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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
1-Aminobenzotriazole
catalog :
A3940
citations: 53
Reference
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Martin Y, Manlove L, Dong J, Carey W, Thompson M, Pabelick C, et al. Hyperoxia-induced changes in estradiol metabolism in postnatal airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015;308:L141-6 pubmed publisher
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Mir Tutusaus J, Masís Mora M, Corcellas C, Eljarrat E, Barceló D, Sarrà M, et al. Degradation of selected agrochemicals by the white rot fungus Trametes versicolor. Sci Total Environ. 2014;500-501:235-42 pubmed publisher
Matsuda Y, Konno Y, Hashimoto T, Nagai M, Taguchi T, Satsukawa M, et al. Quantitative assessment of intestinal first-pass metabolism of oral drugs using portal-vein cannulated rats. Pharm Res. 2015;32:604-16 pubmed publisher
Yamamiya I, Yoshisue K, Ishii Y, Yamada H, Yoshida K. Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys. J Pharm Pharmacol. 2014;66:1686-97 pubmed publisher
Vivares A, Sallé Lefort S, Arabeyre Fabre C, Ngo R, Penarier G, Bremond M, et al. Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. Xenobiotica. 2015;45:29-44 pubmed publisher
Feeney O, Williams H, Pouton C, Porter C. 'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug. J Control Release. 2014;192:219-27 pubmed publisher
Mori K, Kumano A, Kodama T, Takiguchi S, Takano N, Kumada K, et al. Evaluation of hepatic damage by reactive metabolites--with consideration of circadian variation of murine hepatic glutathione levels. J Toxicol Sci. 2014;39:537-44 pubmed
Yoon M, Kedderis G, Yan G, Clewell H. Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study. Toxicology. 2015;332:52-66 pubmed publisher
Orozco L, Liu H, Perkins E, Johnson D, Chen B, Fan F, et al. 20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. J Pharmacol Exp Ther. 2013;346:67-74 pubmed publisher
Martinkova M, Kubickova B, Stiborova M. Effects of cytochrome P450 inhibitors on peroxidase activity. Neuro Endocrinol Lett. 2012;33 Suppl 3:33-40 pubmed
Bylund J, Bueters T. Presystemic metabolism of AZ'0908, a novel mPGES-1 inhibitor: an in vitro and in vivo cross-species comparison. J Pharm Sci. 2013;102:1106-15 pubmed publisher
Yue Q, Mulder T, Rudewicz P, Solon E, Budha N, Ware J, et al. Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: a novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazole. Drug Metab Dispos. 2013;41:508-17 pubmed publisher
Surendradoss J, Chang T, Abbott F. Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes. Toxicol Appl Pharmacol. 2012;264:413-22 pubmed publisher
Li A, Uzgare A, Laforge Y. Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: results with model toxicants aflatoxin B1, . Chem Biol Interact. 2012;199:1-8 pubmed publisher
Fernandez M, Gonzalez D, Williams J, Roman R, Nowicki S. Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. Eur J Pharmacol. 2012;686:97-103 pubmed publisher
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Kimoto E, Walsky R, Zhang H, Bi Y, Whalen K, Yang Y, et al. Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes. Drug Metab Dispos. 2012;40:407-11 pubmed publisher
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Ly V, Brock B. Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. Chem Biol Interact. 2011;193:109-18 pubmed publisher
Li A, Doshi U. Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4. Drug Metab Lett. 2011;5:183-91 pubmed
Sun Q, Harper T, Dierks E, Zhang L, Chang S, Rodrigues A, et al. 1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase. Drug Metab Dispos. 2011;39:1674-9 pubmed publisher
Shi Q, Yang X, Greenhaw J, Salminen W. Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. Toxicol Sci. 2011;122:579-86 pubmed publisher
Mishra S, Manickavasagam L, Jain G. Determination of metabolic profile of anti-malarial trioxane CDRI 99/411 in rat liver microsomes using HPLC. Biomed Chromatogr. 2012;26:115-22 pubmed publisher
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Yang K, Koh K, Jeong H. Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes. Drug Metab Lett. 2010;4:129-33 pubmed
Hahn V, Mikolasch A, Wende K, Bartrow H, Lindequist U, Schauer F. Derivatization of the azole 1-aminobenzotriazole using laccase of Pycnoporus cinnabarinus and Myceliophthora thermophila: influence of methanol on the reaction and biological evaluation of the derivatives. Biotechnol Appl Biochem. 2010;56:43-8 pubmed publisher
Cooper P, Mesaros A, Zhang J, Christmas P, Stark C, Douaidy K, et al. 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. PLoS ONE. 2010;5:e10235 pubmed publisher
Eng H, Niosi M, McDonald T, Wolford A, Chen Y, Simila S, et al. Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor. Xenobiotica. 2010;40:369-80 pubmed publisher
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Mathews J, Dostal L, Bend J. Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J Pharmacol Exp Ther. 1985;235:186-90 pubmed
product information
Catalog Number :
A3940
Product Name :
1-Aminobenzotriazole
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA