This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
catalog :
A3281
citations: 41
Reference
Kyrmizi I, Ferreira H, Carvalho A, Figueroa J, Zarmpas P, Cunha C, et al. Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis. Nat Microbiol. 2018;3:791-803 pubmed publisher
Sun X, Yang Y, Zhong X, Cao Q, Zhu X, Zhu X, et al. A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism. Autophagy. 2018;14:38-52 pubmed publisher
Zheng K, Jiang Y, Liao C, Hu X, Li Y, Zeng Y, et al. NOX2-Mediated TFEB Activation and Vacuolization Regulate Lysosome-Associated Cell Death Induced by Gypenoside L, a Saponin Isolated from Gynostemma pentaphyllum. J Agric Food Chem. 2017;65:6625-6637 pubmed publisher
Nadeau Vallée M, Boudreault A, Leimert K, Hou X, Obari D, Madaan A, et al. Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth. Biol Reprod. 2016;95:72 pubmed
Hirayama M, Ogata M, Kawamata T, Ishibashi H. Muscarinic receptor-mediated excitation of rat intracardiac ganglion neurons. Neuropharmacology. 2015;95:395-404 pubmed publisher
Dwyer D, Awatramani P, Thakur R, Seeni R, Aamodt E. Social feeding in Caenorhabditis elegans is modulated by antipsychotic drugs and calmodulin and may serve as a protophenotype for asociality. Neuropharmacology. 2015;92:56-62 pubmed publisher
Yokokura S, Yurimoto S, Matsuoka A, Imataki O, Dobashi H, Bandoh S, et al. Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma. BMC Cancer. 2014;14:882 pubmed publisher
Wang X, Boyken S, Hu J, Xu X, Rimer R, Shea M, et al. Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. Sci Signal. 2014;7:ra74 pubmed publisher
Liu W, Zhao H, Wang Y, Jiang C, Xia P, Gu J, et al. Calcium-calmodulin signaling elicits mitochondrial dysfunction and the release of cytochrome c during cadmium-induced apoptosis in primary osteoblasts. Toxicol Lett. 2014;224:1-6 pubmed publisher
Coen M, Marchetti G, Palagi P, Zerbinati C, Guastella G, Gagliano T, et al. Calmodulin expression distinguishes the smooth muscle cell population of human carotid plaque. Am J Pathol. 2013;183:996-1009 pubmed publisher
García Palmero I, Villalobo A. Deletion of the calmodulin-binding domain of Grb7 impairs cell attachment to the extracellular matrix and migration. Biochem Biophys Res Commun. 2013;436:271-7 pubmed publisher
Mou P, Zeng Z, Li Q, Liu X, Xin X, WANNEMACHER K, et al. Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets. Blood. 2013;121:4221-30 pubmed publisher
Bogatcheva P, Balezina O. Multidirectional effects of calmodulin kinase II on transmitter release in mature and newly formed mouse motor synapses. Bull Exp Biol Med. 2013;154:316-9 pubmed
Farrer R, Farrer J, DeVries G. Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14. J Biol Chem. 2013;288:11066-73 pubmed publisher
Mancinelli R, Franchitto A, Glaser S, Meng F, Onori P, Demorrow S, et al. GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8. Hepatology. 2013;58:251-63 pubmed publisher
Arai T, Uehata M, Akatsuka H, Kamiyama T. A quantitative analysis to unveil specific binding proteins for bioactive compounds. Protein Eng Des Sel. 2013;26:249-54 pubmed publisher
Pinto C, Reif G, Nivens E, White C, Wallace D. Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells. Am J Physiol Renal Physiol. 2012;303:F1412-24 pubmed publisher
Pilla A. Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems. Biochem Biophys Res Commun. 2012;426:330-3 pubmed publisher
Bourgonje V, Schoenmakers M, Beekman J, van der Nagel R, Houtman M, Miedema L, et al. Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart Rhythm. 2012;9:1875-83 pubmed publisher
Gonzalez Fernandez L, Macias Garcia B, Velez I, Varner D, Hinrichs K. Calcium-calmodulin and pH regulate protein tyrosine phosphorylation in stallion sperm. Reproduction. 2012;144:411-22 pubmed publisher
Russell S, McFerran N, Moore C, Tsang Y, Glass P, Hoey E, et al. A novel calmodulin-like protein from the liver fluke, Fasciola hepatica. Biochimie. 2012;94:2398-406 pubmed publisher
Lasko J, Schlingmann K, Klocke A, Mengel G, TURNER R. Calcium/calmodulin and cAMP/protein kinase-A pathways regulate sperm motility in the stallion. Anim Reprod Sci. 2012;132:169-77 pubmed publisher
Sheremet I, Emets A, Azmi A, Vissenberg K, Verbelen J, Blium I. [Effect of inhibitors serine/threonine protein kinases and protein phosphatases on mitosis progression of synchronized tobacco by-2 cells]. Tsitol Genet. 2012;46:3-11 pubmed
Sasakura D, Nunomura W, Takakuwa Y. Dynamic secondary structural changes in Ca²⁺-saturated calmodulin upon interaction with the antagonist, W-7. Biochem Biophys Res Commun. 2012;423:360-5 pubmed publisher
Poloz Y, O Day D. Ca2+ signaling regulates ecmB expression, cell differentiation and slug regeneration in Dictyostelium. Differentiation. 2012;84:163-75 pubmed publisher
Chen Z, Wang H, Qian P. Characterization and expression of calmodulin gene during larval settlement and metamorphosis of the polychaete Hydroides elegans. Comp Biochem Physiol B Biochem Mol Biol. 2012;162:113-9 pubmed publisher
Srideshikan S, Vanishree V, Jayabaskaran C. Biochemical characterization of a recombinant Swainsona canescens calcium-dependent protein kinase (ScCPK1). Plant Physiol Biochem. 2012;54:27-33 pubmed publisher
Oki K, Plonczynski M, Luis Lam M, Gomez Sanchez E, Gomez Sanchez C. Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology. 2012;153:1774-82 pubmed publisher
Parvin S, Lee O, Sathiyaraj G, Khorolragchaa A, Kim Y, Devi B, et al. Interrelationship between calmodulin (CaM) and H2O2 in abscisic acid-induced antioxidant defense in the seedlings of Panax ginseng. Mol Biol Rep. 2012;39:7327-38 pubmed publisher
Schuler D, Lübker C, Lushington G, Tang W, Shen Y, Richter M, et al. Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I. Biochem Pharmacol. 2012;83:839-848 pubmed publisher
Petroutsos D, Busch A, Janssen I, Trompelt K, Bergner S, Weinl S, et al. The chloroplast calcium sensor CAS is required for photoacclimation in Chlamydomonas reinhardtii. Plant Cell. 2011;23:2950-63 pubmed publisher
Zhai Y, Chen J, Zhang H, Zhang J, Zhang Q, Xiu R. [In vitro effect of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide on differentiation from human adipose-derived mesenchymal stem cells to endothelial cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011;33:306-12 pubmed publisher
Fernandez Velasco M, Ruiz Hurtado G, Rueda A, Neco P, Mercado Morales M, Delgado C, et al. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS ONE. 2011;6:e20863 pubmed publisher
Jaumouillé V, Krishnan D, Alexander R. The calmodulin antagonist W-7 inhibits the epithelial Na+/H+ exchanger via modulating membrane surface potential. Channels (Austin). 2011;5:308-13 pubmed publisher
Alavi S, Gela D, Rodina M, Linhart O. Roles of osmolality, calcium - Potassium antagonist and calcium in activation and flagellar beating pattern of sturgeon sperm. Comp Biochem Physiol A Mol Integr Physiol. 2011;160:166-74 pubmed publisher
Tsuji Y, Hojo M, Voigt N, El Armouche A, Inden Y, Murohara T, et al. Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation. 2011;123:2192-203 pubmed publisher
Sivanandam A, Murthy S, Chinnakannu K, Bai V, Kim S, Barrack E, et al. Calmodulin protects androgen receptor from calpain-mediated breakdown in prostate cancer cells. J Cell Physiol. 2011;226:1889-96 pubmed publisher
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
Suzuki Y, Wang W, Morad M. Modulation of Ca2+ channel-gated Ca2+ release by W-7 in cardiac myocytes. Cell Calcium. 1999;25:191-8 pubmed
Osawa M, Kuwamoto S, Izumi Y, Yap K, Ikura M, Shibanuma T, et al. Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding. FEBS Lett. 1999;442:173-7 pubmed
Wang L, Rothberg K, Anderson R. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol. 1993;123:1107-17 pubmed
product information
Catalog Number :
A3281
Product Name :
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA