This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Aprotinin from bovine lung
catalog :
A3428
citations: 44
Reference
Ronaldson Bouchard K, Ma S, Yeager K, Chen T, Song L, Sirabella D, et al. Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature. 2018;556:239-243 pubmed publisher
Magnussen S, Hadler Olsen E, Costea D, Berg E, Jacobsen C, Mortensen B, et al. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. BMC Cancer. 2017;17:350 pubmed publisher
Somogyi V, Horvath T, Toth I, Bartha T, Frenyó L, Kiss D, et al. Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture. Acta Vet Hung. 2016;64:497-513 pubmed
Somera A, Lima A, Dos Santos Neto Ã, Lanças F, Bacci M. Leaf-cutter ant fungus gardens are biphasic mixed microbial bioreactors that convert plant biomass to polyols with biotechnological applications. Appl Environ Microbiol. 2015;81:4525-35 pubmed publisher
Royston D. The current place of aprotinin in the management of bleeding. Anaesthesia. 2015;70 Suppl 1:46-9, e17 pubmed publisher
. Regulatory decisions pertaining to aprotinin may be putting patients at risk. CMAJ. 2014;186:1379-86 pubmed publisher
Weininger U, Modig K, Akke M. Ring flips revisited: (13)C relaxation dispersion measurements of aromatic side chain dynamics and activation barriers in basic pancreatic trypsin inhibitor. Biochemistry. 2014;53:4519-25 pubmed publisher
Leroux P, Omouendze P, Roy V, Dourmap N, Gonzalez B, Brasse Lagnel C, et al. Age-dependent neonatal intracerebral hemorrhage in plasminogen activator inhibitor 1 knockout mice. J Neuropathol Exp Neurol. 2014;73:387-402 pubmed publisher
Two A, Hata T, Nakatsuji T, Coda A, Kotol P, Wu W, et al. Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor. J Invest Dermatol. 2014;134:1143-1145 pubmed publisher
Sunyakumthorn P, Petchampai N, Grasperge B, Kearney M, Sonenshine D, Macaluso K. Gene expression of tissue-specific molecules in ex vivo Dermacentor variabilis (Acari: Ixodidae) during rickettsial exposure. J Med Entomol. 2013;50:1089-96 pubmed
Molnar T, Vörös J, Szeder B, Takáts K, Kardos J, Katona G, et al. Comparison of complexes formed by a crustacean and a vertebrate trypsin with bovine pancreatic trypsin inhibitor - the key to achieving extreme stability?. FEBS J. 2013;280:5750-63 pubmed publisher
Cheng A, Tsai I. Functional characterization of a slow and tight-binding inhibitor of plasmin isolated from Russell's viper venom. Biochim Biophys Acta. 2014;1840:153-9 pubmed publisher
Pagano D, Freemantle N. Reply to the editor. J Thorac Cardiovasc Surg. 2013;146:732 pubmed publisher
Catalá López F. Clinical evidence from randomized trials, network meta-analyses, and conflicts of interests. J Thorac Cardiovasc Surg. 2013;146:731-2 pubmed publisher
Kaya H, Kafali M, Aydin K, Kocak S, Sahin M, Duran A, et al. Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rabbits. J Pak Med Assoc. 2013;63:32-7 pubmed
Walker A. Matching on provider is risky. J Clin Epidemiol. 2013;66:S65-8 pubmed publisher
Rosén M. EMA, transparency, and decision-making process. Lancet. 2013;382:26-7 pubmed publisher
Khan M, Islam M, Kuroda Y. Analysis of protein aggregation kinetics using short amino acid peptide tags. Biochim Biophys Acta. 2013;1834:2107-15 pubmed publisher
Ohnishi Y, Yamada T, Kurihara K, Tanaka I, Sakiyama F, Masaki T, et al. Neutron and X-ray crystallographic analysis of Achromobacter protease I at pD 8.0: protonation states and hydration structure in the free-form. Biochim Biophys Acta. 2013;1834:1642-7 pubmed publisher
Ortmann E, Besser M, Klein A. Antifibrinolytic agents in current anaesthetic practice. Br J Anaesth. 2013;111:549-63 pubmed publisher
McMullan V, Alston R. III. Aprotinin and cardiac surgery: a sorry tale of evidence misused. Br J Anaesth. 2013;110:675-8 pubmed publisher
Sathyamoorthy B, Singarapu K, Garcia A, Szyperski T. Protein conformational space populated in solution probed with aromatic residual dipolar (13) C-(1) H couplings. Chembiochem. 2013;14:684-8 pubmed publisher
Meybohm P, Herrmann E, Nierhoff J, Zacharowski K. Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients. PLoS ONE. 2013;8:e58009 pubmed publisher
Roberts I, Shakur H, Ker K, Coats T. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2012;12:CD004896 pubmed
Millers E, Johnson L, Birrell G, Masci P, Lavin M, de Jersey J, et al. The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS ONE. 2013;8:e54104 pubmed publisher
Later A, Sitniakowsky L, van Hilten J, van de Watering L, Brand A, Smit N, et al. Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery. J Thorac Cardiovasc Surg. 2013;145:1611-6, 1616.e1-4 pubmed publisher
Tvarijonaviciute A, Martinez Subiela S, Ceron J. Influence of different storage conditions and anticoagulants on the measurement of total and acylated ghrelin in dogs: a preliminary study. Vet Rec. 2013;172:289 pubmed publisher
Catalá López F. Safety of aprotinin in adult cardiac surgery: revisiting the validity of a mixed-treatment comparison meta-analysis. J Thorac Cardiovasc Surg. 2013;145:610 pubmed publisher
Wan H, Lee K, Kim B, Zou F, Yoon H, Je Y, et al. A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor. PLoS ONE. 2013;8:e53343 pubmed publisher
Matsuda T, Watanabe S, Kigawa T. Cell-free synthesis system suitable for disulfide-containing proteins. Biochem Biophys Res Commun. 2013;431:296-301 pubmed publisher
Glotzbach B, Schmelz S, Reinwarth M, Christmann A, Heinz D, Kolmar H. Structural characterization of Spinacia oleracea trypsin inhibitor III (SOTI-III). Acta Crystallogr D Biol Crystallogr. 2013;69:114-20 pubmed publisher
Dauter Z. Placement of molecules in (not out of) the cell. Acta Crystallogr D Biol Crystallogr. 2013;69:2-4 pubmed publisher
Reinwarth M, Glotzbach B, Tomaszowski M, Fabritz S, Avrutina O, Kolmar H. Oxidative folding of peptides with cystine-knot architectures: kinetic studies and optimization of folding conditions. Chembiochem. 2013;14:137-46 pubmed publisher
Bhunia B, Basak B, Mandal T, Bhattacharya P, Dey A. Effect of pH and temperature on stability and kinetics of novel extracellular serine alkaline protease (70 kDa). Int J Biol Macromol. 2013;54:1-8 pubmed publisher
Martin K, Gertler R, MacGuill M, Mayr N, Hapfelmeier A, Hörer J, et al. Replacement of aprotinin by ε-aminocaproic acid in infants undergoing cardiac surgery: consequences for blood loss and outcome. Br J Anaesth. 2013;110:615-21 pubmed publisher
Fan Y, Lin R, Yang L, Ye L, Yu J, Shu Q. Retrospective cohort analysis of a single dose of aprotinin use in children undergoing cardiac surgery: a single-center experience. Paediatr Anaesth. 2013;23:242-9 pubmed publisher
Lecker I, Wang D, Romaschin A, Peterson M, Mazer C, Orser B. Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. J Clin Invest. 2012;122:4654-66 pubmed publisher
Later A, Bruggemans E, Romijn F, Van Pelt J, Klautz R. A comparative study of the immune modulating properties of antifibrinolytics in cardiac surgery. Cytokine. 2013;61:438-44 pubmed publisher
Ranasinghe S, McManus D. Structure and function of invertebrate Kunitz serine protease inhibitors. Dev Comp Immunol. 2013;39:219-27 pubmed publisher
Maruna P, Klein A, Kunstyr J, Plocová K, Mlejnsky F, Lindner J. Aprotinin reduces the procalcitonin rise associated with complex cardiac surgery and cardiopulmonary bypass. Physiol Res. 2013;62:27-33 pubmed
Fenley A, Muddana H, Gilson M. Entropy-enthalpy transduction caused by conformational shifts can obscure the forces driving protein-ligand binding. Proc Natl Acad Sci U S A. 2012;109:20006-11 pubmed publisher
Riddell R, Buth K, Sullivan J. The risks associated with aprotinin use: a retrospective study of cardiac cases in Nova Scotia. Can J Anaesth. 2013;60:16-23 pubmed publisher
Beckerman Z, Shopen Y, Alon H, Cohen O, Nir R, Adler Z, et al. Coronary artery bypass grafting after aprotinin: are we doing better?. J Thorac Cardiovasc Surg. 2013;145:243-8 pubmed publisher
Del Bigio M, Enno T. Effect of hydrocephalus on rat brain extracellular compartment. Cerebrospinal Fluid Res. 2008;5:12 pubmed publisher
product information
Catalog Number :
A3428
Product Name :
Aprotinin from bovine lung
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
lyophilized powder, 3-8 TIU/mg solid, BioReagent, suitable for cell culture
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA