Nagasaki A, Kato Y, Meguro K, Yamagishi A, Nakamura C, Uyeda T. A genome editing vector that enables easy selection and identification of knockout cells. Plasmid. 2018;98:37-44 pubmed publisher

Insolia V, Priori E, Gasperini C, Coppa F, Cocchia M, Iervasi E, et al. Prolidase enzyme is required for extracellular matrix integrity and impacts on postnatal cerebellar cortex development. J Comp Neurol. 2020;528:61-80 pubmed publisher

Cohen Katsenelson K, Stender J, Kawashima A, Lordén G, Uchiyama S, Nizet V, et al. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. elife. 2019;8: pubmed publisher

Long J, Idoko Akoh A, Mistry B, Goldhill D, Staller E, Schreyer J, et al. Species specific differences in use of ANP32 proteins by influenza A virus. elife. 2019;8: pubmed publisher

Stefanius K, Servage K, de Souza Santos M, Gray H, Toombs J, Chimalapati S, et al. Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation. elife. 2019;8: pubmed publisher

Li Y, Wang L, Rivera Serrano E, Chen X, Lemon S. TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA. Nucleic Acids Res. 2019;47:6411-6424 pubmed publisher

Udden S, Kwak Y, Godfrey V, Khan M, Khan S, Loof N, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. elife. 2019;8: pubmed publisher

Mauer J, Sindelar M, Despic V, Guez T, Hawley B, Vasseur J, et al. FTO controls reversible m6Am RNA methylation during snRNA biogenesis. Nat Chem Biol. 2019;15:340-347 pubmed publisher

Herb M, Gluschko A, Wiegmann K, Farid A, Wolf A, Utermöhlen O, et al. Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO. Sci Signal. 2019;12: pubmed publisher

Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey M, et al. Miro proteins prime mitochondria for Parkin translocation and mitophagy. EMBO J. 2019;38: pubmed publisher

Petrillo C, Thorne L, Unali G, Schiroli G, Giordano A, Piras F, et al. Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells. Cell Stem Cell. 2018;23:820-832.e9 pubmed publisher

Ablain J, Xu M, Rothschild H, JORDAN R, Mito J, Daniels B, et al. Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018;362:1055-1060 pubmed publisher

Real R, Peter M, Trabalza A, Khan S, Smith M, Dopp J, et al. In vivo modeling of human neuron dynamics and Down syndrome. Science. 2018;362: pubmed publisher

Sammaibashi S, Yamayoshi S, Kawaoka Y. Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins. Front Microbiol. 2018;9:1446 pubmed publisher

Chong S, Dugast Darzacq C, Liu Z, Dong P, Dailey G, Cattoglio C, et al. Imaging dynamic and selective low-complexity domain interactions that control gene transcription. Science. 2018;361: pubmed publisher

Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136 pubmed publisher

Gallagher E, Zelenko Z, Neel B, Antoniou I, Rajan L, Kase N, et al. Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. Oncogene. 2017;36:6462-6471 pubmed publisher

Chen J, Zhong M, Guo H, Davidson D, Mishel S, Lu Y, et al. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017;544:493-497 pubmed publisher

Fusco D, Pratt H, Kandilas S, Cheon S, Lin W, Cronkite D, et al. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Front Microbiol. 2017;8:240 pubmed publisher

Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher

Cabrera J, Lucas J. MAP2 Splicing is Altered in Huntington's Disease. Brain Pathol. 2017;27:181-189 pubmed publisher

Bilardi R, Anstee N, Glaser S, Robati M, Vandenberg C, Cory S. Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice. Cell Death Dis. 2016;7:e2351 pubmed publisher

Frydryskova K, Masek T, Borcin K, Mrvova S, Venturi V, Pospisek M. Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules. BMC Mol Biol. 2016;17:21 pubmed publisher

Valencia Gattas M, Conner G, Fregien N. Gefitinib, an EGFR Tyrosine Kinase inhibitor, Prevents Smoke-Mediated Ciliated Airway Epithelial Cell Loss and Promotes Their Recovery. PLoS ONE. 2016;11:e0160216 pubmed publisher

Kariya Y, Tatsuta T, Sugawara S, Kariya Y, Nitta K, Hosono M. RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells. Int J Oncol. 2016;49:1334-42 pubmed publisher

Yuan Y, Wang Y, Liu Q, Zhu F, Hong Y. Singapore grouper iridovirus protein VP088 is essential for viral infectivity. Sci Rep. 2016;6:31170 pubmed publisher

Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, et al. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. 2016;7:12237 pubmed publisher

Galambos C, Minic A, Bush D, Nguyen D, Dodson B, Seedorf G, et al. Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension. PLoS ONE. 2016;11:e0159005 pubmed publisher

Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher

Kumar R, Agrawal T, Khan N, Nakayama Y, Medigeshi G. Identification and characterization of the role of c-terminal Src kinase in dengue virus replication. Sci Rep. 2016;6:30490 pubmed publisher

Zhou Q, Chai W. Suppression of STN1 enhances the cytotoxicity of chemotherapeutic agents in cancer cells by elevating DNA damage. Oncol Lett. 2016;12:800-808 pubmed

Liu X, Ehmed E, Li B, Dou J, Qiao X, Jiang W, et al. Breast cancer metastasis suppressor 1 modulates SIRT1-dependent p53 deacetylation through interacting with DBC1. Am J Cancer Res. 2016;6:1441-9 pubmed

Hogg S, Newbold A, Vervoort S, Cluse L, Martin B, Gregory G, et al. BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members. Mol Cancer Ther. 2016;15:2030-41 pubmed publisher

Zea A, Stewart T, Ascani J, Tate D, Finkel Jimenez B, Wilk A, et al. Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?. PLoS ONE. 2016;11:e0157907 pubmed publisher

Chen Z, Wang Z, Pang J, Yu Y, Bieerkehazhi S, Lu J, et al. Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep. 2016;6:29090 pubmed publisher

Badal S, Wang Y, Long J, Corcoran D, CHANG B, Truong L, et al. miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. Nat Commun. 2016;7:12076 pubmed publisher

Borowiec A, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, et al. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. FASEB J. 2016;30:3155-70 pubmed publisher

Wagner S, Satpathy S, Beli P, Choudhary C. SPATA2 links CYLD to the TNF-? receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016;35:1868-84 pubmed publisher

Andersson A, Andersson B, Lorell C, Raffetseder J, Larsson M, Blomgran R. Autophagy induction targeting mTORC1 enhances Mycobacterium tuberculosis replication in HIV co-infected human macrophages. Sci Rep. 2016;6:28171 pubmed publisher

Kargaran P, Yasaei H, Anjomani Virmouni S, Mangiapane G, Slijepcevic P. Analysis of alternative lengthening of telomere markers in BRCA1 defective cells. Genes Chromosomes Cancer. 2016;55:864-76 pubmed publisher

Minakawa Y, Atsumi Y, Shinohara A, Murakami Y, Yoshioka K. Gamma-irradiated quiescent cells repair directly induced double-strand breaks but accumulate persistent double-strand breaks during subsequent DNA replication. Genes Cells. 2016;21:789-97 pubmed publisher

Heise C, Schroeder J, Schoen M, Halbedl S, Reim D, Woelfle S, et al. Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus. Front Cell Neurosci. 2016;10:106 pubmed publisher

de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J, et al. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016;7:11551 pubmed publisher

Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs S, Diehl J. miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016;7:11422 pubmed publisher

Teo W, Merino V, Cho S, Korangath P, Liang X, Wu R, et al. HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24. Oncogene. 2016;35:5539-5551 pubmed publisher

Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, et al. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Nat Commun. 2016;7:11379 pubmed publisher

Rapiteanu R, Davis L, Williamson J, Timms R, Paul Luzio J, Lehner P. A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin. Traffic. 2016;17:940-58 pubmed publisher

Tenorio M, Ross B, Luchsinger C, Rivera Dictter A, Arriagada C, Acuña D, et al. Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. PLoS ONE. 2016;11:e0154719 pubmed publisher

Strappazzon F, Di Rita A, Cianfanelli V, D Orazio M, Nazio F, Fimia G, et al. Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. Autophagy. 2016;12:963-75 pubmed publisher

Matias A, Manieri T, Cerchiaro G. Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation. Oxid Med Cell Longev. 2016;2016:6724585 pubmed publisher

Thakkar A, Wang B, Picon Ruiz M, Buchwald P, Ince T. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast Cancer Res Treat. 2016;157:77-90 pubmed publisher

Xue Y, Qian H, Hu J, Zhou B, Zhou Y, Hu X, et al. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nat Neurosci. 2016;19:807-15 pubmed publisher

Ren H, Elgner F, Jiang B, Himmelsbach K, Medvedev R, Ploen D, et al. The Autophagosomal SNARE Protein Syntaxin 17 Is an Essential Factor for the Hepatitis C Virus Life Cycle. J Virol. 2016;90:5989-6000 pubmed publisher

Wohlgemuth S, Ramirez Lee Y, Tao S, Monteiro A, Ahmed B, Dahl G. Short communication: Effect of heat stress on markers of autophagy in the mammary gland during the dry period. J Dairy Sci. 2016;99:4875-4880 pubmed publisher

Huang Y, Amin A, Qin Y, Wang Z, Jiang H, Liang L, et al. A Role of hIPI3 in DNA Replication Licensing in Human Cells. PLoS ONE. 2016;11:e0151803 pubmed publisher

Katlinskaya Y, Katlinski K, Yu Q, Ortiz A, Beiting D, Brice A, et al. Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Rep. 2016;15:171-180 pubmed publisher

West A, Martin B, Andrews D, Hogg S, Banerjee A, Grigoriadis G, et al. The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock. Oncogenesis. 2016;5:e216 pubmed publisher

Nemeth T, Futosi K, Sitaru C, Ruland J, Mocsai A. Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo. Nat Commun. 2016;7:11004 pubmed publisher

Wiechens N, Singh V, Gkikopoulos T, Schofield P, Rocha S, Owen Hughes T. The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors. PLoS Genet. 2016;12:e1005940 pubmed publisher

Vermeer D, Coppock J, Zeng E, Lee K, Spanos W, Onken M, et al. Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. Oncotarget. 2016;7:24194-207 pubmed publisher

Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, et al. Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells. Cancer Sci. 2016;107:734-45 pubmed publisher

Shih Y, Hsueh Y. VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation. Nat Commun. 2016;7:11020 pubmed publisher

Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, et al. Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice. Arthritis Res Ther. 2016;18:62 pubmed publisher

Pandiri I, Chen Y, Joe Y, Kim H, Park J, Chung H, et al. Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells. Breast Cancer Res Treat. 2016;156:57-64 pubmed publisher

Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle. 2016;6:5 pubmed publisher

Pokharel D, Padula M, Lu J, Jaiswal R, Djordjevic S, Bebawy M. The Role of CD44 and ERM Proteins in Expression and Functionality of P-glycoprotein in Breast Cancer Cells. Molecules. 2016;21:290 pubmed publisher

Karuppagounder S, Alim I, Khim S, Bourassa M, Sleiman S, John R, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016;8:328ra29 pubmed publisher

De Herdt M, Willems S, van der Steen B, Noorlag R, Verhoef E, van Leenders G, et al. Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma. Oncotarget. 2016;7:13167-81 pubmed publisher

Edalat L, Stegen B, Klumpp L, Haehl E, Schilbach K, Lukowski R, et al. BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells. Oncotarget. 2016;7:14259-78 pubmed publisher

del Río C, Navarrete C, Collado J, Bellido M, Gómez Cañas M, Pazos M, et al. The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways. Sci Rep. 2016;6:21703 pubmed publisher

Lee M, Goralczyk A, Kriszt R, Ang X, Badowski C, Li Y, et al. ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs. Sci Rep. 2016;6:21173 pubmed publisher

Zhu Y, Gao W, Zhang Y, Jia F, Zhang H, Liu Y, et al. Astrocyte-derived phosphatidic acid promotes dendritic branching. Sci Rep. 2016;6:21096 pubmed publisher

Trivedi P, Bruns T, Ward S, Mai M, Schmidt C, Hirschfield G, et al. Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity. J Autoimmun. 2016;68:98-104 pubmed publisher

Anjum S, Krishna A, Tsutsui K. Possible Role of GnIH as a Mediator between Adiposity and Impaired Testicular Function. Front Endocrinol (Lausanne). 2016;7:6 pubmed publisher

Oh S, Onomoto K, Wakimoto M, Onoguchi K, Ishidate F, Fujiwara T, et al. Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules. PLoS Pathog. 2016;12:e1005444 pubmed publisher

Klumpp D, Misovic M, Szteyn K, Shumilina E, Rudner J, Huber S. Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent Manner. Oxid Med Cell Longev. 2016;2016:8026702 pubmed publisher

Hayashi H, Al Mamun A, Sakima M, Sato M. Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis. J Cell Sci. 2016;129:1210-22 pubmed publisher

Krick S, Wang J, St Pierre M, Gonzalez C, Dahl G, Salathe M. Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production. J Biol Chem. 2016;291:6423-32 pubmed publisher

Li Y, Lu W, Saini S, Moukha Chafiq O, Pathak V, Ananthan S. Identification of quinazoline compounds as novel potent inhibitors of Wnt/?-catenin signaling in colorectal cancer cells. Oncotarget. 2016;7:11263-70 pubmed publisher

Lee Kubli C, Ingves M, Henry K, Shiao R, Collyer E, Tuszynski M, et al. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016;278:91-104 pubmed publisher

Couderc C, Boin A, Fuhrmann L, Vincent Salomon A, Mandati V, Kieffer Y, et al. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. Neoplasia. 2016;18:10-24 pubmed publisher

Khoory J, Estanislau J, Elkhal A, Lazaar A, Melhorn M, Brodsky A, et al. Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function. PLoS ONE. 2016;11:e0141206 pubmed publisher

Vlčková K, Ondrušová L, Vachtenheim J, Réda J, Dundr P, Zadinová M, et al. Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells. Cell Death Dis. 2016;7:e2048 pubmed publisher

Vais H, Mallilankaraman K, Mak D, Hoff H, Payne R, Tanis J, et al. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep. 2016;14:403-410 pubmed publisher

Visavadiya N, Patel S, VanRooyen J, Sullivan P, Rabchevsky A. Cellular and subcellular oxidative stress parameters following severe spinal cord injury. Redox Biol. 2016;8:59-67 pubmed publisher

Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, et al. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. Sci Rep. 2016;6:19174 pubmed publisher

Klawitter S, Fuchs N, Upton K, Muñoz Lopez M, Shukla R, Wang J, et al. Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nat Commun. 2016;7:10286 pubmed publisher

Baude A, Aaes T, Zhai B, Al Nakouzi N, Oo H, Daugaard M, et al. Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. Nucleic Acids Res. 2016;44:2214-26 pubmed publisher

Toledo R, Qin Y, Cheng Z, Gao Q, Iwata S, Silva G, et al. Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clin Cancer Res. 2016;22:2301-10 pubmed publisher

Liu Z, Oyola M, Zhou S, Chen X, Liao L, Tien J, et al. Knockout of the Histone Demethylase Kdm3b Decreases Spermatogenesis and Impairs Male Sexual Behaviors. Int J Biol Sci. 2015;11:1447-57 pubmed publisher

Brunati M, Perucca S, Han L, Cattaneo A, Consolato F, Andolfo A, et al. The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. elife. 2015;4:e08887 pubmed publisher

Mills K, Brocardo M, Henderson B. APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. Mol Biol Cell. 2016;27:466-82 pubmed publisher

Weijer R, Broekgaarden M, Krekorian M, Alles L, van Wijk A, Mackaaij C, et al. Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy. Oncotarget. 2016;7:3341-56 pubmed publisher

Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, et al. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol. 2016;18:202-12 pubmed publisher

Kaizuka T, Mizushima N. Atg13 Is Essential for Autophagy and Cardiac Development in Mice. Mol Cell Biol. 2016;36:585-95 pubmed publisher

Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol. 2016;17:250-8 pubmed publisher

Mani M, Lee U, Yoon N, Kim H, Ko M, Seol W, et al. Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling. Mol Biol Cell. 2016;27:334-48 pubmed publisher

Yi Y, Cai L, Shao Y, Xu M, Yi J. The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Int J Ophthalmol. 2015;8:884-90 pubmed publisher

Dixon D, Coates J, Del Carpio Pons A, Horabin J, Walker A, Abdul N, et al. A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty. Sci Rep. 2015;5:16466 pubmed publisher

Elgner F, Donnerhak C, Ren H, Medvedev R, Schreiber A, Weber L, et al. Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus. Biochem J. 2016;473:145-55 pubmed publisher

Liu C, Zheng L, Wang H, Ran X, Liu H, Sun X. The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice. Cell Death Dis. 2015;6:e1929 pubmed publisher

Kenney J, Genheden M, Moon K, Wang X, Foster L, Proud C. Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons. J Neurochem. 2016;136:276-84 pubmed publisher

Okoye Okafor U, Bartholdy B, Cartier J, Gao E, Pietrak B, Rendina A, et al. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat Chem Biol. 2015;11:878-86 pubmed publisher

Adesina A, Veo B, Courteau G, Mehta V, Wu X, Pang K, et al. FOXG1 expression shows correlation with neuronal differentiation in cerebellar development, aggressive phenotype in medulloblastomas, and survival in a xenograft model of medulloblastoma. Hum Pathol. 2015;46:1859-71 pubmed publisher

Zoppi N, Chiarelli N, Cinquina V, Ritelli M, Colombi M. GLUT10 deficiency leads to oxidative stress and non-canonical αvβ3 integrin-mediated TGFβ signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts. Hum Mol Genet. 2015;24:6769-87 pubmed publisher

