Bollenbach A, Cordts K, Hanff E, Atzler D, Choe C, Schwedhelm E, et al. Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans. Anal Biochem. 2019;577:59-66 pubmed publisher

Gao S, Mao F, Zhang B, Zhang L, Zhang X, Wang M, et al. Mouse bone marrow-derived mesenchymal stem cells induce macrophage M2 polarization through the nuclear factor-κB and signal transducer and activator of transcription 3 pathways. Exp Biol Med (Maywood). 2014;239:366-75 pubmed publisher

Huang J, Tsai Y, Chang Y, Wu J, Hung J, Lin K, et al. α-Galactosylceramide but not phenyl-glycolipids induced NKT cell anergy and IL-33-mediated myeloid-derived suppressor cell accumulation via upregulation of egr2/3. J Immunol. 2014;192:1972-81 pubmed publisher

Uddin M, Zhang Y, Harton J, MacNamara K, Avram D. TNF-?-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. J Immunol. 2014;192:1946-53 pubmed publisher

Hu X, Li B, Li X, Zhao X, Wan L, Lin G, et al. Transmembrane TNF-? promotes suppressive activities of myeloid-derived suppressor cells via TNFR2. J Immunol. 2014;192:1320-31 pubmed publisher

Na S, Kim O, Ryoo S, Kweon T, Choi Y, Shim H, et al. Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways. Hypertension. 2014;63:309-15 pubmed publisher

Fatima N, Cohen C, Siddiqui M. Arginase-1: a highly specific marker separating pancreatic adenocarcinoma from hepatocellular carcinoma. Acta Cytol. 2014;58:83-8 pubmed publisher

Lisi L, Tramutola A, Navarra P, Dello Russo C. Antiretroviral agents increase NO production in gp120/IFN?-stimulated cultures of rat microglia via an arginase-dependent mechanism. J Neuroimmunol. 2014;266:24-32 pubmed publisher

Hai Y, Dugery R, Healy D, Christianson D. Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme. Biochemistry. 2013;52:9294-309 pubmed publisher

Wu T, Yang Y. [Advances in clinical and molecular genetics studies on argininemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15:954-9 pubmed

Skivka L, Fedorchuk O, Rudyk M, Pozur V, Khranovska N, Grom M, et al. Antineoplastic drug NSC631570 modulates functions of hypoxic macrophages. Tsitol Genet. 2013;47:70-82 pubmed

Elahi S, Ertelt J, Kinder J, Jiang T, Zhang X, Xin L, et al. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection. Nature. 2013;504:158-62 pubmed publisher

Sonnenberg G. Editorial: New tricks for innate lymphoid cells. J Leukoc Biol. 2013;94:862-4 pubmed publisher

Obata Ninomiya K, Ishiwata K, Tsutsui H, Nei Y, Yoshikawa S, Kawano Y, et al. The skin is an important bulwark of acquired immunity against intestinal helminths. J Exp Med. 2013;210:2583-95 pubmed publisher

Hosoi A, Matsushita H, Shimizu K, Fujii S, Ueha S, Abe J, et al. Adoptive cytotoxic T lymphocyte therapy triggers a counter-regulatory immunosuppressive mechanism via recruitment of myeloid-derived suppressor cells. Int J Cancer. 2014;134:1810-22 pubmed publisher

Schaale K, Brandenburg J, Kispert A, Leitges M, Ehlers S, Reiling N. Wnt6 is expressed in granulomatous lesions of Mycobacterium tuberculosis-infected mice and is involved in macrophage differentiation and proliferation. J Immunol. 2013;191:5182-95 pubmed publisher

Zeng X, Li Y, Fan J, Zhao H, Xian Z, Sun Y, et al. Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin's lymphoma cells. Cell Death Dis. 2013;4:e840 pubmed publisher

Mohseni J, Boon Hock C, Abdul Razak C, Othman S, Hayati F, Peitee W, et al. Novel complex re-arrangement of ARG1 commonly shared by unrelated patients with hyperargininemia. Gene. 2014;533:240-5 pubmed publisher

Zhang F, Tang N, Wang X, Li X, Chen Y. Simultaneous recovery of dual pathways for ammonia metabolism do not improve further detoxification of ammonia in HepG2 cells. Hepatobiliary Pancreat Dis Int. 2013;12:525-32 pubmed

Sousa L, Carneiro M, Resende M, Martins L, dos Santos L, Vaz L, et al. Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice. Parasite Immunol. 2014;36:13-31 pubmed publisher

McWhorter F, Wang T, Nguyen P, Chung T, Liu W. Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A. 2013;110:17253-8 pubmed publisher

Cowburn A, Takeda N, Boutin A, Kim J, Sterling J, Nakasaki M, et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013;110:17570-5 pubmed publisher

Moura V, Silva M, Batista L, Gomes C, Leenen P, Lino R, et al. Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection. Exp Parasitol. 2013;135:599-605 pubmed publisher

Castiglione R, Maron Gutierrez T, Barbosa C, Ornellas F, Barreira A, Dibarros C, et al. Bone marrow-derived mononuclear cells promote improvement in glomerular function in rats with early diabetic nephropathy. Cell Physiol Biochem. 2013;32:699-718 pubmed publisher

Wang X, Tang N, Zhang F, Li X, Chen Y. Therapeutic evaluation of a microbioartificial liver with recombinant HepG2 cells for rats with hepatic failure. Expert Opin Biol Ther. 2013;13:1507-13 pubmed publisher

Cary D, Clements J, Henderson A. RON receptor tyrosine kinase, a negative regulator of inflammation, is decreased during simian immunodeficiency virus-associated central nervous system disease. J Immunol. 2013;191:4280-7 pubmed publisher

Chen H, Chen H, Wang L, Wang F, Fang L, Lai H, et al. Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines. J Immunol. 2013;190:5065-77 pubmed publisher

Mariotti F, Petzke K, Bonnet D, Szezepanski I, Bos C, Huneau J, et al. Kinetics of the utilization of dietary arginine for nitric oxide and urea synthesis: insight into the arginine-nitric oxide metabolic system in humans. Am J Clin Nutr. 2013;97:972-9 pubmed publisher

Mao H, Gao W, Lu G, Fang F, Teng L. Clinicopathological and prognostic implications of arginase expression in hepatocellular carcinoma. Clin Lab. 2013;59:37-43 pubmed

Van Zandt M, Whitehouse D, Golebiowski A, Ji M, Zhang M, Beckett R, et al. Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013;56:2568-80 pubmed publisher

Mou Z, Muleme H, Liu D, Jia P, Okwor I, Kuriakose S, et al. Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion. J Immunol. 2013;190:3380-9 pubmed publisher

Vasquez Dunddel D, Pan F, Zeng Q, Gorbounov M, Albesiano E, Fu J, et al. STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest. 2013;123:1580-9 pubmed

Roman A, Kuśmierczyk J, Klimek E, Rogóż Z, Nalepa I. Effects of co-administration of fluoxetine and risperidone on properties of peritoneal and pleural macrophages in rats subjected to the forced swimming test. Pharmacol Rep. 2012;64:1368-80 pubmed

Christiansson L, Söderlund S, Svensson E, Mustjoki S, Bengtsson M, Simonsson B, et al. Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia. PLoS ONE. 2013;8:e55818 pubmed publisher

Lev S, Desmarini D, Li C, Chayakulkeeree M, Traven A, Sorrell T, et al. Phospholipase C of Cryptococcus neoformans regulates homeostasis and virulence by providing inositol trisphosphate as a substrate for Arg1 kinase. Infect Immun. 2013;81:1245-55 pubmed publisher

Wells J, Evans C, Scott M, Rütgen B, O Brien T, Modiano J, et al. Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation. PLoS ONE. 2013;8:e54464 pubmed publisher

Takele Y, Abebe T, Weldegebreal T, Hailu A, Hailu W, Hurissa Z, et al. Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection. PLoS Negl Trop Dis. 2013;7:e1977 pubmed publisher

Chang J, Thangamani S, Kim M, Ulrich B, Morris S, Kim C. Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation. Eur J Immunol. 2013;43:967-78 pubmed publisher

Lee T, Kwon H, Zong H, Yamada E, Vatish M, Pessin J, et al. Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. Diabetes. 2013;62:1537-46 pubmed publisher

Srivastava A, Meena S, Alam M, Nayeem S, Deep S, Sau A. Structural and functional insights into the regulation of Helicobacter pylori arginase activity by an evolutionary nonconserved motif. Biochemistry. 2013;52:508-19 pubmed publisher

Kappe C, Tracy L, Patrone C, Iverfeldt K, Sjoholm A. GLP-1 secretion by microglial cells and decreased CNS expression in obesity. J Neuroinflammation. 2012;9:276 pubmed publisher

Narita Y, Kitamura H, Wakita D, Sumida K, Masuko K, Terada S, et al. The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice. J Immunol. 2013;190:812-20 pubmed publisher

Wang L, Chang E, Wong S, Ong S, Chong D, Ling K. Increased myeloid-derived suppressor cells in gastric cancer correlate with cancer stage and plasma S100A8/A9 proinflammatory proteins. J Immunol. 2013;190:794-804 pubmed publisher

Jung S, Saxena A, Kaur K, Fletcher E, Ponemone V, Nottingham J, et al. The role of adipose tissue-associated macrophages and T lymphocytes in the pathogenesis of inflammatory bowel disease. Cytokine. 2013;61:459-68 pubmed publisher

McKenna K, Beatty K, Scherder R, Li F, Liu H, Chen A, et al. Ascorbate in aqueous humor augments nitric oxide production by macrophages. J Immunol. 2013;190:556-64 pubmed publisher

Källberg E, Stenstrom M, Liberg D, Ivars F, Leanderson T. CD11b+Ly6C++Ly6G- cells show distinct function in mice with chronic inflammation or tumor burden. BMC Immunol. 2012;13:69 pubmed publisher

Akazawa Y, Kubo M, Zhang R, Matsumoto K, Yan F, Setiawan H, et al. Inhibition of arginase ameliorates experimental ulcerative colitis in mice. Free Radic Res. 2013;47:137-45 pubmed publisher

Srivastava S, Ratha B. Unusual hepatic mitochondrial arginase in an Indian air-breathing teleost, Heteropneustes fossilis: purification and characterization. Comp Biochem Physiol B Biochem Mol Biol. 2013;164:133-41 pubmed publisher

Shemyakin A, Kövamees O, Rafnsson A, Bohm F, Svenarud P, Settergren M, et al. Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus. Circulation. 2012;126:2943-50 pubmed publisher

Weisser S, McLarren K, Kuroda E, Sly L. Generation and characterization of murine alternatively activated macrophages. Methods Mol Biol. 2013;946:225-39 pubmed publisher

Yamamoto Y, Sousse L, Enkhbaatar P, Kraft E, Deyo D, Wright C, et al. γ-tocopherol nebulization decreases oxidative stress, arginase activity, and collagen deposition after burn and smoke inhalation in the ovine model. Shock. 2012;38:671-6 pubmed publisher

Burkard T, Planyavsky M, Kaupe I, Breitwieser F, Burckstummer T, Bennett K, et al. Initial characterization of the human central proteome. BMC Syst Biol. 2011;5:17 pubmed publisher

Zakharian T, Di Costanzo L, Christianson D. Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I. Org Biomol Chem. 2008;6:3240-3 pubmed publisher

Di Costanzo L, Moulin M, Haertlein M, Meilleur F, Christianson D. Expression, purification, assay, and crystal structure of perdeuterated human arginase I. Arch Biochem Biophys. 2007;465:82-9 pubmed

Di Costanzo L, Pique M, Christianson D. Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster. J Am Chem Soc. 2007;129:6388-9 pubmed

Di Costanzo L, Sabio G, Mora A, Rodriguez P, Ochoa A, Centeno F, et al. Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. Proc Natl Acad Sci U S A. 2005;102:13058-63 pubmed

Gerhard D, Wagner L, Feingold E, Shenmen C, Grouse L, Schuler G, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004;14:2121-7 pubmed

Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004;36:40-5 pubmed

Mungall A, Palmer S, Sims S, Edwards C, Ashurst J, Wilming L, et al. The DNA sequence and analysis of human chromosome 6. Nature. 2003;425:805-11 pubmed

Cabello J, Basilio C, PRAJOUX V. Kinetic properties of erythrocyte- and liver arginase. Biochim Biophys Acta. 1961;48:148-52 pubmed

Bach S, KILLIP J. Studies on the purification and the kinetic properties of arginase from beef, sheep and horse liver. Biochim Biophys Acta. 1961;47:336-43 pubmed

Greenberg D, BAGOT A, Roholt O. Liver arginase. III. Properties of highly purified arginase. Arch Biochem Biophys. 1956;62:446-53 pubmed

Cama E, Colleluori D, Emig F, Shin H, Kim S, Kim N, et al. Human arginase II: crystal structure and physiological role in male and female sexual arousal. Biochemistry. 2003;42:8445-51 pubmed

Morris S, Bhamidipati D, Kepka Lenhart D. Human type II arginase: sequence analysis and tissue-specific expression. Gene. 1997;193:157-61 pubmed

Vockley J, Jenkinson C, Shukla H, Kern R, Grody W, Cederbaum S. Cloning and characterization of the human type II arginase gene. Genomics. 1996;38:118-23 pubmed

Gotoh T, Sonoki T, Nagasaki A, Terada K, Takiguchi M, Mori M. Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. FEBS Lett. 1996;395:119-22 pubmed

Uchino T, Snyderman S, Lambert M, Qureshi I, Shapira S, Sansaricq C, et al. Molecular basis of phenotypic variation in patients with argininemia. Hum Genet. 1995;96:255-60 pubmed

Dumitru I. Study of L-arginine amidinohydrolase from vegetable origin. Purification, crystallization and molecular weight. Acta Vitaminol Enzymol. 1973;27:207-10 pubmed

Haraguchi Y, Takiguchi M, Amaya Y, Kawamoto S, Matsuda I, Mori M. Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc Natl Acad Sci U S A. 1987;84:412-5 pubmed

Takiguchi M, Haraguchi Y, Mori M. Human liver-type arginase gene: structure of the gene and analysis of the promoter region. Nucleic Acids Res. 1988;16:8789-802 pubmed

Ikemoto M, Tabata M, Miyake T, Kono T, Mori M, Totani M, et al. Expression of human liver arginase in Escherichia coli. Purification and properties of the product. Biochem J. 1990;270:697-703 pubmed

Grody W, Klein D, Dodson A, Kern R, Wissmann P, Goodman B, et al. Molecular genetic study of human arginase deficiency. Am J Hum Genet. 1992;50:1281-90 pubmed

Uchino T, Haraguchi Y, Aparicio J, Mizutani N, Higashikawa M, Naitoh H, et al. Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia. Am J Hum Genet. 1992;51:1406-12 pubmed