Mol Genet Genomics. 2014;289:215-23 pubmed publisher

Wang T, Wei J, Sabatini D, Lander E. Genetic screens in human cells using the CRISPR-Cas9 system. Science. 2014;343:80-4 pubmed publisher

Gueranger Q, Li F, Peacock M, Larnicol Fery A, Brem R, MacPherson P, et al. Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation. J Invest Dermatol. 2014;134:1408-1417 pubmed publisher

Mao J, Zhao F, Song H, Yang S, Shen D, Tang Y. [Thioguanine treatment-related sinusoidal obstruction syndrome in 2 children]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15:788-90 pubmed

Nguyen T, Nguyen T, Lachaux A, Boulieu R. Usefulness of thiopurine metabolites in predicting azathioprine resistance in pediatric IBD patients. J Clin Pharmacol. 2013;53:900-8 pubmed publisher

Drost M, Lützen A, van Hees S, Ferreira D, Calléja F, Zonneveld J, et al. Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. Proc Natl Acad Sci U S A. 2013;110:9403-8 pubmed publisher

Zou X, Zhao H, Yu Y, Su H. Formation of guanine-6-sulfonate from 6-thioguanine and singlet oxygen: a combined theoretical and experimental study. J Am Chem Soc. 2013;135:4509-15 pubmed publisher

Kavcic M, Fisher B, Li Y, Seif A, Torp K, Walker D, et al. Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States. Cancer. 2013;119:1916-23 pubmed publisher

Bi N, Hu M, Zhu H, Qi H, Tian Y, Zhang H. Determination of 6-thioguanine based on localized surface plasmon resonance of gold nanoparticle. Spectrochim Acta A Mol Biomol Spectrosc. 2013;107:24-30 pubmed publisher

Appell M, Berg J, Duley J, Evans W, Kennedy M, Lennard L, et al. Nomenclature for alleles of the thiopurine methyltransferase gene. Pharmacogenet Genomics. 2013;23:242-8 pubmed publisher

Sann H, Erichsen J, Hessmann M, Pahl A, Hoffmeyer A. Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice. Life Sci. 2013;92:708-18 pubmed publisher

Wang Y, Lin Z, Liu Z, Harris S, Kelly R, Zhang J, et al. A unifying ontology to integrate histological and clinical observations for drug-induced liver injury. Am J Pathol. 2013;182:1180-7 pubmed publisher

de Boer N, van Asseldonk D, Seinen M, van Bodegraven A. Oxidation-mediated DNA crosslinking contributes to toxicity of 6-thioguanine in human cells -- letter. Cancer Res. 2013;73:1445 pubmed publisher

Angelberger S, Schaeffeler E, Teml A, Petritsch W, Shonova O, Lukas M, et al. Mucosal improvement in patients with moderate to severe postoperative endoscopic recurrence of Crohn's disease and azathioprine metabolite levels. Inflamm Bowel Dis. 2013;19:590-8 pubmed publisher

Tzoneva G, Perez Garcia A, Carpenter Z, Khiabanian H, Tosello V, Allegretta M, et al. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med. 2013;19:368-71 pubmed publisher

de Boer Y, van Gerven N, de Boer N, Mulder C, Bouma G, van Nieuwkerk C. Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis. Aliment Pharmacol Ther. 2013;37:640-6 pubmed publisher

Vikingsson S, Almer S, Peterson C, Carlsson B, Josefsson M. Monitoring of thiopurine metabolites - a high-performance liquid chromatography method for clinical use. J Pharm Biomed Anal. 2013;75:145-52 pubmed publisher

Wareham N, Heilmann C, Abrahamsson J, Forestier E, Gustafsson B, Ha S, et al. Outcome of poor response paediatric AML using early SCT. Eur J Haematol. 2013;90:187-94 pubmed publisher

Actis G, Tarallo S, Rosina F. Cutting edge: chemoprevention of colorectal neoplasia in inflammatory bowel disease. Inflamm Allergy Drug Targets. 2013;12:1-7 pubmed

Duley J, Somogyi A, Martin J. The future of thiopurine pharmacogenomics. Pharmacogenomics. 2012;13:1549-52 pubmed publisher

Lengfelder E, Hanfstein B, Haferlach C, Braess J, Krug U, Spiekermann K, et al. Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group. Ann Hematol. 2013;92:41-52 pubmed publisher

You C, Dai X, Yuan B, Wang Y. Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells. J Biol Chem. 2012;287:40915-23 pubmed publisher

Bertino J, Lubin M, Johnson Farley N, Chan W, Goodell L, Bhagavathi S. Lack of expression of MTAP in uncommon T-cell lymphomas. Clin Lymphoma Myeloma Leuk. 2012;12:306-9 pubmed publisher

Benedict A, Knatko E, Dinkova Kostova A. The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress. Carcinogenesis. 2012;33:2457-66 pubmed publisher

Misdaq M, Andag R, Oellerich M, Asif A, von Ahsen N. Establishment of thiopurine S-methyltransferase gene knockdown in jurkat T-lymphocytes: an in vitro model of TPMT polymorphism. Ther Drug Monit. 2012;34:584-92 pubmed publisher

van der Vlies A, Hasegawa U, Hubbell J. Reduction-sensitive tioguanine prodrug micelles. Mol Pharm. 2012;9:2812-8 pubmed

Mooney P, Sanders D, Hadjivassilou M, Lennard L. Commentary: tioguanine in the treatment of refractory coeliac disease. Aliment Pharmacol Ther. 2012;36:594-5; author reply 595 pubmed publisher

Beddows A, PATEL N, Finger L, Atack J, Williams D, Grasby J. Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases. Chem Commun (Camb). 2012;48:8895-7 pubmed publisher

Tang B, Testa J, Kruger W. Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer Biol Ther. 2012;13:1082-90 pubmed publisher

Brem R, Karran P. Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells. Cancer Res. 2012;72:4787-95 pubmed publisher

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher

Brem R, Karran P. Multiple forms of DNA damage caused by UVA photoactivation of DNA 6-thioguanine. Photochem Photobiol. 2012;88:5-13 pubmed publisher

Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W. FDA-approved drug labeling for the study of drug-induced liver injury. Drug Discov Today. 2011;16:697-703 pubmed publisher

Seinen M, van Asseldonk D, Mulder C, de Boer N. Dosing 6-thioguanine in inflammatory bowel disease: expert-based guidelines for daily practice. J Gastrointestin Liver Dis. 2010;19:291-4 pubmed

Alvarez Z, Lee K, Abel Santos E. Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture. Antimicrob Agents Chemother. 2010;54:5329-36 pubmed publisher

Ekins S, Williams A, Xu J. A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 2010;38:2302-8 pubmed publisher

Fakhoury M, de Beaumais T, Medard Y, Jacqz Aigrain E. [Therapeutic drug monitoring of 6-thioguanine nucleotides in paediatric acute lymphoblastic leukaemia: interest and limits]. Therapie. 2010;65:187-93 pubmed publisher

Jourdil N, Fonrose X, Boulieu R, Stanke Labesque F. [Therapeutic drug monitoring of 6-thioguanine nucleotides in inflammatory bowel disease: interest and limits]. Therapie. 2010;65:177-86 pubmed publisher

Brulíková L, Dzubak P, Hajduch M, Lachnitová L, Kollareddy M, Kolar M, et al. Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity. Eur J Med Chem. 2010;45:3588-94 pubmed publisher

Greene N, Fisk L, Naven R, Note R, Patel M, Pelletier D. Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 2010;23:1215-22 pubmed publisher

Toropov A, Toropova A, Raska I, Benfenati E. QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations. Eur J Med Chem. 2010;45:1639-47 pubmed publisher

Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher

Das S, Doshi J, Tian D, Addo S, Srinivasan B, Hermanson D, et al. Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues. J Med Chem. 2009;52:5937-49 pubmed publisher

Bendaly J, Doll M, Millner L, Metry K, Smith N, Pierce W, et al. Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations. Mutat Res. 2009;671:13-9 pubmed publisher

Styczynski J, Gil L, Derwich K, Wachowiak J, Balwierz W, Badowska W, et al. Comparison of clofarabine activity in childhood and adult acute leukemia: individual tumor response study. Anticancer Res. 2009;29:1643-50 pubmed

Santana L, González Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, et al. Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008;51:6740-51 pubmed publisher

Styczynski J, Wysocki M, Dluzniewska A, Juraszewska E, Balwierz W, Czyzewski K, et al. Prognostic impact of combined fludarabine, treosulfan and mitoxantrone resistance profile in childhood acute myeloid leukemia. Anticancer Res. 2008;28:1927-31 pubmed

Aronov A, McClain B, Moody C, Murcko M. Kinase-likeness and kinase-privileged fragments: toward virtual polypharmacology. J Med Chem. 2008;51:1214-22 pubmed publisher

Gil L, Styczynski J, Dytfeld D, Debski R, Kazmierczak M, Kolodziej B, et al. Activity of bortezomib in adult de novo and relapsed acute myeloid leukemia. Anticancer Res. 2007;27:4021-5 pubmed

Styczynski J, Toporski J, Wysocki M, Debski R, Chybicka A, Boruczkowski D, et al. Fludarabine, treosulfan and etoposide sensitivity and the outcome of hematopoietic stem cell transplantation in childhood acute myeloid leukemia. Anticancer Res. 2007;27:1547-51 pubmed

Hsieh J, Wu S, Yang Y, Choong K, Chen S. The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. Bioorg Med Chem. 2007;15:3450-6 pubmed

Maegawa G, Tropak M, Buttner J, Stockley T, Kok F, Clarke J, et al. Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. J Biol Chem. 2007;282:9150-61 pubmed

Doshi J, Tian D, Xing C. Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J Med Chem. 2006;49:7731-9 pubmed

Keough D, Skinner Adams T, Jones M, Ng A, Brereton I, Guddat L, et al. Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. J Med Chem. 2006;49:7479-86 pubmed

Gürsoy E, Güzeldemirci N. Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives. Eur J Med Chem. 2007;42:320-6 pubmed

de Boer N, Reinisch W, Teml A, van Bodegraven A, Schwab M, Lukas M, et al. 6-Thioguanine treatment in inflammatory bowel disease: a critical appraisal by a European 6-TG working party. Digestion. 2006;73:25-31 pubmed

de Boer N, van Nieuwkerk C, Aparicio Pages M, de Boer S, Derijks L, Mulder C. Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine. Eur J Gastroenterol Hepatol. 2005;17:457-61 pubmed

Schwab M, Herrlinger K, Schaeffeler E, Stange E. [Therapy of chronic inflammatory bowel diseases with azathioprine, 6-mercaptopurine and 6-thioguanine. Clinico-pharmacologic aspects]. Dtsch Med Wochenschr. 2003;128:378-85 pubmed

Sherer D, Lebwohl M. 6-thioguanine in the treatment of psoriasis: a case report and literature review. J Cutan Med Surg. 2002;6:546-50 pubmed

Estlin E. Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine. Cancer Treat Rev. 2001;27:351-63 pubmed