Laird J, Pan Y, Modestou M, Yamaguchi D, Song H, Sokolov M, et al. Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase. Traffic. 2015;16:1239-53 pubmed publisher

Bohovych I, Fernandez M, Rahn J, Stackley K, Bestman J, Anandhan A, et al. Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability. Sci Rep. 2015;5:13989 pubmed publisher

Cavieres V, González A, Muñoz V, Yefi C, Bustamante H, Barraza R, et al. Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy. PLoS ONE. 2015;10:e0136313 pubmed publisher

Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed publisher

Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher

Zhang Z, Wang Y, Yan S, Du F, Yan S. NR2B-dependent cyclophilin D translocation suppresses the recovery of synaptic transmission after oxygen-glucose deprivation. Biochim Biophys Acta. 2015;1852:2225-2234 pubmed publisher

Quintana M, He J, Sullivan J, Grevengoed T, Schisler J, Han Y, et al. Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. BMC Endocr Disord. 2015;15:36 pubmed publisher

Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed publisher

Lin A, Abbas S, Kim S, Ortega M, Bouamar H, Escobedo Y, et al. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Nat Commun. 2015;6:7768 pubmed publisher

Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049-61 pubmed publisher

Pulito C, Mori F, Sacconi A, Casadei L, Ferraiuolo M, Valerio M, et al. Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion. Oncotarget. 2015;6:18134-50 pubmed

Sano M, Hashiba K, Higashi M, Okuda K. Alteration of glycan structures by swainsonine affects steroidogenesis in bovine luteal cells. Theriogenology. 2015;84:827-32 pubmed publisher

Sáez J, Gómez A, Barrios Ã, Parada G, Galdames L, González M, et al. Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation. PLoS ONE. 2015;10:e0131760 pubmed publisher

Chhabra S, Jain S, Wallace C, Hong F, Liu B. High expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myeloma. J Hematol Oncol. 2015;8:77 pubmed publisher

Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed publisher

Khan K, Dô F, Marineau A, Doyon P, Clément J, Woodgett J, et al. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. Mol Cell Biol. 2015;35:3029-43 pubmed publisher

Bonfim Melo A, Zanetti B, Ferreira Ã, Vandoninck S, Han S, Van Lint J, et al. Trypanosoma cruzi extracellular amastigotes trigger the protein kinase D1-cortactin-actin pathway during cell invasion. Cell Microbiol. 2015;17:1797-810 pubmed publisher

Lundvig D, Pennings S, Brouwer K, Mtaya Mlangwa M, Mugonzibwa E, Kuijpers Jagtman A, et al. Cytoprotective responses in HaCaT keratinocytes exposed to high doses of curcumin. Exp Cell Res. 2015;336:298-307 pubmed publisher

Hollingworth R, Skalka G, Stewart G, Hislop A, Blackbourn D, Grand R. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses. 2015;7:2908-27 pubmed publisher

Ching J, Amiridis S, Stylli S, Bjorksten A, Kountouri N, Zheng T, et al. The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells. Oncotarget. 2015;6:21301-14 pubmed

Andrade L. Evidence for changes in beta- and gamma-actin proportions during inner ear hair cell life. Cytoskeleton (Hoboken). 2015;72:282-91 pubmed publisher

Barber A, Castillo Martin M, Bonal D, Jia A, Rybicki B, Christiano A, et al. PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer. Cancer Med. 2015;4:1258-71 pubmed publisher

Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nat Commun. 2015;6:7250 pubmed publisher

Sato M, Matsubara T, Adachi J, Hashimoto Y, Fukamizu K, Kishida M, et al. Differential Proteome Analysis Identifies TGF-β-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model. PLoS ONE. 2015;10:e0126483 pubmed publisher

Yang C, Chiang C, Chen C, Lee Y, Wu M, Tsou Y, et al. Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58). J Biomed Sci. 2015;22:33 pubmed publisher

Bowdridge E, Goravanahally M, Inskeep E, Flores J. Activation of Adenosine Monophosphate-Activated Protein Kinase Is an Additional Mechanism That Participates in Mediating Inhibitory Actions of Prostaglandin F2Alpha in Mature, but Not Developing, Bovine Corpora Lutea. Biol Reprod. 2015;93:7 pubmed publisher

Scala F, Brighenti E, Govoni M, Imbrogno E, Fornari F, Treré D, et al. Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. Oncogene. 2016;35:977-89 pubmed publisher

Studzian M, Bartosz G, Pulaski L. Endocytosis of ABCG2 drug transporter caused by binding of 5D3 antibody: trafficking mechanisms and intracellular fate. Biochim Biophys Acta. 2015;1853:1759-71 pubmed publisher

Lin Y, Yuan J, Pei H, Liu T, Ann D, Lou Z. KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair. PLoS ONE. 2015;10:e0123935 pubmed publisher

Cattoglio C, Zhang E, Grubisic I, Chiba K, Fong Y, Tjian R. Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proc Natl Acad Sci U S A. 2015;112:E2317-26 pubmed publisher

Ho F, Zhang W, Li Y, Chan B. Mechanoresponsive, omni-directional and local matrix-degrading actin protrusions in human mesenchymal stem cells microencapsulated in a 3D collagen matrix. Biomaterials. 2015;53:392-405 pubmed publisher

Erkelenz S, Hillebrand F, Widera M, Theiss S, Fayyaz A, Degrandi D, et al. Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication. Retrovirology. 2015;12:29 pubmed publisher

Roca Rodríguez M, El Bekay R, Garrido Sanchez L, Gómez Serrano M, Coin Aragüez L, Oliva Olivera W, et al. Parathyroid Hormone-Related Protein, Human Adipose-Derived Stem Cells Adipogenic Capacity and Healthy Obesity. J Clin Endocrinol Metab. 2015;100:E826-35 pubmed publisher

Zarzycka M, Chojnacka K, Mruk D, Górowska E, Hejmej A, Kotula Balak M, et al. Flutamide alters the distribution of c-Src and affects the N-cadherin-β-catenin complex in the seminiferous epithelium of adult rat. Andrology. 2015;3:569-81 pubmed publisher

Jühlen R, Idkowiak J, Taylor A, Kind B, Arlt W, Huebner A, et al. Role of ALADIN in human adrenocortical cells for oxidative stress response and steroidogenesis. PLoS ONE. 2015;10:e0124582 pubmed publisher

Kropp K, Hsieh W, Isern E, Forster T, Krause E, Brune W, et al. A temporal gate for viral enhancers to co-opt Toll-like-receptor transcriptional activation pathways upon acute infection. PLoS Pathog. 2015;11:e1004737 pubmed publisher

Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed publisher

Sand C, Grant A, Nandi M. Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1). J Histochem Cytochem. 2015;63:449-53 pubmed publisher

Chu V, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, et al. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol. 2015;33:543-8 pubmed publisher

Rigalli J, Ciriaci N, Arias A, Ceballos M, Villanueva S, Luquita M, et al. Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity. PLoS ONE. 2015;10:e0119502 pubmed publisher

Honegger A, Schilling D, Bastian S, Sponagel J, Kuryshev V, Sultmann H, et al. Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog. 2015;11:e1004712 pubmed publisher

Shibayama Y, Kondo T, Ohya H, Fujisawa S, Teshima T, Iseki K. Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients. Oncol Rep. 2015;33:2176-82 pubmed publisher

Aubrey B, Kelly G, Kueh A, Brennan M, O Connor L, Milla L, et al. An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo. Cell Rep. 2015;10:1422-32 pubmed publisher

Bulk E, Ay A, Hammadi M, Ouadid Ahidouch H, Schelhaas S, Hascher A, et al. Epigenetic dysregulation of KCa 3.1 channels induces poor prognosis in lung cancer. Int J Cancer. 2015;137:1306-17 pubmed publisher

Perrigue P, Silva M, Warden C, Feng N, Reid M, Mota D, et al. The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines. Mol Cancer Res. 2015;13:636-50 pubmed publisher

Michelet X, Garg S, Wolf B, Tuli A, Ricciardi Castagnoli P, Brenner M. MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b. J Immunol. 2015;194:2079-88 pubmed publisher

Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu Kaoud N, Halabi N, et al. Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. J Transl Med. 2015;13:27 pubmed publisher

Hsiao S, Chen M, Chen C, Chien M, Hua K, Hsiao M, et al. The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer. Ann Surg Oncol. 2015;22 Suppl 3:S1556-65 pubmed publisher

La Sala G, Marazziti D, Di Pietro C, Golini E, Matteoni R, Tocchini Valentini G. Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015;29:2059-69 pubmed publisher

Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, et al. SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Oncotarget. 2015;6:771-88 pubmed

Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M. Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface. J Biol Chem. 2015;290:7027-39 pubmed publisher

Lubas M, Andersen P, Schein A, Dziembowski A, Kudla G, Jensen T. The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis. Cell Rep. 2015;10:178-92 pubmed publisher

Fitzgerald P, Pinard C, Camp M, Feyder M, Sah A, Bergstrom H, et al. Durable fear memories require PSD-95. Mol Psychiatry. 2015;20:901-12 pubmed publisher

Ventelä S, Sittig E, Mannermaa L, Mäkelä J, Kulmala J, Löyttyniemi E, et al. CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance. Oncotarget. 2015;6:144-58 pubmed

Lu S, Zeumer L, Sorensen H, Yang H, Ng Y, Yu F, et al. The murine Pbx1-d lupus susceptibility allele accelerates mesenchymal stem cell differentiation and impairs their immunosuppressive function. J Immunol. 2015;194:43-55 pubmed

Huang L, Carney J, Cardona D, Counter C. Decreased tumorigenesis in mice with a Kras point mutation at C118. Nat Commun. 2014;5:5410 pubmed publisher

Grau C, Arató K, Fernández Fernández J, Valderrama A, Sindreu C, Fillat C, et al. DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors. Front Cell Neurosci. 2014;8:331 pubmed publisher

Martin S, Lovat P, Redfern C. Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells. J Cell Biochem. 2015;116:438-49 pubmed publisher

Wang D, Zhang P, Gao K, Tang Y, Jin X, Zhang Y, et al. PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. PLoS ONE. 2014;9:e110296 pubmed publisher

Holland W, Chinn D, Lara P, Gandara D, Mack P. Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines. J Cancer Res Clin Oncol. 2015;141:615-26 pubmed publisher

Ortega M, Bhatnagar H, Lin A, Wang L, Aster J, Sill H, et al. A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies. Leukemia. 2015;29:968-76 pubmed publisher

Candelaria N, Addanki S, Zheng J, Nguyen Vu T, Karaboga H, Dey P, et al. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. PLoS ONE. 2014;9:e106289 pubmed publisher

Kambara H, Niazi F, Kostadinova L, Moonka D, Siegel C, Post A, et al. Negative regulation of the interferon response by an interferon-induced long non-coding RNA. Nucleic Acids Res. 2014;42:10668-80 pubmed publisher

George S, Vishwamitra D, Manshouri R, Shi P, Amin H. The ALK inhibitor ASP3026 eradicates NPM-ALK? T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget. 2014;5:5750-63 pubmed

Cui Y, Xu H, Wu H, Qi J, Shi J, Li Y. Spatio-temporal expression and functional involvement of transient receptor potential vanilloid 1 in diabetic mechanical allodynia in rats. PLoS ONE. 2014;9:e102052 pubmed publisher

Baraz R, Cisterne A, Saunders P, Hewson J, Thien M, Weiss J, et al. mTOR inhibition by everolimus in childhood acute lymphoblastic leukemia induces caspase-independent cell death. PLoS ONE. 2014;9:e102494 pubmed publisher

Kehoe L, Bellone C, De Roo M, Zandueta A, Dey P, Pérez Otaño I, et al. GluN3A promotes dendritic spine pruning and destabilization during postnatal development. J Neurosci. 2014;34:9213-21 pubmed publisher

Zhang P, Gao K, Tang Y, Jin X, An J, Yu H, et al. Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants. Hum Mutat. 2014;35:1142-51 pubmed publisher

Gemel J, Simon A, Patel D, Xu Q, Matiukas A, Veenstra R, et al. Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated. J Mol Cell Cardiol. 2014;74:330-9 pubmed publisher

Girgis C, Mokbel N, Cha K, Houweling P, Abboud M, Fraser D, et al. The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology. 2014;155:3227-37 pubmed publisher

Wilmes A, Aschauer L, Limonciel A, Pfaller W, Jennings P. Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014;279:163-72 pubmed publisher

Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey M, Kuum M, et al. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy. 2014;10:1105-19 pubmed publisher

Suh H, Lo Y, Choi N, Letendre S, Lee S. Evidence of the innate antiviral and neuroprotective properties of progranulin. PLoS ONE. 2014;9:e98184 pubmed publisher

Dichamp I, Seite P, Agius G, Barbarin A, Beby Defaux A. Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF. PLoS ONE. 2014;9:e96136 pubmed publisher

Gürtler C, Carty M, Kearney J, Schattgen S, Ding A, Fitzgerald K, et al. SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter. J Immunol. 2014;192:4821-32 pubmed publisher

Jung Y, Vermeer P, Vermeer D, Lee S, Goh A, Ahn H, et al. CD200: association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma. Head Neck. 2015;37:327-35 pubmed publisher

Termini C, Cotter M, Marjon K, Buranda T, Lidke K, Gillette J. The membrane scaffold CD82 regulates cell adhesion by altering α4 integrin stability and molecular density. Mol Biol Cell. 2014;25:1560-73 pubmed publisher

Cheng J, Fan Y, Xu X, Dou J, Tang Y, Zhong X, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5:e1079 pubmed publisher

Bots M, Verbrugge I, Martin B, Salmon J, Ghisi M, Baker A, et al. Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. 2014;123:1341-52 pubmed publisher

Andresen C, Smedegaard S, Sylvestersen K, Svensson C, Iglesias Gato D, Cazzamali G, et al. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. J Biol Chem. 2014;289:2043-54 pubmed publisher

Molina Vila M, Nabau Moretó N, Tornador C, Sabnis A, Rosell R, Estivill X, et al. Activating mutations cluster in the "molecular brake" regions of protein kinases and do not associate with conserved or catalytic residues. Hum Mutat. 2014;35:318-28 pubmed publisher

Ngamsiri P, Watcharasit P, Satayavivad J. Glycogen synthase kinase-3 (GSK3) controls deoxyglucose-induced mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells. Mitochondrion. 2014;14:54-63 pubmed publisher

Jesus P, Ouelaa W, François M, Riachy L, Guérin C, Aziz M, et al. Alteration of intestinal barrier function during activity-based anorexia in mice. Clin Nutr. 2014;33:1046-53 pubmed publisher

Whiteman E, Fan S, Harder J, Walton K, Liu C, Soofi A, et al. Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014;34:43-56 pubmed publisher

Heydendael W, Sengupta A, Beck S, Bhatnagar S. Optogenetic examination identifies a context-specific role for orexins/hypocretins in anxiety-related behavior. Physiol Behav. 2014;130:182-90 pubmed publisher

Fernandez S, Genis L, Torres Aleman I. A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-1 loop. Oncogene. 2014;33:4114-22 pubmed publisher

Whittington R, Bretteville A, Virag L, Emala C, Maurin T, Marcouiller F, et al. Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation. Sci Rep. 2013;3:1388 pubmed publisher

Jia B, Choy E, Cote G, Harmon D, Ye S, Kan Q, et al. Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells. Cancer Lett. 2014;342:104-12 pubmed publisher

Yoshida R, Nagata M, Nakayama H, Niimori Kita K, Hassan W, Tanaka T, et al. The pathological significance of Notch1 in oral squamous cell carcinoma. Lab Invest. 2013;93:1068-81 pubmed publisher

Brochier C, Dennis G, Rivieccio M, McLaughlin K, Coppola G, Ratan R, et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci. 2013;33:8621-32 pubmed publisher

Hakucho A, Liu J, Liu X, Fujimiya T. Carvedilol improves ethanol-induced liver injury via modifying the interaction between oxidative stress and sympathetic hyperactivity in rats. Hepatol Res. 2014;44:560-70 pubmed publisher

Huebbers C, Preuss S, Kolligs J, Vent J, Stenner M, Wieland U, et al. Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis. PLoS ONE. 2013;8:e57207 pubmed publisher

Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, et al. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance. PLoS ONE. 2013;8:e55361 pubmed publisher

Forand A, Beck L, Leroy C, Rousseau A, Boitez V, Cohen I, et al. EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro. Blood. 2013;121:666-78 pubmed publisher

Kenneth N, Younger J, Hughes E, Marcotte D, Barker P, Saunders T, et al. An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J. 2012;443:355-9 pubmed publisher

Ewald F, Ueffing N, Brockmann L, Hader C, Telieps T, Schuster M, et al. The role of c-FLIP splice variants in urothelial tumours. Cell Death Dis. 2011;2:e245 pubmed publisher

Xin Y, Lu Q, Li Q. IKK1 control of epidermal differentiation is modulated by notch signaling. Am J Pathol. 2011;178:1568-77 pubmed publisher

Bloch J, Kaeser M, Sadeghi Y, Rouiller E, Redmond D, Brunet J. Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development. J Comp Neurol. 2011;519:775-89 pubmed publisher

Foster C, Dovey O, Lezina L, Luo J, Gant T, Barlev N, et al. Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol. 2010;30:4851-63 pubmed publisher

Roblek M, Schüchner S, Huber V, Ollram K, Vlcek Vesely S, Foisner R, et al. Monoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482W. PLoS ONE. 2010;5:e10604 pubmed publisher

Garver W, Jelinek D, Francis G, Murphy B. The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts. J Lipid Res. 2008;49:1090-102 pubmed publisher

Lagger G, Doetzlhofer A, Schuettengruber B, Haidweger E, Simboeck E, Tischler J, et al. The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol. 2003;23:2669-79 pubmed

Kapralov A, Yang Q, Dar H, Tyurina Y, Anthonymuthu T, Kim R, et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16:278-290 pubmed publisher

Meng J, Liu K, Shao Y, Feng X, Ji Z, Chang B, et al. ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy. Cell Death Dis. 2020;11:137 pubmed publisher

Zhao N, Attrebi O, Ren Y, Qiao W, Sonustun B, Martens Y, et al. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Sci Transl Med. 2020;12: pubmed publisher

Rastogi S, Haldar C. Role of melatonin and HSF-1\HSP-70 in modulating cold stress-induced immunosuppression in a tropical rodent- Funambulus pennanti. J Therm Biol. 2020;87:102456 pubmed publisher

Tseng V, Ni K, Allawzi A, Prohaska C, Hernandez Lagunas L, Elajaili H, et al. Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension. Sci Rep. 2020;10:280 pubmed publisher

Xiao K, Liu C, Qin Q, Zhang Y, Wang X, Zhang J, et al. EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway. FASEB J. 2020;34:2483-2496 pubmed publisher

Xing X, Wu K, Dong Y, Zhou Y, Zhang J, Jiang F, et al. Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice. Neuropharmacology. 2020;165:107816 pubmed publisher

Kunitomi C, Harada M, Takahashi N, Azhary J, Kusamoto A, Nose E, et al. Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma. Mol Hum Reprod. 2020;26:40-52 pubmed publisher

Verdura E, Schluter A, Fernández Eulate G, Ramos Martín R, Zulaica M, Planas Serra L, et al. A deep intronic splice variant advises reexamination of presumably dominant SPG7 Cases. Ann Clin Transl Neurol. 2020;7:105-111 pubmed publisher

Kumari S, Khan S, Sekhri R, Mandil H, Behrman S, Yallapu M, et al. Protein kinase D1 regulates metabolic switch in pancreatic cancer via modulation of mTORC1. Br J Cancer. 2020;122:121-131 pubmed publisher

Hertlein V, Flores Romero H, Das K, Fischer S, Heunemann M, Calleja Felipe M, et al. MERLIN: a novel BRET-based proximity biosensor for studying mitochondria-ER contact sites. Life Sci Alliance. 2020;3: pubmed publisher

Jonus H, Byrnes C, Kim J, Valle M, Bartlett M, Said H, et al. Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy. Biomed Pharmacother. 2020;121:109648 pubmed publisher

Aguilar C, Cruz A, Rodrigues Lopes I, Maudet C, Sunkavalli U, Silva R, et al. Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection. Nat Microbiol. 2020;5:192-205 pubmed publisher

Egusquiaguirre S, Liu S, Tošić I, Jiang K, Walker S, Nicolais M, et al. CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3. Neoplasia. 2020;22:47-59 pubmed publisher

Mahesh A, Khan M, Govindaraju G, Verma M, Awasthi S, Chavali P, et al. SET7/9 interacts and methylates the ribosomal protein, eL42 and regulates protein synthesis. Biochim Biophys Acta Mol Cell Res. 2020;1867:118611 pubmed publisher

Kim D, Dollé M, Vermeij W, Gyenis A, Vogel K, Hoeijmakers J, et al. Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Aging Cell. 2020;19:e13072 pubmed publisher

Rahimizadeh P, Topraggaleh T, Nasr Esfahani M, Ziarati N, Mirshahvaladi S, Esmaeili V, et al. The alteration of PLCζ protein expression in unexplained infertile and asthenoteratozoospermic patients: A potential effect on sperm fertilization ability. Mol Reprod Dev. 2020;87:115-123 pubmed publisher

. Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism. Mol Pharmacol. 2020;97:9-22 pubmed publisher

Wang L, Sparacino Watkins C, Wang J, Wajih N, Varano P, Xu Q, et al. Carbonic anhydrase II does not regulate nitrite-dependent nitric oxide formation and vasodilation. Br J Pharmacol. 2020;177:898-911 pubmed publisher

Kawagishi T, Nurdin J, Onishi M, Nouda R, Kanai Y, Tajima T, et al. Reverse Genetics System for a Human Group A Rotavirus. J Virol. 2020;94: pubmed publisher

Limboonreung T, Tuchinda P, Chongthammakun S. Chrysoeriol mediates mitochondrial protection via PI3K/Akt pathway in MPP+ treated SH-SY5Y cells. Neurosci Lett. 2020;714:134545 pubmed publisher

Braun J, Herrmann A, Blase J, Frensemeier K, Bulkescher J, Scheffner M, et al. Effects of the antifungal agent ciclopirox in HPV-positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis. Int J Cancer. 2020;146:461-474 pubmed publisher

Ciołczyk Wierzbicka D, Gil D, Zarzycka M, Laidler P. mTOR inhibitor everolimus reduces invasiveness of melanoma cells. Hum Cell. 2020;33:88-97 pubmed publisher

Fernandez Castaneda A, Chappell M, Rosen D, Seki S, Beiter R, Johanson D, et al. The active contribution of OPCs to neuroinflammation is mediated by LRP1. Acta Neuropathol. 2020;139:365-382 pubmed publisher

Trudler D, Levy Barazany H, Nash Y, Samuel L, Sharon R, Frenkel D. Alpha synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner. J Neurochem. 2020;152:61-71 pubmed publisher

Inwood S, Abaandou L, Betenbaugh M, Shiloach J. Improved protein expression in HEK293 cells by over-expressing miR-22 and knocking-out its target gene, HIPK1. N Biotechnol. 2020;54:28-33 pubmed publisher

Manek R, Nelson T, Tseng E, Rodriguez Lebron E. 5'UTR-mediated regulation of Ataxin-1 expression. Neurobiol Dis. 2020;134:104564 pubmed publisher

Goodson Gregg F, Rothbard B, Zhang A, Wright P, Li H, Walker Sperling V, et al. Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing. Front Immunol. 2019;10:3034 pubmed publisher

Palhinha L, Liechocki S, Hottz E, Pereira J, de Almeida C, Moraes Vieira P, et al. Leptin Induces Proadipogenic and Proinflammatory Signaling in Adipocytes. Front Endocrinol (Lausanne). 2019;10:841 pubmed publisher

Vajente N, Norante R, Redolfi N, Daga A, Pizzo P, Pendin D. Microtubules Stabilization by Mutant Spastin Affects ER Morphology and Ca2+ Handling. Front Physiol. 2019;10:1544 pubmed publisher

Nitta K, Nishinaka A, Hida Y, Nakamura S, Shimazawa M, Hara H. Oral and ocular administration of crocetin prevents retinal edema in a murine retinal vein occlusion model. Mol Vis. 2019;25:859-868 pubmed

Venturini A, Passalacqua M, Pelassa S, Pastorino F, Tedesco M, Cortese K, et al. Exosomes From Astrocyte Processes: Signaling to Neurons. Front Pharmacol. 2019;10:1452 pubmed publisher

Akin R, Hannibal D, Loida M, Stevens E, Grunz Borgmann E, Parrish A. Cadmium and Lead Decrease Cell-Cell Aggregation and Increase Migration and Invasion in Renca Mouse Renal Cell Carcinoma Cells. Int J Mol Sci. 2019;20: pubmed publisher

Nasrullah U, Haeussler K, Biyanee A, Wittig I, Pfeilschifter J, Eberhardt W. Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis. Cells. 2019;8: pubmed publisher

Avalos de León C, Jiménez Castro M, Cornide Petronio M, Casillas Ramirez A, Peralta C. The Role of GLP1 in Rat Steatotic and Non-Steatotic Liver Transplantation from Cardiocirculatory Death Donors. Cells. 2019;8: pubmed publisher

Llorens M, Rossi F, García I, Cooke M, Abba M, Lopez Haber C, et al. PKCα Modulates Epithelial-to-Mesenchymal Transition and Invasiveness of Breast Cancer Cells Through ZEB1. Front Oncol. 2019;9:1323 pubmed publisher

Garrido M, Hurtado I, Valenzuela Valderrama M, Salvatierra R, Hernandez A, Vega M, et al. NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE2 Signaling Axis. Cancers (Basel). 2019;11: pubmed publisher

Ziegler Y, Laws M, Sanabria Guillen V, Kim S, Dey P, Smith B, et al. Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds. NPJ Breast Cancer. 2019;5:45 pubmed publisher

Kim S, Lee S, Lee E, Lim H, Shin J, Jung J, et al. Sex-biased differences in the correlation between epithelial-to-mesenchymal transition-associated genes in cancer cell lines. Oncol Lett. 2019;18:6852-6868 pubmed publisher

Lee C, Aizawa K, Jiang J, Kung S, Jain R. JLP-centrosome is essential for the microtubule-mediated nucleocytoplasmic transport induced by extracellular stimuli. Sci Adv. 2019;5:eaav0318 pubmed publisher

Green R, Howell M, Khalil R, Nair R, Yan J, Foran E, et al. Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway. Sci Rep. 2019;9:18177 pubmed publisher

Mpilla G, Aboukameel A, Muqbil I, Kim S, Beydoun R, Philip P, et al. PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors. Cancers (Basel). 2019;11: pubmed publisher

Han Y, Park G, Bae M, Kim J, Jo W, Lee C. Hypoxia induces immunogenic cell death of cancer cells by enhancing the exposure of cell surface calreticulin in an endoplasmic reticulum stress-dependent manner. Oncol Lett. 2019;18:6269-6274 pubmed publisher

Liu S, Yuan D, Li Y, Qi Q, Guo B, Yang S, et al. Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma. Front Pharmacol. 2019;10:1316 pubmed publisher

Lajqi T, Lang G, Haas F, Williams D, Hudalla H, Bauer M, et al. Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ. Front Immunol. 2019;10:2492 pubmed publisher

Antunes K, Becker A, Franceschina C, de Freitas D, Lape I, da Cunha M, et al. Respiratory syncytial virus reduces STAT3 phosphorylation in human memory CD8 T cells stimulated with IL-21. Sci Rep. 2019;9:17766 pubmed publisher

Li Z, Chen B, Dong W, Kong M, Fan Z, Yu L, et al. MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription. Cell Death Dis. 2019;10:899 pubmed publisher

Shao J, Xu H, Wu X, Xu Y. Epigenetic activation of CTGF transcription by high glucose in renal tubular epithelial cells is mediated by myocardin-related transcription factor A. Cell Tissue Res. 2019;: pubmed publisher

Kim W, Zhao F, Wu R, Qin S, Nowsheen S, Huang J, et al. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Nat Commun. 2019;10:5304 pubmed publisher

Jonczyk A, Piotrowska Tomala K, Skarzynski D. Effects of prostaglandin F2α (PGF2α) on cell-death pathways in the bovine corpus luteum (CL). BMC Vet Res. 2019;15:416 pubmed publisher

Li Z, Chen B, Dong W, Kong M, Shao Y, Fan Z, et al. The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice. Front Cell Dev Biol. 2019;7:245 pubmed publisher

Starr C, Nyankerh C, Qi X, Hu Y, Gorbatyuk O, Sonenberg N, et al. Role of Translational Attenuation in Inherited Retinal Degeneration. Invest Ophthalmol Vis Sci. 2019;60:4849-4857 pubmed publisher

Puri R, Yerrathota S, Home T, Idowu J, Chakravarthi V, Ward C, et al. Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy. Dis Model Mech. 2019;12: pubmed publisher

Garland W, Comet I, Wu M, Radzisheuskaya A, Rib L, Vitting Seerup K, et al. A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell Rep. 2019;29:1800-1811.e6 pubmed publisher

Campbell G, To R, Spector S. TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function. MBio. 2019;10: pubmed publisher

Xue J, Yu Y, Zhang X, Zhang C, Zhao Y, Liu B, et al. Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll-Like Receptor 4 to Lipid Rafts. J Am Heart Assoc. 2019;8:e012885 pubmed publisher

Kim J, Park J, Kim K, Leem J, Park K. Melatonin Inhibits Transforming Growth Factor-β1-Induced Epithelial-Mesenchymal Transition in AML12 Hepatocytes. Biology (Basel). 2019;8: pubmed publisher

Heilmann E, Kimpel J, Geley S, Naschberger A, Urbiola C, Nolden T, et al. The Methyltransferase Region of Vesicular Stomatitis Virus L Polymerase Is a Target Site for Functional Intramolecular Insertion. Viruses. 2019;11: pubmed publisher

Rudzinska M, Mikula M, Arczewska K, Gajda E, Sabalińska S, Stepien T, et al. Transcription Factor Prospero Homeobox 1 (PROX1) as a Potential Angiogenic Regulator of Follicular Thyroid Cancer Dissemination. Int J Mol Sci. 2019;20: pubmed publisher

Ji Q, Wang X, Cai J, Du X, Sun H, Zhang N. MiR-22-3p Regulates Amyloid β Deposit in Mice Model of Alzheimer's Disease by Targeting Mitogen-activated Protein Kinase 14. Curr Neurovasc Res. 2019;16:473-480 pubmed publisher

Grimaldi G, Vagaska B, Ievglevskyi O, Kondratskaya E, Glover J, Matthews J. Loss of Tiparp Results in Aberrant Layering of the Cerebral Cortex. Eneuro. 2019;6: pubmed publisher

Chopyk D, Stuart J, Zimmerman M, Wen J, Gumber S, Suthar M, et al. Acetaminophen Intoxication Rapidly Induces Apoptosis of Intestinal Crypt Stem Cells and Enhances Intestinal Permeability. Hepatol Commun. 2019;3:1435-1449 pubmed publisher

Takeuchi H, Sasaki N, Yamaga S, Kuboniwa M, Matsusaki M, Amano A. Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1. PLoS Pathog. 2019;15:e1008124 pubmed publisher

Ma D, Huang Y, Song S. Inhibiting the HPV16 oncogene-mediated glycolysis sensitizes human cervical carcinoma cells to 5-fluorouracil. Onco Targets Ther. 2019;12:6711-6720 pubmed publisher

Li Z, Xia J, Fang M, Xu Y. Epigenetic regulation of lung cancer cell proliferation and migration by the chromatin remodeling protein BRG1. Oncogenesis. 2019;8:66 pubmed publisher

Lu Y, Lv F, Kong M, Chen X, Duan Y, Chen X, et al. A cAbl-MRTF-A Feedback Loop Contributes to Hepatic Stellate Cell Activation. Front Cell Dev Biol. 2019;7:243 pubmed publisher

Carrasco Pozo C, Tan K, Rodriguez T, Avery V. The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor. Int J Mol Sci. 2019;20: pubmed publisher

Jiang J, Srivastava S, Seim G, Pavlova N, King B, Zou L, et al. Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. J Biol Chem. 2019;294:18674-18684 pubmed publisher

Kim H, Lee B, Jeon J, Kim D, Kang S, Shim J, et al. Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres. Biomolecules. 2019;9: pubmed publisher

Jiao W, Ji J, Xu W, Bu W, Zheng Y, Ma A, et al. Distinct downstream signaling and the roles of VEGF and PlGF in high glucose-mediated injuries of human retinal endothelial cells in culture. Sci Rep. 2019;9:15339 pubmed publisher

Chiou J, Chang Y, Tsai H, Lin Y, Huang M, Yang C, et al. Follistatin-like Protein 1 Inhibits Lung Cancer Metastasis by Preventing Proteolytic Activation of Osteopontin. Cancer Res. 2019;79:6113-6125 pubmed publisher

Peng H, Chau V, Phetsang W, Sebastian R, Stone M, Datta S, et al. Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo. Mol Ther Methods Clin Dev. 2019;15:27-39 pubmed publisher

Kim C, Seedorf G, Abman S, Shepherd D. Heterogeneous response of endothelial cells to insulin-like growth factor 1 treatment is explained by spatially clustered sub-populations. Biol Open. 2019;8: pubmed publisher

Thaker Y, Raab M, Strebhardt K, Rudd C. GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity. Nat Commun. 2019;10:4804 pubmed publisher

Ritter A, Friemel A, Roth S, Kreis N, Hoock S, Safdar B, et al. Subcutaneous and Visceral Adipose-Derived Mesenchymal Stem Cells: Commonality and Diversity. Cells. 2019;8: pubmed publisher

Mao L, Liu L, Zhang T, Wu X, Zhang T, Xu Y. MKL1 mediates TGF-β-induced CTGF transcription to promote renal fibrosis. J Cell Physiol. 2019;: pubmed publisher

Shao J, Xu Y, Fang M. BRG1 deficiency in endothelial cells alleviates thioacetamide induced liver fibrosis in mice. Biochem Biophys Res Commun. 2019;: pubmed publisher

Chen D, Hou Z, Jiang D, Zheng M, Li G, Zhang Y, et al. GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus. Emerg Microbes Infect. 2019;8:1511-1523 pubmed publisher

Metcalf S, Dougherty S, Kruer T, Hasan N, Biyik Sit R, Reynolds L, et al. Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer. Clin Exp Metastasis. 2019;: pubmed publisher

Srikantan S, Deng Y, Cheng Z, Luo A, Qin Y, Gao Q, et al. The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner. Nat Commun. 2019;10:4720 pubmed publisher

Cai W, Dai X, Chen J, Zhao J, Xu M, Zhang L, et al. STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice. JCI Insight. 2019;4: pubmed publisher

Göppner C, Orozco I, Hoegg Beiler M, Soria A, Hübner C, Fernandes Rosa F, et al. Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism. Nat Commun. 2019;10:4678 pubmed publisher

Krauss J, Roper P, Ballard A, Shih C, Fitzpatrick J, Cassat J, et al. Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly. MBio. 2019;10: pubmed publisher

Yoshida T, Sopko N, Kates M, Liu X, Joice G, McConkey D, et al. Impact of spheroid culture on molecular and functional characteristics of bladder cancer cell lines. Oncol Lett. 2019;18:4923-4929 pubmed publisher

Kumari A, Srivastava S, Manne R, Sisodiya S, Santra M, Guchhait S, et al. C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules. Biochem Pharmacol. 2019;170:113663 pubmed publisher

Zheng L, Li H, Fu L, Liu S, Yan Q, Leng S. Blocking cellular N-glycosylation suppresses human cytomegalovirus entry in human fibroblasts. Microb Pathog. 2019;138:103776 pubmed publisher

Minguzzi M, Guidotti S, Platano D, D Adamo S, Cetrullo S, Assirelli E, et al. Polyamine supplementation reduces DNA damage in adipose stem cells cultured in 3-D. Sci Rep. 2019;9:14269 pubmed publisher

Guo H, Li Y, Shen L, Wang T, Jia X, Liu L, et al. Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission. Sci Adv. 2019;5:eaax2166 pubmed publisher

Sarraf S, Sideris D, Giagtzoglou N, Ni L, Kankel M, Sen A, et al. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Rep. 2019;29:225-235.e5 pubmed publisher

Daniele L, Caughey J, Volland S, Sharp R, Dhingra A, Williams D, et al. Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B). Am J Physiol Cell Physiol. 2019;317:C1194-C1204 pubmed publisher

Gan R, Lin L, Xie J, Huang L, Ding L, Su B, et al. FLI-06 Intercepts Notch Signaling And Suppresses The Proliferation And Self-renewal Of Tongue Cancer Cells. Onco Targets Ther. 2019;12:7663-7674 pubmed publisher

Yu T, Gan S, Zhu Q, Dai D, Li N, Wang H, et al. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun. 2019;10:4353 pubmed publisher

Li N, Wang Y, Neri S, Zhen Y, Fong L, Qiao Y, et al. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019;10:4363 pubmed publisher

Huang J, Yin H, Yin P, Jian X, Song S, Luan J, et al. SR-BI Interactome Analysis Reveals a Proviral Role for UGGT1 in Hepatitis C Virus Entry. Front Microbiol. 2019;10:2043 pubmed publisher

Gargini R, Segura Collar B, Sanchez Gomez P. Novel Functions of the Neurodegenerative-Related Gene Tau in Cancer. Front Aging Neurosci. 2019;11:231 pubmed publisher

Hosseini M, Dousset L, Michon P, Mahfouf W, Muzotte E, Bergeron V, et al. UVB-induced DHODH upregulation, which is driven by STAT3, is a promising target for chemoprevention and combination therapy of photocarcinogenesis. Oncogenesis. 2019;8:52 pubmed publisher

Wu R, Young I, Chen Y, Chuang S, Toubaji A, Wu M. Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer. Nat Commun. 2019;10:4332 pubmed publisher

Jiang X, Shen T, Lu H, Shi C, Liu Z, Qin H, et al. Clinical significance and biological role of KLF17 as a tumour suppressor in colorectal cancer. Oncol Rep. 2019;42:2117-2129 pubmed publisher

Martin A, Jacquemyn M, Lipecka J, Chhuon C, Aushev V, Meunier B, et al. STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes. EMBO Rep. 2019;20:e48150 pubmed publisher

Liang Q, Zhang L, Wood R, Ji R, Boyce B, Schwarz E, et al. Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice. Am J Pathol. 2019;189:2516-2530 pubmed publisher

Mitroi D, Pereyra Gómez G, Soto Huelin B, Senovilla F, Kobayashi T, Esteban J, et al. NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation. EMBO Rep. 2019;20:e48143 pubmed publisher

Stepp M, Salazar González R, Hong K, Doll M, Hein D. N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines. J Oncol. 2019;2019:3860426 pubmed publisher

Garner K, Hull N, Sims A, Lamb R, Clarke R. The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts. J Mammary Gland Biol Neoplasia. 2019;24:245-256 pubmed publisher

Xie Y, Mansouri M, Rizk A, Berger P. Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. Sci Rep. 2019;9:13342 pubmed publisher

Daher C, Vimeux L, Stoeva R, Peranzoni E, Bismuth G, Wieduwild E, et al. Blockade of β-Adrenergic Receptors Improves CD8+ T-cell Priming and Cancer Vaccine Efficacy. Cancer Immunol Res. 2019;7:1849-1863 pubmed publisher

Morishita H, Zhao Y, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, et al. A critical role of VMP1 in lipoprotein secretion. elife. 2019;8: pubmed publisher

Hansen A, Hsieh T, Cattoglio C, Pustova I, Saldaña Meyer R, Reinberg D, et al. Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF. Mol Cell. 2019;76:395-411.e13 pubmed publisher

Jaldin Fincati J, Actis Dato V, Díaz N, Sanchez M, Barcelona P, Chiabrando G. Activated α2-Macroglobulin Regulates LRP1 Levels at the Plasma Membrane through the Activation of a Rab10-dependent Exocytic Pathway in Retinal Müller Glial Cells. Sci Rep. 2019;9:13234 pubmed publisher

Ding L, Su Y, Fassl A, Hinohara K, Qiu X, Harper N, et al. Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. Nat Commun. 2019;10:4182 pubmed publisher

Park J, Seo J, Ahn N, Park S, Hwang J, Nam J. UPF1/SMG7-dependent microRNA-mediated gene regulation. Nat Commun. 2019;10:4181 pubmed publisher

Kajiho H, Yamamoto Y, Sakisaka T. CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. Sci Rep. 2019;9:13152 pubmed publisher

Wu X, Lei C, Xia T, Zhong X, Yang Q, Shu H. Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination. Nat Commun. 2019;10:4115 pubmed publisher

Zhang Z, Zhang L, Wang B, Zhu X, Zhao L, Chu C, et al. RNF144B inhibits LPS-induced inflammatory responses via binding TBK1. J Leukoc Biol. 2019;106:1303-1311 pubmed publisher

Wu X, Fan Z, Chen M, Chen Y, Rong D, Cui Z, et al. Forkhead transcription factor FOXO3a mediates interferon-γ-induced MHC II transcription in macrophages. Immunology. 2019;158:304-313 pubmed publisher

Fecher C, Trovò L, Müller S, Snaidero N, Wettmarshausen J, Heink S, et al. Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019;22:1731-1742 pubmed publisher

Mitobe Y, Ikeda K, Suzuki T, Takagi K, Kawabata H, Horie Inoue K, et al. ESR1-Stabilizing Long Noncoding RNA TMPO-AS1 Promotes Hormone-Refractory Breast Cancer Progression. Mol Cell Biol. 2019;39: pubmed publisher

Zhao B, Lin J, Rong L, Wu S, Deng Z, Fatkhutdinov N, et al. ARID1A promotes genomic stability through protecting telomere cohesion. Nat Commun. 2019;10:4067 pubmed publisher

Han N, Jung M, Jeong Y, Son Y, Han S, Park S, et al. Plasma Fibrinogen-Like 1 as a Potential Biomarker for Radiation-Induced Liver Injury. Cells. 2019;8: pubmed publisher

Xu T, Qiu P, Zhang Y, Yu S, Xu G, Yang W. MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9. Hum Cell. 2019;32:548-556 pubmed publisher

Wang D, Hu X, Liu C, Jia Y, Bai Y, Cai C, et al. Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers. Cell Res. 2019;29:832-845 pubmed publisher

Kim Y, Kim H, Kim H, Gawk H, Bae S, Sim H, et al. FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer. Cancers (Basel). 2019;11: pubmed publisher

Gao G, Zhu C, Liu E, Nabi I. Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules. PLoS Biol. 2019;17:e3000355 pubmed publisher

Mohammad A, Assadian S, Couture F, Lefebvre K, El Assaad W, Barrès V, et al. V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. Oncotarget. 2019;10:4923-4936 pubmed publisher

Emami A, Shojaei S, da Silva Rosa S, Aghaei M, Samiei E, Vosoughi A, et al. Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition. Eur J Pharmacol. 2019;862:172616 pubmed publisher

Chakravarthi B, Dedigama Arachchige P, Carskadon S, Sundaram S, Li J, Wu K, et al. Pseudogene Associated Recurrent Gene Fusion in Prostate Cancer. Neoplasia. 2019;21:989-1002 pubmed publisher

Jackson M, Loring K, Homan C, Thai M, Määttänen L, Arvio M, et al. Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females. Life Sci Alliance. 2019;2: pubmed publisher

Wigger L, Casals Casas C, Baruchet M, Trang K, Pradervand S, Naldi A, et al. System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells. PLoS ONE. 2019;14:e0220894 pubmed publisher

Cao P, Luo W, Li C, Tong Z, Zheng Z, Zhou L, et al. The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors. PLoS Pathog. 2019;15:e1007983 pubmed publisher

Yoshitane H, Asano Y, Sagami A, Sakai S, Suzuki Y, Okamura H, et al. Functional D-box sequences reset the circadian clock and drive mRNA rhythms. Commun Biol. 2019;2:300 pubmed publisher

Chen S, Gao W, Zhang M, Chan J, Wong T. Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer. Oncol Lett. 2019;18:2132-2139 pubmed publisher

Ritter A, Kreis N, Roth S, Friemel A, Jennewein L, Eichbaum C, et al. Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase. Stem Cell Res Ther. 2019;10:255 pubmed publisher

Koppel N, Friese M, Cardasis H, Neubert T, Burden S. Vezatin is required for the maturation of the neuromuscular synapse. Mol Biol Cell. 2019;30:2571-2583 pubmed publisher

Zambom F, Oliveira K, Foresto Neto O, Faustino V, Ávila V, Albino A, et al. Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload. Am J Physiol Renal Physiol. 2019;317:F1058-F1067 pubmed publisher

Boso D, Rampazzo E, Zanon C, Bresolin S, Maule F, Porcù E, et al. HIF-1α/Wnt signaling-dependent control of gene transcription regulates neuronal differentiation of glioblastoma stem cells. Theranostics. 2019;9:4860-4877 pubmed publisher

Kodrič K, Zupan J, Kranjc T, Komadina R, Mlakar V, Marc J, et al. Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis. Exp Mol Med. 2019;51:1-16 pubmed publisher

Sun G, Zhang X, Liu Z, Zhu S, Shen P, Zhang H, et al. The Adiponectin-AdipoR1 Axis Mediates Tumor Progression and Tyrosine Kinase Inhibitor Resistance in Metastatic Renal Cell Carcinoma. Neoplasia. 2019;21:921-931 pubmed publisher

Künzi L, Holt G. Cigarette smoke activates the parthanatos pathway of cell death in human bronchial epithelial cells. Cell Death Discov. 2019;5:127 pubmed publisher

Reyes Martínez C, Nguyen Q, Kassan M, Gonzalez A. (Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells. Front Pharmacol. 2019;10:803 pubmed publisher

Huang L, Hu C, Chao H, Zhang Y, Li Y, Hou J, et al. Drug-resistant endothelial cells facilitate progression, EMT and chemoresistance in nasopharyngeal carcinoma via exosomes. Cell Signal. 2019;63:109385 pubmed publisher

Kaczmarczyk L, Bansal V, Rajput A, Rahman R, Krzyżak W, Degen J, et al. Tagger-A Swiss army knife for multiomics to dissect cell type-specific mechanisms of gene expression in mice. PLoS Biol. 2019;17:e3000374 pubmed publisher

Ran Y, Xiong M, Xu Z, Luo W, Wang S, Wang Y. YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking. J Immunol. 2019;203:1560-1570 pubmed publisher

Hernández Camarero P, López Ruiz E, Griñán Lisón C, Garcia M, Chocarro Wrona C, Marchal J, et al. Pancreatic (pro)enzymes treatment suppresses BXPC-3 pancreatic Cancer Stem Cell subpopulation and impairs tumour engrafting. Sci Rep. 2019;9:11359 pubmed publisher

Buckley M, Williams J, Chan Y, Laubertova L, Gallagher H, Moss J, et al. The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways. Sci Rep. 2019;9:11317 pubmed publisher

Salvermoser L, Dressel S, Schleißheimer S, Stangl S, Diederichs C, Wergin M, et al. 7Hsp70 serum levels in pet dogs-a potential diagnostic biomarker for spontaneous round cell tumors. Cell Stress Chaperones. 2019;24:969-978 pubmed publisher

Erttmann S, Gekara N. Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity. Nat Commun. 2019;10:3493 pubmed publisher

Sun Y, Kosinska W, Guttenplan J. E-cigarette Aerosol Condensate Enhances Metabolism of Benzo(a)pyrene to Genotoxic Products, and Induces CYP1A1 and CYP1B1, Likely by Activation of the Aryl Hydrocarbon Receptor. Int J Environ Res Public Health. 2019;16: pubmed publisher

Korkmaz G, Manber Z, Lopes R, Prekovic S, Schuurman K, Kim Y, et al. A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation. Nucleic Acids Res. 2019;47:9557-9572 pubmed publisher

Guo Y, Wei X, Yan H, Qin Y, Yan S, Liu J, et al. TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models. FASEB J. 2019;:fj201900992R pubmed publisher

Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, et al. NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells. Am J Physiol Cell Physiol. 2019;317:C737-C748 pubmed publisher

Cavalcante S, Silva C, Sola P, Tanaka L, Oba Shinjo S, Marie S. ATRX-DAXX Complex Expression Levels and Telomere Length in Normal Young and Elder Autopsy Human Brains. DNA Cell Biol. 2019;38:955-961 pubmed publisher

Chung K, Hsu C, Fan L, Huang Z, Bhatia D, Chen Y, et al. Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Commun. 2019;10:3390 pubmed publisher

Lingaraju M, Johnsen D, Schlundt A, Langer L, Basquin J, Sattler M, et al. The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nat Commun. 2019;10:3393 pubmed publisher

Fan Z, Li N, Xu Z, Wu J, Fan X, Xu Y. An interaction between MKL1, BRG1, and C/EBPβ mediates palmitate induced CRP transcription in hepatocytes. Biochim Biophys Acta Gene Regul Mech. 2019;1862:194412 pubmed publisher

Wei M, Zhu Z, Wu J, Wang Y, Geng J, Qin Z. DRAM1 deficiency affects the organization and function of the Golgi apparatus. Cell Signal. 2019;63:109375 pubmed publisher

Orvedahl A, McAllaster M, Sansone A, Dunlap B, Desai C, Wang Y, et al. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. Proc Natl Acad Sci U S A. 2019;116:16497-16506 pubmed publisher

Antunes K, Fachi J, de Paula R, da Silva E, Pral L, dos Santos A, et al. Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat Commun. 2019;10:3273 pubmed publisher

Wessler L, de Miranda Ramos V, Bittencourt Pasquali M, Fonseca Moreira J, de Oliveira J, Scaini G, et al. Administration of branched-chain amino acids increases the susceptibility to lipopolysaccharide-induced inflammation in young Wistar rats. Int J Dev Neurosci. 2019;78:210-214 pubmed publisher

Cheng Z, Yu C, Cui S, Wang H, Jin H, Wang C, et al. circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1. Nat Commun. 2019;10:3200 pubmed publisher

Schreiber K, Arriola Apelo S, Yu D, Brinkman J, Velarde M, Syed F, et al. A novel rapamycin analog is highly selective for mTORC1 in vivo. Nat Commun. 2019;10:3194 pubmed publisher

Choi G, Zhou P, Yuen C, Chan B, Xu F, Bao S, et al. Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9. Nat Methods. 2019;16:722-730 pubmed publisher

Chan L, Li C, Xia W, Hsu J, Lee H, Cha J, et al. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest. 2019;129:3324-3338 pubmed publisher

Mandati V, Del Maestro L, Dingli F, Lombard B, Loew D, Molinie N, et al. Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression. J Biol Chem. 2019;294:12992-13005 pubmed publisher

Morcelle C, Menoyo S, Morón Duran F, Tauler A, Kozma S, Thomas G, et al. Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53 Independent of Increased Ribosome Content. Cancer Res. 2019;79:4348-4359 pubmed publisher

Ficarelli M, Wilson H, Pedro Galão R, Mazzon M, Antzin Anduetza I, Marsh M, et al. KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides. elife. 2019;8: pubmed publisher

Lee Y, Riopel M, Cabrales P, Bandyopadhyay G. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv. 2019;5:eaaw4176 pubmed publisher

Zhang R, Wang X, Qu J, Liu B, Zhang P, Zhang T, et al. Caloric Restriction Induces MicroRNAs to Improve Mitochondrial Proteostasis. iScience. 2019;17:155-166 pubmed publisher

De Nuccio C, Bernardo A, Ferrante A, Pepponi R, Martire A, Falchi M, et al. Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes. Sci Rep. 2019;9:9782 pubmed publisher

Yao J, Chen Y, Nguyen D, Thompson Z, Eroshkin A, Nerlakanti N, et al. The Homeobox gene, HOXB13, Regulates a Mitotic Protein-Kinase Interaction Network in Metastatic Prostate Cancers. Sci Rep. 2019;9:9715 pubmed publisher

Ahmed S, Droge P. Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology. Mol Oncol. 2019;13:2062-2078 pubmed publisher

Dou Y, Xing J, Kong G, Wang G, Lou X, Xiao X, et al. Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions. J Immunol. 2019;203:873-880 pubmed publisher

Zhang Y, Du X, Liu M, Tang F, Zhang P, Ai C, et al. Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy. Cell Res. 2019;29:609-627 pubmed publisher

Soomro I, Hong A, Li Z, Duncan J, Skolnik E. Discoidin Domain Receptor 1 (DDR1) tyrosine kinase is upregulated in PKD kidneys but does not play a role in the pathogenesis of polycystic kidney disease. PLoS ONE. 2019;14:e0211670 pubmed publisher

Lin N, Dong X, Wang T, He W, Wei J, Wu H, et al. Characteristics of olfactory ensheathing cells and microarray analysis in Tupaia belangeri (Wagner, 1841). Mol Med Rep. 2019;20:1819-1825 pubmed publisher

Martín Maestro P, Gargini R, Garcia E, Simon D, Avila J, García Escudero V. Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. J Alzheimers Dis. 2019;: pubmed publisher

Kapplusch F, Schulze F, Rabe Matschewsky S, Russ S, Herbig M, Heymann M, et al. CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability. Clin Immunol. 2019;: pubmed publisher

Cammalleri M, Dal Monte M, Locri F, Pecci V, De Rosa M, Pavone V, et al. The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model. J Cell Mol Med. 2019;23:5176-5192 pubmed publisher

Moulis M, Grousset E, Faccini J, Richetin K, Thomas G, Vindis C. The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites. Cells. 2019;8: pubmed publisher

Kawaue T, Shitamukai A, Nagasaka A, Tsunekawa Y, Shinoda T, Saito K, et al. Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development. Nat Commun. 2019;10:2780 pubmed publisher

Yao J, Wu X, Zhang D, Wang L, Zhang L, Reynolds E, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019;129:3121-3133 pubmed publisher

Zhang Q, Zhu W, Xu F, Dai X, Shi L, Cai W, et al. The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury. PLoS Biol. 2019;17:e3000330 pubmed publisher

Kumar Singh M, Martin A, Joffre C, Zago G, Camonis J, Coppey M, et al. Localization of RalB signaling at endomembrane compartments and its modulation by autophagy. Sci Rep. 2019;9:8910 pubmed publisher

Lyu C, Cai X. A GFP-tagged version of the pseudorabies virus protein UL56 localizes to the Golgi and trans-Golgi network through a predicted C-terminal leucine-rich helix in transfected cells. Virol J. 2019;16:81 pubmed publisher

Edson A, Hushagen H, Frøyset A, Elda I, Khan E, Di Stefano A, et al. Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1. Mol Neurobiol. 2019;: pubmed publisher

Kuldkepp A, Karakai M, Toomsoo E, Reinsalu O, Kurg R. Cancer-testis antigens MAGEA proteins are incorporated into extracellular vesicles released by cells. Oncotarget. 2019;10:3694-3708 pubmed publisher

Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, et al. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Rep. 2019;27:3587-3601.e4 pubmed publisher

Lin J, Yang L, Ren Z, Mu D, Li Y, Yan J, et al. Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling. Drug Des Devel Ther. 2019;13:1843-1853 pubmed publisher

Sun X, Wang N, Wang X, Sun L, Li Y, Cui C. AMPA Receptor in Ventromedial Prefrontal Cortex Plays Different Roles in the Recent and Remote Retrieval of Morphine-Associated Memory. Neurochem Res. 2019;: pubmed publisher

Cattoglio C, Pustova I, Walther N, Ho J, Hantsche Grininger M, Inouye C, et al. Determining cellular CTCF and cohesin abundances to constrain 3D genome models. elife. 2019;8: pubmed publisher

Sharma Y, Miladi M, Dukare S, Boulay K, Caudron Herger M, Groß M, et al. A pan-cancer analysis of synonymous mutations. Nat Commun. 2019;10:2569 pubmed publisher

Mattson A, Begun D, Molstad D, Meyer M, Oursler M, Westendorf J, et al. Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice. J Biol Chem. 2019;294:11772-11784 pubmed publisher

Gorrell R, Totten M, Schoerning L, Newby J, Geyman L, Lawless W, et al. Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody. BMC Res Notes. 2019;12:331 pubmed publisher

Bignon E, Albornoz A, Guardado Calvo P, Rey F, Tischler N. Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface. elife. 2019;8: pubmed publisher

Shang Y, Li Y, Zhang Y, Wang J. ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma. Biochem Biophys Res Commun. 2019;: pubmed publisher

Yang Y, Liu L, Li M, Cheng X, Fang M, Zeng Q, et al. The chromatin remodeling protein BRG1 links ELOVL3 trans-activation to prostate cancer metastasis. Biochim Biophys Acta Gene Regul Mech. 2019;: pubmed publisher

Cope N, Novak B, Candelora C, Wong K, Cavallo M, Gunderwala A, et al. Biochemical Characterization of Full-Length Oncogenic BRAFV600E together with Molecular Dynamics Simulations Provide Insight into the Activation and Inhibition Mechanisms of RAF Kinases. Chembiochem. 2019;20:2850-2861 pubmed publisher

de Freitas Carvalho M, Lage N, de Souza Paulino A, Pereira R, de Almeida L, da Silva T, et al. Effects of açai on oxidative stress, ER stress, and inflammation-related parameters in mice with high fat diet-fed induced NAFLD. Sci Rep. 2019;9:8107 pubmed publisher

Yim S, Clish C, Gladyshev V. Selenium Deficiency Is Associated with Pro-longevity Mechanisms. Cell Rep. 2019;27:2785-2797.e3 pubmed publisher

Starr C, Gorbatyuk M. Delineating the role of eIF2α in retinal degeneration. Cell Death Dis. 2019;10:409 pubmed publisher

Charitou T, Srihari S, Lynn M, Jarboui M, Fasterius E, Moldovan M, et al. Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation. Br J Cancer. 2019;: pubmed publisher

Lei C, Wu X, Zhong X, Jiang L, Zhong B, Shu H. USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1. J Immunol. 2019;203:259-268 pubmed publisher

van de Kooij B, Creixell P, van Vlimmeren A, Joughin B, Miller C, Haider N, et al. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs. elife. 2019;8: pubmed publisher

Legrand J, Chan A, La H, Rossello F, Ankö M, Fuller Pace F, et al. DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia. Nat Commun. 2019;10:2278 pubmed publisher

Zhu Y, Zhao Y, Zou L, Zhang D, Aki D, Liu Y. The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control. J Exp Med. 2019;: pubmed publisher

Thomas R, Srivastava S, Katreddy R, Sobieski J, Weihua Z. Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors. Int J Mol Sci. 2019;20: pubmed publisher

Santiago Gómez A, Kedward T, Simões B, Dragoni I, NicAmhlaoibh R, Trivier E, et al. PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer. Cancer Lett. 2019;: pubmed publisher

Hemmati S, Sinclair T, Tong M, Bartholdy B, Okabe R, Ames K, et al. PI3 kinase alpha and delta promote hematopoietic stem cell activation. JCI Insight. 2019;5: pubmed publisher

Liu F, Knight T, Su Y, Edwards H, Wang G, Wang Y, et al. Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo. Target Oncol. 2019;: pubmed publisher

Sellers K, Allen T, Bousamra M, Tan J, Méndez Lucas A, Lin W, et al. Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes. Br J Cancer. 2019;: pubmed publisher

Wang H, Lyu Y, Liao Q, Jin L, Xu L, Hu Y, et al. Effects of Remote Ischemic Preconditioning in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery. Front Physiol. 2019;10:495 pubmed publisher

Grainger S, Nguyen N, Richter J, Setayesh J, Lonquich B, Oon C, et al. EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nat Cell Biol. 2019;: pubmed publisher

Lypova N, Lanceta L, Gibson A, Vega S, Garza Morales R, McMasters K, et al. Targeting Palbociclib-Resistant Estrogen Receptor-Positive Breast Cancer Cells via Oncolytic Virotherapy. Cancers (Basel). 2019;11: pubmed publisher

Alhothali M, Mathew M, Iyer G, Lawrence H, Yang S, Chellappan S, et al. Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC. Int J Mol Sci. 2019;20: pubmed publisher

Li H, Yu Y, Zhao Y, Wu D, Yu X, Lu J, et al. Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling. Cancer Lett. 2019;: pubmed publisher

Ramms B, Patel S, Nora C, Pessentheiner A, Chang M, Green C, et al. ApoC-III ASO Promotes Tissue LPL Activity in Absence of ApoE-Mediated TRL Clearance. J Lipid Res. 2019;: pubmed publisher

Choi S, López González R, Krishnan G, Phillips H, Li A, Seeley W, et al. C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo. Nat Neurosci. 2019;22:851-862 pubmed publisher

Sowamber R, Chehade R, Bitar M, Dodds L, Milea A, Slomovitz B, et al. CCAAT/enhancer binding protein delta (C/EBPδ) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma. EBioMedicine. 2019;: pubmed publisher

Schmöhl F, Peters V, Schmitt C, Poschet G, Buttner M, Li X, et al. CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications. Cell Mol Life Sci. 2019;: pubmed publisher

Liu S, Ando F, Fujita Y, Liu J, Maeda T, Shen X, et al. A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice. J Biol Chem. 2019;294:9760-9770 pubmed publisher

Demian W, Persaud A, Jiang C, Coyaud E, Liu S, Kapus A, et al. The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1. Cell Rep. 2019;27:1886-1896.e6 pubmed publisher

Ahmed S, Ramani P, Wong S, Zhao X, Ivanyi Nagy R, Leong T, et al. The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity. PLoS ONE. 2019;14:e0215696 pubmed publisher

Zhang K, Yang Q, Yang L, Li Y, Wang X, Li Y, et al. CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice. J Clin Invest. 2019;130:2333-2350 pubmed publisher

Custer S, Astroski J, Li H, Androphy E. Interaction between alpha-COP and SMN ameliorates disease phenotype in a mouse model of spinal muscular atrophy. Biochem Biophys Res Commun. 2019;: pubmed publisher

Koch S, Damas M, Freise A, Hage E, Dhingra A, Rückert J, et al. Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression. PLoS Pathog. 2019;15:e1007743 pubmed publisher

Chang E, Mo W, Doo H, Lee J, Park H, Choi B, et al. Aminosalicylic acid reduces ER stress and Schwann cell death induced by MPZ mutations. Int J Mol Med. 2019;44:125-134 pubmed publisher

Kim B, Kim J, Sim D, Nam M, Jung J, Shim B, et al. Inhibition of JAK2/STAT3 and activation of caspase‑9/3 are involved in KYS05090S‑induced apoptosis in ovarian cancer cells. Int J Oncol. 2019;55:203-210 pubmed publisher

Wood K, Holmes R, Erbe D, Liebow A, Fargue S, Knight J. Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity. Biochim Biophys Acta Mol Basis Dis. 2019;1865:2203-2209 pubmed publisher

Nakamura S, Noguchi T, Inoue Y, Sakurai S, Nishinaka A, Hida Y, et al. Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability. Invest Ophthalmol Vis Sci. 2019;60:1943-1952 pubmed publisher

Sghaier R, Zarrouk A, Nury T, Badreddine I, O Brien N, Mackrill J, et al. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free Radic Res. 2019;53:535-561 pubmed publisher

Koike A, Hanatani M, Fujimori K. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;: pubmed publisher

Sassi K, Nury T, Zarrouk A, Sghaier R, Khalafi Nezhad A, Vejux A, et al. Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells. J Steroid Biochem Mol Biol. 2019;191:105371 pubmed publisher

Nunez K, Frank A, Gonzalez Rosario J, Galliano G, Bridle K, Crawford D, et al. Interleukin-33 / Cyclin D1 imbalance in severe liver steatosis predicts susceptibility to ischemia reperfusion injury. PLoS ONE. 2019;14:e0216242 pubmed publisher

Brandsma A, Bondza S, Evers M, Koutstaal R, Nederend M, Jansen J, et al. Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG. Front Immunol. 2019;10:704 pubmed publisher

Deng J, Jiang P, Yang T, Huang M, Qi W, Zhou T, et al. Targeting β3-adrenergic receptor signaling inhibits neuroblastoma cell growth via suppressing the mTOR pathway. Biochem Biophys Res Commun. 2019;514:295-300 pubmed publisher

Blázquez Medela A, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, et al. Noggin depletion in adipocytes promotes obesity in mice. Mol Metab. 2019;25:50-63 pubmed publisher

Leguina Ruzzi A, Ortiz Diban R, Velarde V. The 12-HHT/BLT2/NO Axis Is Associated to the Wound Healing and Skin Condition in Different Glycaemic States. Med Sci (Basel). 2019;7: pubmed publisher

Martufi M, Good R, Rapiteanu R, Schmidt T, Patili E, Tvermosegaard K, et al. Single-Step, High-Efficiency CRISPR-Cas9 Genome Editing in Primary Human Disease-Derived Fibroblasts. CRISPR J. 2019;2:31-40 pubmed publisher

Lübbehüsen C, Lüke J, Seeling C, Mellert K, Marienfeld R, von Baer A, et al. Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway. Sci Rep. 2019;9:6458 pubmed publisher

Sak M, Zumbar C, King P, Li X, Mifsud C, Usubalieva A, et al. Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells. J Neurooncol. 2019;143:231-240 pubmed publisher

García Diaz B, Bachelin C, Coulpier F, Gerschenfeld G, Deboux C, Zujovic V, et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol. 2019;: pubmed publisher

Zecchinati F, Barranco M, Arana M, Tocchetti G, Domínguez C, Perdomo V, et al. Reversion of down-regulation of intestinal multidrug resistance-associated protein 2 in fructose-fed rats by geraniol and vitamin C: Potential role of inflammatory response and oxidative stress. J Nutr Biochem. 2019;68:7-15 pubmed publisher

Yin H, Yin P, Zhao H, Zhang N, Jian X, Song S, et al. Intraviral interactome of Chikungunya virus reveals the homo-oligomerization and palmitoylation of structural protein TF. Biochem Biophys Res Commun. 2019;513:919-924 pubmed publisher

Gil Iturbe E, Arbones Mainar J, Moreno Aliaga M, Lostao M. GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice. Acta Physiol (Oxf). 2019;226:e13283 pubmed publisher

Li Y, Jian X, Yin P, Zhu G, Zhang L. Elucidating the Host Interactome of EV-A71 2C Reveals Viral Dependency Factors. Front Microbiol. 2019;10:636 pubmed publisher

Imai T, Iwata S, Hirayama T, Nagasawa H, Nakamura S, Shimazawa M, et al. Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage. Sci Rep. 2019;9:6228 pubmed publisher

Yamane D, Feng H, Rivera Serrano E, Selitsky S, Hirai Yuki A, Das A, et al. Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses. Nat Microbiol. 2019;4:1096-1104 pubmed publisher

Faes S, Santoro T, Troquier L, De Souza Silva O, Dormond O. Rebound pathway overactivation by cancer cells following discontinuation of PI3K or mTOR inhibition promotes cancer cell growth. Biochem Biophys Res Commun. 2019;513:546-552 pubmed publisher

Gao R, Kanasaki K, Li J, Kitada M, Okazaki T, Koya D. βklotho is essential for the anti-endothelial mesenchymal transition effects of N-acetyl-seryl-aspartyl-lysyl-proline. FEBS Open Bio. 2019;9:1029-1038 pubmed publisher

Li H, Yang F, Chai L, Zhang L, Li S, Xu Z, et al. CCAAT/Enhancer Binding Protein β-Mediated MMP3 Upregulation Promotes Esophageal Squamous Cell Cancer Invasion In Vitro and Is Associated with Metastasis in Human Patients. Genet Test Mol Biomarkers. 2019;23:304-309 pubmed publisher

Yu Y, Zhao Y, Fan Y, Chen Z, Li H, Lu J, et al. Inhibition of Ubiquitin-Specific Protease 14 Suppresses Cell Proliferation and Synergizes with Chemotherapeutic Agents in Neuroblastoma. Mol Cancer Ther. 2019;18:1045-1056 pubmed publisher

Kukita A, Sone K, Oda K, Hamamoto R, Kaneko S, Komatsu M, et al. Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas. Biochem Biophys Res Commun. 2019;513:340-346 pubmed publisher

Li Z, Li P, Lu Y, Sun D, Zhang X, Xu Y. A non-autonomous role of MKL1 in the activation of hepatic stellate cells. Biochim Biophys Acta Gene Regul Mech. 2019;1862:609-618 pubmed publisher

Yang Y, Liu L, Fang M, Bai H, Xu Y. The chromatin remodeling protein BRM regulates the transcription of tight junction proteins: Implication in breast cancer metastasis. Biochim Biophys Acta Gene Regul Mech. 2019;1862:547-556 pubmed publisher

Previte D, Martins C, O Connor E, Marre M, Coudriet G, Beck N, et al. Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells. Cell Rep. 2019;27:129-141.e4 pubmed publisher

Yin N, Zhang H, Ye R, Dong M, Lin J, Zhou H, et al. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. Int J Mol Sci. 2019;20: pubmed publisher

Kim J, Gautam J, Kim J, Kim J, Kang K. Inhibition of tumor growth and angiogenesis of tamoxifen-resistant breast cancer cells by ruxolitinib, a selective JAK2 inhibitor. Oncol Lett. 2019;17:3981-3989 pubmed publisher

Du X, McCarthny C, Notaras M, van den Buuse M, Hill R. Effect of adolescent androgen manipulation on psychosis-like behaviour in adulthood in BDNF heterozygous and control mice. Horm Behav. 2019;112:32-41 pubmed publisher

Sauer F, Klemm T, Kollampally R, Tessmer I, Nair R, Popov N, et al. Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities. Mol Cell. 2019;74:421-435.e10 pubmed publisher

Pang Y, Yamamoto H, Sakamoto H, Oku M, Mutungi J, Sahani M, et al. Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system. Nat Struct Mol Biol. 2019;: pubmed publisher

Roy S, Saha S, Gupta P, Ukil A, Das P. Crosstalk of PD-1 signaling with the SIRT1/FOXO-1 axis during the progression of visceral leishmaniasis. J Cell Sci. 2019;132: pubmed publisher

Murali S, Aroankins T, Moeller H, Fenton R. The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance. Cells. 2019;8: pubmed publisher

Okawa Y, Hoshino A, Ariyoshi M, Kaimoto S, Tateishi S, Ono K, et al. Ablation of cardiac TIGAR preserves myocardial energetics and cardiac function in the pressure overload heart failure model. Am J Physiol Heart Circ Physiol. 2019;316:H1366-H1377 pubmed publisher

Fedeli C, Filadi R, Rossi A, Mammucari C, Pizzo P. PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. Autophagy. 2019;15:2044-2062 pubmed publisher

Zhang Y, Yuan Y, Li Z, Chen H, Fang M, Xiao P, et al. An interaction between BRG1 and histone modifying enzymes mediates lipopolysaccharide-induced proinflammatory cytokines in vascular endothelial cells. J Cell Biochem. 2019;120:13216-13225 pubmed publisher

Jiang L, Malik N, Acedo P, Zawacka Pankau J. Protoporphyrin IX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and induces apoptosis in B-cell chronic lymphocytic leukemia cells. Cell Death Discov. 2019;5:77 pubmed publisher

Urreizti R, Mayer K, Evrony G, Said E, Castilla Vallmanya L, Cody N, et al. DPH1 syndrome: two novel variants and structural and functional analyses of seven missense variants identified in syndromic patients. Eur J Hum Genet. 2019;: pubmed publisher

Capmany A, Yoshimura A, Kerdous R, Caorsi V, Lescure A, del Nery E, et al. MYO1C stabilizes actin and facilitates the arrival of transport carriers at the Golgi complex. J Cell Sci. 2019;132: pubmed publisher

Yang H, Shen H, Li J, Guo L. SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance. Autophagy. 2019;:1-19 pubmed publisher

Ketteler J, Panic A, Reis H, Wittka A, Maier P, Herskind C, et al. Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1. J Clin Med. 2019;8: pubmed publisher

Zou W, Pu T, Feng W, Lu M, Zheng Y, Du R, et al. Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated α-synuclein. Transl Neurodegener. 2019;8:7 pubmed publisher

Koebis M, Urata S, Shinoda Y, Okabe S, Yamasoba T, Nakao K, et al. LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing. Mol Brain. 2019;12:20 pubmed publisher

Finn J, Sottoriva K, Pajcini K, KITAJEWSKI J, Chen C, Zhang W, et al. Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair. Cell Rep. 2019;26:2942-2954.e5 pubmed publisher

Ren J, Finney R, Ni K, Cam M, Muegge K. The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors. Epigenetics. 2019;14:277-293 pubmed publisher

Askvig J, Watt J. Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. J Comp Neurol. 2019;: pubmed publisher

Johansson J, Nászai M, Hodder M, Pickering K, Miller B, Ridgway R, et al. RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Cell Stem Cell. 2019;24:592-607.e7 pubmed publisher

Raab M, Sanhaji M, Zhou S, Rodel F, El Balat A, Becker S, et al. Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability. Neoplasia. 2019;21:363-375 pubmed publisher

Hayes K, Batsomboon P, Chen W, Johnson B, Becker A, Eschrich S, et al. Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma. Bioorg Med Chem. 2019;27:1479-1488 pubmed publisher

Ciołczyk Wierzbicka D, Zarzycka M, Gil D, Laidler P. mTOR inhibitor Everolimus-induced apoptosis in melanoma cells. J Cell Commun Signal. 2019;: pubmed publisher

Khan G, Bhagat S, Alam M. PGE2 -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors. J Leukoc Biol. 2019;105:705-717 pubmed publisher

Borgo C, Franchin C, Cesaro L, Zaramella S, Arrigoni G, Salvi M, et al. A proteomics analysis of CK2β(-/-) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit. FEBS J. 2019;286:1561-1575 pubmed publisher

Bhat A, Palanichamy Kala M, Rao V, Pignata L, Lim H, Suriyamurthy S, et al. Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma. Cancer Res. 2019;79:2232-2243 pubmed publisher

Zhang X, Zhang J, Sun H, Liu X, Zheng Y, Xu D, et al. Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis. Cell Mol Gastroenterol Hepatol. 2019;7:763-781 pubmed publisher

Weng T, Ko J, Masamha C, Xia Z, Xiang Y, Chen N, et al. Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation. J Clin Invest. 2019;130: pubmed publisher

Wang Z, Katsaros D, Biglia N, Shen Y, Loo L, Yu X, et al. ERα upregulates the expression of long non-coding RNA LINC00472 which suppresses the phosphorylation of NF-κB in breast cancer. Breast Cancer Res Treat. 2019;175:353-368 pubmed publisher

Sun L, Yuan Y, Chen J, Ma C, Xu Y. Brahma related gene 1 (BRG1) regulates breast cancer cell migration and invasion by activating MUC1 transcription. Biochem Biophys Res Commun. 2019;: pubmed publisher

Greotti E, Capitanio P, Wong A, Pozzan T, Pizzo P, Pendin D. Familial Alzheimer's disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis. Cell Calcium. 2019;79:44-56 pubmed publisher

Eldahshan W, Ishrat T, Pillai B, Sayed M, Alwhaibi A, Fouda A, et al. Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study. Am J Physiol Heart Circ Physiol. 2019;316:H1192-H1201 pubmed publisher

Acedo P, Fernandes A, Zawacka Pankau J. Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors. Future Sci OA. 2019;5:FSO366 pubmed publisher

Shen Z, Zhu L, Zhang C, Cui X, Lu J. Overexpression of BHLHE41, correlated with DNA hypomethylation in 3'UTR region, promotes the growth of human clear cell renal cell carcinoma. Oncol Rep. 2019;41:2137-2147 pubmed publisher

Xie T, Chen H, Shen S, Huang T, Huang B, Hu G, et al. Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling. Int J Mol Med. 2019;43:1961-1968 pubmed publisher

Zhang C, Ye S, Ni J, Cai T, Liu Y, Huang D, et al. STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion. Cell Death Differ. 2019;: pubmed publisher

Xing X, Zhang J, Wu K, Cao B, Li X, Jiang F, et al. Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice. Sci Rep. 2019;9:3041 pubmed publisher

Cáceres B, Ramirez A, Carrillo E, Jiménez G, Griñán Lisón C, López Ruiz E, et al. Deciphering the Mechanism of Action Involved in Enhanced Suicide Gene Colon Cancer Cell Killer Effect Mediated by Gef and Apoptin. Cancers (Basel). 2019;11: pubmed publisher

Sakai Y, Kassai H, Nakayama H, Fukaya M, Maeda T, Nakao K, et al. Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells. Sci Rep. 2019;9:2799 pubmed publisher

Studentsova V, Knapp E, Loiselle A. Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss. Bone Rep. 2019;10:100197 pubmed publisher

Ahn M, Anderson D, Zhang Q, Tan C, Lim B, Luko K, et al. Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nat Microbiol. 2019;4:789-799 pubmed publisher

Karaszi K, Szabó S, Juhász K, Kiraly P, Kocsis Deák B, Hargitai B, et al. Increased placental expression of Placental Protein 5 (PP5) / Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion?. Placenta. 2019;76:30-39 pubmed publisher

Wang H, Cheung F, Stoll A, Rockwell P, Figueiredo Pereira M. Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1436-1450 pubmed publisher

Song C, Charli A, Luo J, Riaz Z, Jin H, Anantharam V, et al. Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity. Toxicol Sci. 2019;169:333-352 pubmed publisher

Kobayashi S, Contractor T, Vosburgh E, Du Y, Tang L, Clausen R, et al. Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors. Oncogenesis. 2019;8:16 pubmed publisher

Walker S, Wankell M, Ho V, White R, Deo N, Devine C, et al. Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model. PLoS ONE. 2019;14:e0212860 pubmed publisher

Watts E, Heidenreich D, Tucker E, Raab M, Strebhardt K, Chesler L, et al. Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity. J Med Chem. 2019;62:2618-2637 pubmed publisher

Lee J, Zhang Y, Eoh K, Sharma R, Sanmamed M, Wu J, et al. The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer. J Thorac Oncol. 2019;14:1046-1060 pubmed publisher

Dufour F, Silina L, Neyret Kahn H, Moreno Vega A, Krucker C, Karboul N, et al. TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer. Br J Cancer. 2019;120:555-564 pubmed publisher

Maio N, Kim K, Holmes Hampton G, Singh A, Rouault T. Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica. 2019;: pubmed publisher

Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori M, Tjandra D, et al. Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases. J Mol Biol. 2019;: pubmed publisher

Zhang J, Fujiwara Y, Yamamoto S, Shibuya H. A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. Nat Commun. 2019;10:722 pubmed publisher

Akino N, Wada Hiraike O, Isono W, Terao H, Honjo H, Miyamoto Y, et al. Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary. Reprod Biol Endocrinol. 2019;17:23 pubmed publisher

Guida M, Zanon A, Montibeller L, Lavdas A, Ladurner J, Pischedda F, et al. Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells. Int J Mol Sci. 2019;20: pubmed publisher

Baquero J, Benitez Buelga C, Fernandez V, Urioste M, García Gimenez J, Perona R, et al. A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers. Mol Oncol. 2019;13:1110-1120 pubmed publisher

Xiong J, Wang S, Chen T, Shu X, Mo X, Chang G, et al. Verteporfin blocks Clusterin which is required for survival of gastric cancer stem cell by modulating HSP90 function. Int J Biol Sci. 2019;15:312-324 pubmed publisher

Nahapetyan H, Moulis M, Grousset E, Faccini J, Grazide M, Mucher E, et al. Altered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype. Cell Death Dis. 2019;10:119 pubmed publisher

Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher

Park M, Yao Y, Xia W, Setijono S, Kim J, Vila I, et al. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nat Commun. 2019;10:636 pubmed publisher

Minaidou A, Nicolaou P, Christodoulou K. Deregulation of LRSAM1 expression impairs the levels of TSG101, UBE2N, VPS28, MDM2 and EGFR. PLoS ONE. 2019;14:e0211814 pubmed publisher

Wang Y, Chen Y, Chen J, Wang L, Nie L, Long J, et al. The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope. Nat Commun. 2019;10:564 pubmed publisher

Yoshitomi Y, Osada H, Satake H, Kojima M, Saito Takatsuji H, Ikeda T, et al. Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition. Biol Open. 2019;8: pubmed publisher

Weng X, Zhang Y, Li Z, Yu L, Xu F, Fang M, et al. Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1. Biochim Biophys Acta Gene Regul Mech. 2019;1862:163-172 pubmed publisher

Krieger J, Riedl P, Stifter K, Roman Sosa G, Seufferlein T, Wagner M, et al. Endogenously Expressed Antigens Bind Mammalian RNA via Cationic Domains that Enhance Priming of Effector CD8 T Cells by DNA Vaccination. Mol Ther. 2019;27:661-672 pubmed publisher

Zhao M, Cheng X, Lin X, Han Y, Zhou Y, Zhao T, et al. Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats. Behav Brain Res. 2019;363:30-37 pubmed publisher

Antonioli E, Torres N, Ferretti M, Piccinato C, Sertié A. Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells. PLoS ONE. 2019;14:e0204784 pubmed publisher

Zhang H, Brown R, Wei Y, Zhao P, Liu S, Liu X, et al. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019;33:166-179 pubmed publisher

D Arcy B, Swingle M, Papke C, Abney K, Bouska E, Prakash A, et al. The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C. Mol Cancer Ther. 2019;18:556-566 pubmed publisher

Anuj -, Arivazhagan L, Venkatraman G, Rayala S. Increased Expression of MicroRNA 551a by c-Fos Reduces Focal Adhesion Kinase Levels and Blocks Tumorigenesis. Mol Cell Biol. 2019;39: pubmed publisher

Zhang J, Xu X, Liu Y, Zhang L, Odle J, Lin X, et al. EPA and DHA Inhibit Myogenesis and Downregulate the Expression of Muscle-related Genes in C2C12 Myoblasts. Genes (Basel). 2019;10: pubmed publisher

Cheng W, Tsui Y, Ragusa S, Koelzer V, Mina M, Franco F, et al. Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle. Nat Immunol. 2019;20:206-217 pubmed publisher

Tse C, Yin J, Singh V, Sarker R, Lin R, Verkman A, et al. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Cell Mol Gastroenterol Hepatol. 2019;7:641-653 pubmed publisher

Maciąg F, Majewski Ł, Boguszewski P, Gupta R, Wasilewska I, Wojtas B, et al. Behavioral and electrophysiological changes in female mice overexpressing ORAI1 in neurons. Biochim Biophys Acta Mol Cell Res. 2019;1866:1137-1150 pubmed publisher

Seoane M, Buhs S, Iglesias P, Strauss J, Puller A, Muller J, et al. Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair. Oncogene. 2019;38:3616-3635 pubmed publisher

Rochel N, Krucker C, Coutos Thévenot L, Osz J, Zhang R, Guyon E, et al. Recurrent activating mutations of PPARγ associated with luminal bladder tumors. Nat Commun. 2019;10:253 pubmed publisher

Garza Morales R, Perez Trujillo J, Martinez Jaramillo E, Saucedo Cardenas O, Loera Arias M, Garcia Garcia A, et al. A DNA Vaccine Encoding SA-4-1BBL Fused to HPV-16 E7 Antigen Has Prophylactic and Therapeutic Efficacy in a Cervical Cancer Mouse Model. Cancers (Basel). 2019;11: pubmed publisher

Xiao G, Liu Z, Zhao M, Wang H, Zhou B. Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster. Cell Rep. 2019;26:748-758.e5 pubmed publisher

Paonessa F, Evans L, Solanki R, Larrieu D, Wray S, Hardy J, et al. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia. Cell Rep. 2019;26:582-593.e5 pubmed publisher

Mahmoud M, Evans I, Mehta V, Pellet Many C, Paliashvili K, Zachary I. Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation. Am J Physiol Cell Physiol. 2019;316:C424-C433 pubmed publisher

Abdollahi Govar A, Töro G, Szaniszlo P, Pavlidou A, Bibli S, Thanki K, et al. 3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. Br J Pharmacol. 2019;: pubmed publisher

Coa L, Abreu T, Tashima A, Green J, Pascon R, Vallim M, et al. AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells. Biosci Rep. 2019;39: pubmed publisher

Lopez Pastor A, Gómez Hernández A, Diaz Castroverde S, Gonzalez Aseguinolaza G, Gonzalez Rodriguez A, García G, et al. Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity. Dis Model Mech. 2019;12: pubmed publisher

Wang X, Wang W, Wang L, Yu C, Zhang G, Zhu H, et al. Lentinan modulates intestinal microbiota and enhances barrier integrity in a piglet model challenged with lipopolysaccharide. Food Funct. 2019;10:479-489 pubmed publisher

Liu Q, Wang G, Li Q, Jiang W, Kim J, Wang R, et al. Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer. Int J Cancer. 2019;145:415-426 pubmed publisher

Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, et al. USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation. J Virol. 2019;93: pubmed publisher

Fenton R, Murali S, Kaji I, Akiba Y, Kaunitz J, Kristensen T, et al. Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea. J Infect Dis. 2019;220:1719-1728 pubmed publisher

Stifter K, Schuster C, Krieger J, Spyrantis A, Boehm B, Schirmbeck R. Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination. Mol Ther Methods Clin Dev. 2019;12:123-133 pubmed publisher

Luo L, Matthews J, Robinson B, Jones R. Vibrio parahaemolyticus VopA Is a Potent Inhibitor of Cell Migration and Apoptosis in the Intestinal Epithelium of Drosophila melanogaster. Infect Immun. 2019;87: pubmed publisher

Kajimoto T, Caliman A, Tobias I, Okada T, Pilo C, Van A, et al. Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter. Sci Signal. 2019;12: pubmed publisher

Ravichandran S, Finlin B, Kern P, Ozcan S. Sphk2-/- mice are protected from obesity and insulin resistance. Biochim Biophys Acta Mol Basis Dis. 2019;1865:570-576 pubmed publisher

Festa B, Berquez M, Gassama A, Amrein I, Ismail H, Samardzija M, et al. OCRL deficiency impairs endolysosomal function in a humanized mouse model for Lowe syndrome and Dent disease. Hum Mol Genet. 2019;28:1931-1946 pubmed publisher

Yang F, Takagaki Y, Yoshitomi Y, Ikeda T, Li J, Kitada M, et al. Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis. Cancer Res. 2019;79:735-746 pubmed publisher

Kim J, Lee D, Jeong S, Kim B, Na Y, Park S, et al. Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress. Oncol Rep. 2019;41:1616-1626 pubmed publisher

Ding Y, Xu H, Li L, Yuan Y, Xu Y. Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription. Biochem Biophys Res Commun. 2019;509:633-640 pubmed publisher

Beizaei K, Gleißner L, Hoffer K, Bußmann L, Vu A, Steinmeister L, et al. Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC. Head Neck. 2019;41:208-215 pubmed publisher

Protopsaltis N, Liang W, Nudleman E, Ferrara N. Interleukin-22 promotes tumor angiogenesis. Angiogenesis. 2019;22:311-323 pubmed publisher

Neel D, Allegakoen D, Olivas V, Mayekar M, Hemmati G, Chatterjee N, et al. Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019;79:546-556 pubmed publisher

Gabandé Rodríguez E, Pérez Cañamás A, Soto Huelin B, Mitroi D, Sánchez Redondo S, Martínez Sáez E, et al. Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders. EMBO J. 2019;38: pubmed publisher

Ma Q, Gu L, Liao S, Zheng Y, Zhang S, Cao Y, et al. NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo. Apoptosis. 2019;24:83-94 pubmed publisher

Sharp C, Doll M, Dupre T, Beverly L, Siskind L. Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration. Am J Physiol Renal Physiol. 2019;316:F162-F172 pubmed publisher

Jingushi K, Uemura M, Nakano K, Hayashi Y, Wang C, Ishizuya Y, et al. Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC. Oncol Rep. 2019;41:1293-1303 pubmed publisher

Nazim U, Park S. Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS. Int J Mol Med. 2019;43:701-708 pubmed publisher

Shen J, Zhao W, Ju Z, Wang L, Peng Y, Labrie M, et al. PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness. Cancer Res. 2019;79:311-319 pubmed publisher

Mizoguchi T, Shimazawa M, Ohuchi K, Kuse Y, Nakamura S, Hara H. Impaired Cerebellar Development in Mice Overexpressing VGF. Neurochem Res. 2019;44:374-387 pubmed publisher

Wang G, Ding L, Gao C, Zhang N, Gan D, Sun Y, et al. Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice. Neuropharmacology. 2019;146:39-49 pubmed publisher

Deshar R, Yoo W, Cho E, Kim S, Yoon J. RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling. Nucleic Acids Res. 2019;47:762-778 pubmed publisher

Jiao W, Ji J, Li F, Guo J, Zheng Y, Li S, et al. Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells. Mol Med Rep. 2019;19:667-677 pubmed publisher

Doroszko M, Chruściel M, Stelmaszewska J, Ślężak T, Anisimowicz S, Plockinger U, et al. GnRH antagonist treatment of malignant adrenocortical tumors. Endocr Relat Cancer. 2019;26:103-117 pubmed publisher

Dudiki T, Joudeh N, Sinha N, Goswami S, Eisa A, Kline D, et al. The protein phosphatase isoform PP1γ1 substitutes for PP1γ2 to support spermatogenesis but not normal sperm function and fertility†. Biol Reprod. 2019;100:721-736 pubmed publisher

Jin J, Jin J, Woodfield S, Patel R, Jin N, Shi Y, et al. Targeting LRH‑1 in hepatoblastoma cell lines causes decreased proliferation. Oncol Rep. 2019;41:143-153 pubmed publisher

Lampasona A, Czaplinski K. Hnrnpab regulates neural cell motility through transcription of Eps8. RNA. 2019;25:45-59 pubmed publisher

Krishnamoorthy G, Davidson N, Leach S, Zhao Z, Lowe S, Lee G, et al. EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. Cancer Discov. 2019;9:264-281 pubmed publisher

Romano N, Veronese M, Manfrini N, Zolla L, Ceci M. Ribosomal RACK1 promotes proliferation of neuroblastoma cells independently of global translation upregulation. Cell Signal. 2019;53:102-110 pubmed publisher

Biernacki M, Ambrożewicz E, Gęgotek A, Toczek M, Skrzydlewska E. Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism. Adv Med Sci. 2019;64:15-23 pubmed publisher

Manca S, Frisbie C, Lagrange C, Casey C, Riethoven J, Petrosyan A. The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer. Mol Cancer Res. 2019;17:225-237 pubmed publisher

Ramirez V, van Oeffelen W, Torres Fuentes C, Chruscicka B, Druelle C, Golubeva A, et al. Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists. FASEB J. 2019;33:518-531 pubmed publisher

Deb B, Hasan G. SEPT7-mediated regulation of Ca2+ entry through Orai channels requires other septin subunits. Cytoskeleton (Hoboken). 2019;76:104-114 pubmed publisher

Takimoto Shimomura T, Tsukamoto T, Maegawa S, Fujibayashi Y, Matsumura Kimoto Y, Mizuno Y, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2019;37:210-222 pubmed publisher

Rigalli J, Scholz P, Tocchetti G, Ruiz M, Weiss J. The phytoestrogens daidzein and equol inhibit the drug transporter BCRP/ABCG2 in breast cancer cells: potential chemosensitizing effect. Eur J Nutr. 2019;58:139-150 pubmed publisher

Sharma R, Williams I, Gatchie L, Sonawane V, Chaudhuri B, Bharate S. Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1. ACS Omega. 2018;3:8553-8566 pubmed publisher

Kubyshkin A, Fomochkina I, Petrosyan A. THE IMPACT OF ALCOHOL ON PRO-METASTATIC N-GLYCOSYLATION IN PROSTATE CANCER. Krim Z Eksp Klin Med. 2018;8:11-20 pubmed

Pozo K, Zahler S, Ishimatsu K, Carter A, Telange R, Tan C, et al. Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer. Oncotarget. 2018;9:37662-37675 pubmed publisher

Tyagi M, Cheema M, Dryhurst D, Eskiw C, Ausio J. Metformin alters H2A.Z dynamics and regulates androgen dependent prostate cancer progression. Oncotarget. 2018;9:37054-37068 pubmed publisher

Tsai S, Chang C, Yong S, Lim A, Nakao Y, Chen S, et al. A Hydrolyzed Chicken Extract CMI-168 Enhances Learning and Memory in Middle-Aged Mice. Nutrients. 2018;11: pubmed publisher

Leguina Ruzzi A, Ortiz R, Velarde V. The streptozotocin-high fat diet induced diabetic mouse model exhibits severe skin damage and alterations in local lipid mediators. Biomed J. 2018;41:328-332 pubmed publisher

Huang Y, Chiang M, Ho C, Hung P, Hsu M, Lee T, et al. A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder. Aging Dis. 2018;9:1043-1057 pubmed publisher

Petõvári G, Hujber Z, Krencz I, Dankó T, Nagy N, Tóth F, et al. Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells. Cancer Cell Int. 2018;18:211 pubmed publisher

Kostić M, Katoshevski T, Sekler I. Allosteric Regulation of NCLX by Mitochondrial Membrane Potential Links the Metabolic State and Ca2+ Signaling in Mitochondria. Cell Rep. 2018;25:3465-3475.e4 pubmed publisher

Kameyama T, Ohuchi K, Funato M, Ando S, Inagaki S, Sato A, et al. Efficacy of Prednisolone in Generated Myotubes Derived From Fibroblasts of Duchenne Muscular Dystrophy Patients. Front Pharmacol. 2018;9:1402 pubmed publisher

Naito R, Kassai H, Sakai Y, Schönherr S, Fukaya M, Schwarzer C, et al. New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines. Front Mol Neurosci. 2018;11:439 pubmed publisher

Perra L, Balloy V, Foussignière T, Moissenet D, Petat H, Mungrue I, et al. CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa. Front Immunol. 2018;9:2823 pubmed publisher

Ceccon M, Mauri M, Massimino L, Giudici G, Piazza R, Gambacorti Passerini C, et al. Mitochondrial Hyperactivation and Enhanced ROS Production are Involved in Toxicity Induced by Oncogenic Kinases Over-Signaling. Cancers (Basel). 2018;10: pubmed publisher

Ibrahim M, Klement J, Lu C, Redd P, Xiao W, Yang D, et al. Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis. Cell Rep. 2018;25:3036-3046.e6 pubmed publisher

Tailler M, Lindqvist L, Gibson L, Adams J. By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737. Cell Death Differ. 2018;: pubmed publisher

Li X, Lin Z, Wang L, Liu Q, Cao Z, Huang Z, et al. RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis. Cell Physiol Biochem. 2018;51:2198-2211 pubmed publisher

He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, et al. Binding of HMGN proteins to cell specific enhancers stabilizes cell identity. Nat Commun. 2018;9:5240 pubmed publisher

Gomes A, Kurochkin I, Chang B, DANIEL M, Law K, Satija N, et al. Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming. Cell Rep. 2018;25:2821-2835.e7 pubmed publisher

Vargas Mendoza N, Vázquez Velasco M, González Torres L, Benedi J, Sánchez Muniz F, Morales González J, et al. Effect of Extract and Ellagic Acid from Geranium schiedeanum on the Antioxidant Defense System in An Induced-Necrosis Model. Antioxidants (Basel). 2018;7: pubmed publisher

Vanhauwaert S, Decaesteker B, De Brouwer S, Leonelli C, Durinck K, Mestdagh P, et al. In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors. Sci Rep. 2018;8:17468 pubmed publisher

Lee S, Cieply B, Yang Y, Peart N, Glaser C, Chan P, et al. Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity. Cell Rep. 2018;25:2417-2430.e5 pubmed publisher

Zhang L, Wang X, Chen S, Wang S, Tu Z, Zhang G, et al. Medium-Chain Triglycerides Attenuate Liver Injury in Lipopolysaccharide-Challenged Pigs by Inhibiting Necroptotic and Inflammatory Signaling Pathways. Int J Mol Sci. 2018;19: pubmed publisher

Decaesteker B, Denecker G, Van Neste C, Dolman E, Van Loocke W, Gartlgruber M, et al. TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets. Nat Commun. 2018;9:4866 pubmed publisher

Chang B, Meng J, Zhu H, Du X, Sun L, Wang L, et al. Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma. Diagn Pathol. 2018;13:87 pubmed publisher

Shashi V, Magiera M, Klein D, Zaki M, Schoch K, Rudnik Schoneborn S, et al. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. EMBO J. 2018;37: pubmed publisher

Chang H, Valieva M, Safina A, Chereji R, Wang J, Kulaeva O, et al. Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins. Sci Adv. 2018;4:eaav2131 pubmed publisher

Wettmarshausen J, Goh V, Huang K, Arduino D, Tripathi U, Leimpek A, et al. MICU1 Confers Protection from MCU-Dependent Manganese Toxicity. Cell Rep. 2018;25:1425-1435.e7 pubmed publisher

Schipp C, Schlütermann D, Hönscheid A, Nabhani S, Höll J, Oommen P, et al. EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency. Front Immunol. 2018;9:2400 pubmed publisher

Sokolova M, Moore H, Prajapati B, Dopie J, Meriläinen L, Honkanen M, et al. Nuclear Actin Is Required for Transcription during Drosophila Oogenesis. iScience. 2018;9:63-70 pubmed publisher

Yuan J, Ng W, Tian Z, Yap J, Baccarini M, Chen Z, et al. Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis. Sci Signal. 2018;11: pubmed publisher

Gomez A, Bindesbøll C, Satheesh S, Grimaldi G, Hutin D, MacPherson L, et al. Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity. Biochem J. 2018;475:3827-3846 pubmed publisher

Torgovnick A, Heger J, Liaki V, Isensee J, Schmitt A, Knittel G, et al. The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Rep. 2018;25:1027-1039.e6 pubmed publisher

Ivanyi Nagy R, Ahmed S, Peter S, Ramani P, Ong P, Dreesen O, et al. The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis. elife. 2018;7: pubmed publisher

Dhingra A, Bell B, Peachey N, Daniele L, Reyes Reveles J, Sharp R, et al. Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci. 2018;12:351 pubmed publisher

Zhao N, Liu C, Van Ingelgom A, Linares C, Kurti A, Knight J, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nat Commun. 2018;9:4388 pubmed publisher

Hawer H, Ütkür K, Arend M, Mayer K, Adrian L, Brinkmann U, et al. Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast. PLoS ONE. 2018;13:e0205870 pubmed publisher

Kim H, Kim D, Bae S, Gwak H, Jeon J, Kim J, et al. Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Exp Mol Med. 2018;50:137 pubmed publisher

Gao Y, Kardos J, Yang Y, Tamir T, Mutter Rottmayer E, Weissman B, et al. The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells. Sci Rep. 2018;8:15304 pubmed publisher

Murata H, Khine C, Nishikawa A, Yamamoto K, Kinoshita R, Sakaguchi M. c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration. J Biol Chem. 2018;293:18933-18943 pubmed publisher

Ooki A, Vandenbussche C, Kates M, Hahn N, Matoso A, McConkey D, et al. CD24 regulates cancer stem cell (CSC)-like traits and a panel of CSC-related molecules serves as a non-invasive urinary biomarker for the detection of bladder cancer. Br J Cancer. 2018;119:961-970 pubmed publisher

Xia L, Wu J, Pattaradilokrat S, Tumas K, He X, Peng Y, et al. Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention. Sci Rep. 2018;8:15280 pubmed publisher

Madeo M, Colbert P, Vermeer D, Lucido C, Cain J, Vichaya E, et al. Cancer exosomes induce tumor innervation. Nat Commun. 2018;9:4284 pubmed publisher

Lehrman E, Wilton D, Litvina E, Welsh C, Chang S, Frouin A, et al. CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron. 2018;100:120-134.e6 pubmed publisher

Timper K, Paeger L, Sánchez Lasheras C, Varela L, Jais A, Nolte H, et al. Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. 2018;25:383-397.e10 pubmed publisher

Fets L, Driscoll P, Grimm F, Jain A, Nunes P, Gounis M, et al. MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG. Nat Chem Biol. 2018;14:1032-1042 pubmed publisher

Huo J, Chen X, Zhang H, Hu Y, Jiang Y, Liu S, et al. Bcl-3 promotes proliferation and chemosensitivity in BL1 subtype of TNBC cells. Acta Biochim Biophys Sin (Shanghai). 2018;50:1141-1149 pubmed publisher

Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, et al. Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity. J Virol. 2018;92: pubmed publisher

Rodrigues M, Miguita L, de Andrade N, Heguedusch D, Rodini C, Moyses R, et al. GLI3 knockdown decreases stemness, cell proliferation and invasion in oral squamous cell carcinoma. Int J Oncol. 2018;53:2458-2472 pubmed publisher

Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, et al. Infection with flaviviruses requires BCLXL for cell survival. PLoS Pathog. 2018;14:e1007299 pubmed publisher

Jiang K, Tang Z, Li J, Wang F, Tang N. Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification. Sci Rep. 2018;8:14344 pubmed publisher

Shen Q, Li J, Mai J, Zhang Z, Fisher A, Wu X, et al. Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis. Cell Death Dis. 2018;9:986 pubmed publisher

Dai J, Zhou Q, Chen J, Rexius Hall M, Rehman J, Zhou G. Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway. Nat Commun. 2018;9:3850 pubmed publisher

Nerlakanti N, Yao J, Nguyen D, Patel A, Eroshkin A, Lawrence H, et al. Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2018;17:2796-2810 pubmed publisher

Chatterjee A, Rodger E, Ahn A, Stockwell P, Parry M, Motwani J, et al. Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma. iScience. 2018;4:312-325 pubmed publisher

Bydoun M, Sterea A, Weaver I, Bharadwaj A, Waisman D. A novel mechanism of plasminogen activation in epithelial and mesenchymal cells. Sci Rep. 2018;8:14091 pubmed publisher

Banerjee K, Pru C, Pru J, Resat H. STAT3 Knockdown Induces Tumor Formation by MDA-MB-231 Cells. Clin Oncol Res. 2018;1: pubmed publisher

Zhang P, He F, Bai J, Yamamoto S, Chen S, Zhang L, et al. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. J Clin Invest. 2018;128:5383-5398 pubmed publisher

Su B, Xu T, Bruce J, Yip K, Zhang N, Huang Z, et al. hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis. Oncol Rep. 2018;40:2536-2546 pubmed publisher

Mittenbühler M, Sprenger H, Gruber S, Wunderlich C, Kern L, Bruning J, et al. Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma. Mol Metab. 2018;17:122-133 pubmed publisher

Biernacki M, Łuczaj W, Jarocka Karpowicz I, Ambrożewicz E, Toczek M, Skrzydlewska E. The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension. Molecules. 2018;23: pubmed publisher

Chua P, Lim J, Guo T, Khanna P, Hu Q, Bay B, et al. Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells. Int J Oncol. 2018;53:2579-2589 pubmed publisher

Zelinka C, Sotolongo Lopez M, Fadool J. Targeted disruption of the endogenous zebrafish rhodopsin locus as models of rapid rod photoreceptor degeneration. Mol Vis. 2018;24:587-602 pubmed

Suyama K, Sakai D, Hirayama N, Nakamura Y, Matsushita E, Terayama H, et al. Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease. J Cell Mol Med. 2018;22:5539-5551 pubmed publisher

Dunphy G, Flannery S, Almine J, Connolly D, Paulus C, Jønsson K, et al. Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage. Mol Cell. 2018;71:745-760.e5 pubmed publisher

Yan X, Shen H, Jiang H, Hu D, Wang J, Wu X. YXQ-EQ Induces Apoptosis and Inhibits Signaling Pathways Important for Metastasis in Non-Small Cell Lung Carcinoma Cells. Cell Physiol Biochem. 2018;49:911-919 pubmed publisher

Awasthi S, Chakrapani B, Mahesh A, Chavali P, Chavali S, Dhayalan A. DDX39B promotes translation through regulation of pre-ribosomal RNA levels. RNA Biol. 2018;15:1157-1166 pubmed publisher

Gammage P, Minczuk M. Enhanced Manipulation of Human Mitochondrial DNA Heteroplasmy In Vitro Using Tunable mtZFN Technology. Methods Mol Biol. 2018;1867:43-56 pubmed publisher

Mochizuki Y, Chiba T, Kataoka K, Yamashita S, Sato T, Kato T, et al. Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression. Dev Cell. 2018;46:794-806.e6 pubmed publisher

Lian H, Wei J, Zang R, Ye W, Yang Q, Zhang X, et al. ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. Nat Commun. 2018;9:3349 pubmed publisher

Duggimpudi S, Kloetgen A, Maney S, Münch P, Hezaveh K, Shaykhalishahi H, et al. Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling. J Biol Chem. 2018;293:15359-15369 pubmed publisher

Corigliano D, Syed R, Messineo S, Lupia A, Patel R, Reddy C, et al. Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators. Peerj. 2018;6:e5386 pubmed publisher

Cha J, Yang W, Xia W, Wei Y, Chan L, Lim S, et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Mol Cell. 2018;71:606-620.e7 pubmed publisher

Parras A, Anta H, Santos Galindo M, Swarup V, Elorza A, Nieto González J, et al. Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature. 2018;560:441-446 pubmed publisher

Zuena A, Iacovelli L, Orlando R, Di Menna L, Casolini P, Alemà G, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018;9:804 pubmed publisher

Oh S, Park H, He L, Skibiel C, Junn E, Mouradian M. The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress. Redox Biol. 2018;19:62-73 pubmed publisher

Vasarmidi E, Sarantoulaki S, Trachalaki A, Margaritopoulos G, Bibaki E, Spandidos D, et al. Investigation of key autophagy-and mitophagy-related proteins and gene expression in BALF cells from patients with IPF and RA-ILD. Mol Med Rep. 2018;18:3891-3897 pubmed publisher

Nuno D, Coppey L, Yorek M, Lamping K. Dietary fats modify vascular fat composition, eNOS localization within lipid rafts and vascular function in obesity. Physiol Rep. 2018;6:e13820 pubmed publisher

Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, et al. C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation. Front Immunol. 2018;9:1604 pubmed publisher

Chen Q, Kassab M, Dantzer F, Yu X. PARP2 mediates branched poly ADP-ribosylation in response to DNA damage. Nat Commun. 2018;9:3233 pubmed publisher

Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, et al. Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. J Cell Biol. 2018;217:3817-3828 pubmed publisher

Dai J, Zhou Q, Tang H, Chen T, Li J, Raychaudhuri P, et al. Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension. Cell Signal. 2018;51:119-129 pubmed publisher

Yu X, Lao Y, Teng X, Li S, Zhou Y, Wang F, et al. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 2018;9:3157 pubmed publisher

D Antoni M, Mitchell B, McCurdy S, Byron M, Ogata Arakaki D, Chow D, et al. Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression. J Leukoc Biol. 2018;104:1241-1252 pubmed publisher

Wu G, Xu G, Chen D, Gao W, Xiong J, Shen H, et al. Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway. Front Immunol. 2018;9:1667 pubmed publisher

Zhu G, Zhou L, Liu H, Shan Y, Zhang X. MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway. Cell Physiol Biochem. 2018;48:1735-1746 pubmed publisher

Campbell P, Mavingire N, Khan S, Rowland L, Wooten J, Opoku Agyeman A, et al. AhR ligand aminoflavone suppresses α6-integrin-Src-Akt signaling to attenuate tamoxifen resistance in breast cancer cells. J Cell Physiol. 2018;234:108-121 pubmed publisher

Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, et al. Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer. Clin Cancer Res. 2018;24:5744-5756 pubmed publisher

Liu M, Shi R, Hwang H, Han K, Wong M, Ren X, et al. SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. J Neurophysiol. 2018;120:1578-1586 pubmed publisher

Li Z, Chen B, Dong W, Xu W, Song M, Fang M, et al. Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells. Biochim Biophys Acta Gene Regul Mech. 2018;: pubmed publisher

Bhogal R, Weston C, Velduis S, G D Leuvenink H, Reynolds G, Davies S, et al. The Reactive Oxygen Species-Mitophagy Signaling Pathway Regulates Liver Endothelial Cell Survival During Ischemia/Reperfusion Injury. Liver Transpl. 2018;24:1437-1452 pubmed publisher

Soma S, Latimer A, Chun H, Vicary A, Timbalia S, Boulet A, et al. Elesclomol restores mitochondrial function in genetic models of copper deficiency. Proc Natl Acad Sci U S A. 2018;115:8161-8166 pubmed publisher

Van Ly D, Low R, Frölich S, Bartolec T, Kafer G, Pickett H, et al. Telomere Loop Dynamics in Chromosome End Protection. Mol Cell. 2018;71:510-525.e6 pubmed publisher

Singh V, Yang J, Yin J, Cole R, Tse M, Berman D, et al. Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane. J Cell Sci. 2018;131: pubmed publisher

Meddeb W, Rezig L, Zarrouk A, Nury T, Vejux A, Prost M, et al. Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes. Antioxidants (Basel). 2018;7: pubmed publisher

Doria J, de Souza J, Silva F, Olmo I, Carvalho T, Alves Silva J, et al. The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington's disease. J Neurochem. 2018;147:222-239 pubmed publisher

Wang C, Tan Z, Niu B, Tsang K, Tai A, Chan W, et al. Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia. elife. 2018;7: pubmed publisher

Mandal P, Feng Y, Lyons J, Berger S, Otani S, DeLaney A, et al. Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Immunity. 2018;49:42-55.e6 pubmed publisher

Ramachandran D, Clara R, Fedele S, Michel L, Burkard J, KAUFMAN S, et al. Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat. Sci Rep. 2018;8:10818 pubmed publisher

Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, et al. ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage. Nat Commun. 2018;9:2736 pubmed publisher

Ke X, Johnson H, Jing X, Michalkiewicz T, Huang Y, Lane R, et al. Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model. Physiol Genomics. 2018;50:828-836 pubmed publisher

Ma J, Chang K, Peng J, Shi Q, Gan H, Gao K, et al. SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression. J Exp Clin Cancer Res. 2018;37:145 pubmed publisher

Knauf J, Luckett K, Chen K, Voza F, Socci N, Ghossein R, et al. Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers. J Clin Invest. 2018;128:4086-4097 pubmed publisher

Pakravan G, Foroughmand A, Peymani M, Ghaedi K, Hashemi M, Hajjari M, et al. Downregulation of miR-130a, antagonized doxorubicin-induced cardiotoxicity via increasing the PPAR? expression in mESCs-derived cardiac cells. Cell Death Dis. 2018;9:758 pubmed publisher

Xu X, Wang X, Wu H, Zhu H, Liu C, Hou Y, et al. Glycine Relieves Intestinal Injury by Maintaining mTOR Signaling and Suppressing AMPK, TLR4, and NOD Signaling in Weaned Piglets after Lipopolysaccharide Challenge. Int J Mol Sci. 2018;19: pubmed publisher

Gaffney Stomberg E, Marszewski P, MacArthur M, McClung J, Matheny R. Paracellular calcium flux across Caco-2 cell monolayers: Effects of individual amino acids. J Nutr Biochem. 2018;59:114-122 pubmed publisher

Liang Y, Pan B, Alam H, Deng Q, Wang Y, Chen E, et al. Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia. Eur J Pharmacol. 2018;833:432-440 pubmed publisher

Ooki A, Dinalankara W, Marchionni L, Tsay J, Goparaju C, Maleki Z, et al. Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma. Oncogene. 2018;37:5967-5981 pubmed publisher

Cui Y, Kim H, Lee M, Yi J, Kim R, Uddin N, et al. FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation. Oncogene. 2018;37:5794-5809 pubmed publisher

Heise C, Preuss J, Schroeder J, Battaglia C, Kolibius J, Schmid R, et al. Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models. Front Mol Neurosci. 2018;11:212 pubmed publisher

Arias Alvarez M, Garcia Garcia R, López Tello J, Rebollar P, Gutierrez Adan A, Lorenzo P. α-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during in vitro maturation and enhances the developmental competence of rabbit oocytes. Reprod Fertil Dev. 2018;30:1728-1738 pubmed publisher

Rastogi S, Haldar C. Comparative effect of melatonin and quercetin in counteracting LPS induced oxidative stress in bone marrow mononuclear cells and spleen of Funambulus pennanti. Food Chem Toxicol. 2018;120:243-252 pubmed publisher

Urick M, Bell D. In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased levels of potentially druggable proteins and sensitivity to SI-2 and dinaciclib. Mol Carcinog. 2018;57:1445-1457 pubmed publisher

Jarvela T, Womack T, Georgiou P, Gould T, Eriksen J, Lindberg I. 7B2 chaperone knockout in APP model mice results in reduced plaque burden. Sci Rep. 2018;8:9813 pubmed publisher

Drummond M, Li M, Tarapore E, Nguyen T, Barouni B, Cruz S, et al. Actin polymerization controls cilia-mediated signaling. J Cell Biol. 2018;217:3255-3266 pubmed publisher

Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y, Kataoka H, et al. HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles. Sci Rep. 2018;8:9601 pubmed publisher

da Silva R, Dhar D, Raina K, Kumar D, Kant R, Cagnon V, et al. Nintedanib inhibits growth of human prostate carcinoma cells by modulating both cell cycle and angiogenesis regulators. Sci Rep. 2018;8:9540 pubmed publisher

Khanna P, Lee J, Sereemaspun A, Lee H, Baeg G. GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling. Sci Rep. 2018;8:9511 pubmed publisher

Xie C, Cai X, Wang X, Lin L, Long Y, Cui X. Gene expression profiles of HTR8-S/Vneo cells after changes in ABCA1 expression. Funct Integr Genomics. 2018;18:725-735 pubmed publisher

Yuan J, Ng W, Lam P, Wang Y, Xia H, Yap J, et al. The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants. Oncogene. 2018;37:5719-5734 pubmed publisher

Aki D, Li H, Zhang W, Zheng M, Elly C, Lee J, et al. The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR. Nat Immunol. 2018;19:766-775 pubmed publisher

Dai Z, Zhu M, Peng Y, Machireddy N, Evans C, Machado R, et al. Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor. Am J Respir Crit Care Med. 2018;198:1423-1434 pubmed publisher

Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, et al. Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1β via CD36 and Nicotinic Acetylcholine Receptors. Front Immunol. 2018;9:877 pubmed publisher

Tchoukaev A, Taytard J, Rousselet N, Rebeyrol C, Debray D, Blouquit Laye S, et al. Opposite Expression of Hepatic and Pulmonary Corticosteroid-Binding Globulin in Cystic Fibrosis Patients. Front Pharmacol. 2018;9:545 pubmed publisher

Sasaki Y, Hackett A, Kim S, Strickland A, Milbrandt J. Dysregulation of NAD+ Metabolism Induces a Schwann Cell Dedifferentiation Program. J Neurosci. 2018;38:6546-6562 pubmed publisher

Jung S, Son H, Hwang C, Cho K, Park S, Kim H. Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver. J Clin Med. 2018;7: pubmed publisher

Dompe N, Klijn C, Watson S, Leng K, Port J, Cuellar T, et al. A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC. PLoS ONE. 2018;13:e0199264 pubmed publisher

Studentsova V, Mora K, Glasner M, Buckley M, Loiselle A. Obesity/Type II Diabetes Promotes Function-limiting Changes in Murine Tendons that are not reversed by Restoring Normal Metabolic Function. Sci Rep. 2018;8:9218 pubmed publisher

Kim S, Knight D, Jones L, Vervoort S, Ng A, Seymour J, et al. JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias. Genes Dev. 2018;32:849-864 pubmed publisher

Li F, Zhang B, Cui J, Chen F, Ding Y, Feng X. Alterations in β‑catenin/E‑cadherin complex formation during the mechanotransduction of Saos‑2 osteoblastic cells. Mol Med Rep. 2018;18:1495-1503 pubmed publisher

Abaandou L, Shiloach J. Knocking out Ornithine Decarboxylase Antizyme 1 (OAZ1) Improves Recombinant Protein Expression in the HEK293 Cell Line. Med Sci (Basel). 2018;6: pubmed publisher

Kerov V, Laird J, Joiner M, Knecht S, Soh D, Hagen J, et al. α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses. J Neurosci. 2018;38:6145-6160 pubmed publisher

Yu M, Liu T, Chen Y, Li Y, Li W. Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy. J Exp Clin Cancer Res. 2018;37:114 pubmed publisher

Zhu Q, Hoong N, Aslanian A, Hara T, Benner C, Heinz S, et al. Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer. Mol Cell. 2018;70:842-853.e7 pubmed publisher

Zhou H, Ni Z, Li T, Su L, Zhang L, Liu N, et al. Activation of FXR promotes intestinal metaplasia of gastric cells via SHP-dependent upregulation of the expression of CDX2. Oncol Lett. 2018;15:7617-7624 pubmed publisher

Minaidou A, Nicolaou P, Christodoulou K. LRSAM1 Depletion Affects Neuroblastoma SH-SY5Y Cell Growth and Morphology: The LRSAM1 c.2047-1G>A Loss-of-Function Variant Fails to Rescue The Phenotype. Cell J. 2018;20:340-347 pubmed publisher

Wang X, Gray Z, Willette Brown J, Zhu F, Shi G, Jiang Q, et al. Macrophage inducible nitric oxide synthase circulates inflammation and promotes lung carcinogenesis. Cell Death Discov. 2018;4:46 pubmed publisher

Callender J, Yang Y, Lordén G, Stephenson N, Jones A, Brognard J, et al. Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proc Natl Acad Sci U S A. 2018;115:E5497-E5505 pubmed publisher

Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed publisher

Yang W, Cha J, Xia W, Lee H, Chan L, Wang Y, et al. Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression. Cancer Res. 2018;78:3761-3768 pubmed publisher

Stuhlmann T, Planells Cases R, Jentsch T. LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion. Nat Commun. 2018;9:1974 pubmed publisher

Dedoni S, CAMPBELL L, Harvey B, Avdoshina V, Mocchetti I. The orphan G-protein-coupled receptor 75 signaling is activated by the chemokine CCL5. J Neurochem. 2018;146:526-539 pubmed publisher

Lu X, Pan X, Wu C, Zhao D, Feng S, Zang Y, et al. An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. Cancer Res. 2018;78:3823-3833 pubmed publisher

Untch B, Dos Anjos V, Garcia Rendueles M, Knauf J, Krishnamoorthy G, Saqcena M, et al. Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers. Cancer Res. 2018;78:4642-4657 pubmed publisher

Mota R, Parry T, Yates C, Qiang Z, Eaton S, Mwiza J, et al. Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo. Am J Pathol. 2018;188:1676-1692 pubmed publisher

Di Rita A, D Acunzo P, Simula L, Campello S, Strappazzon F, Cecconi F. AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells. Front Cell Neurosci. 2018;12:92 pubmed publisher

Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, et al. The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity. Immunity. 2018;48:979-991.e8 pubmed publisher

Shukla R, Banerjee S, Tripathi Y. Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complement Altern Med. 2018;18:156 pubmed publisher

Jaiswal P, Koul S, Shanmugam P, Koul H. Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis. Sci Rep. 2018;8:7459 pubmed publisher

Paradis Isler N, Boehm J. NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation. J Biol Chem. 2018;293:9311-9325 pubmed publisher

Brandt L, Albers J, Hejhal T, Pfundstein S, Gonçalves A, Catalano A, et al. Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Oncotarget. 2018;9:19753-19766 pubmed publisher

Logan R, Parekh P, Kaplan G, Becker Krail D, Williams W, Yamaguchi S, et al. NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward. Mol Psychiatry. 2018;: pubmed publisher

Zhuang L, Jang Y, Park Y, Lee J, Jain S, Froimchuk E, et al. Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018;9:1796 pubmed publisher

Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, et al. Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells. Oncotarget. 2018;9:18367-18385 pubmed publisher

Koumangoye R, Omer S, Delpire E. Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells. Am J Physiol Cell Physiol. 2018;315:C258-C276 pubmed publisher

Rother M, Gonzalez E, Teixeira da Costa A, Wask L, Gravenstein I, Pardo M, et al. Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection. Cell Host Microbe. 2018;23:661-671.e8 pubmed publisher

Robichaux J, Elamin Y, Tan Z, Carter B, Zhang S, Liu S, et al. Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer. Nat Med. 2018;24:638-646 pubmed publisher

Celińska Janowicz K, Zaręba I, Lazarek U, Teul J, Tomczyk M, Pałka J, et al. Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27). Front Pharmacol. 2018;9:336 pubmed publisher

Fitzpatrick L, Hawkins K, Delhove J, Fernandez E, Soldati C, Bullen L, et al. NF-?B Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program. Stem Cell Reports. 2018;10:1766-1781 pubmed publisher

Wang C, Silverman R, Shen J, O Keefe R. Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis. J Orthop Translat. 2018;12:66-73 pubmed publisher

Cho H, Rambout X, Gleghorn M, Nguyen P, Phipps C, Miyoshi K, et al. Transcriptional coactivator PGC-1? contains a novel CBP80-binding motif that orchestrates efficient target gene expression. Genes Dev. 2018;32:555-567 pubmed publisher

Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, et al. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nat Commun. 2018;9:1411 pubmed publisher

Calegari Silva T, Vivarini Á, Pereira R, Dias Teixeira K, Rath C, Pacheco A, et al. Leishmania amazonensis downregulates macrophage iNOS expression via Histone Deacetylase 1 (HDAC1): a novel parasite evasion mechanism. Eur J Immunol. 2018;48:1188-1198 pubmed publisher

Hiller S, Heldmann S, Richter K, Jurastow I, Küllmar M, Hecker A, et al. ?-Nicotinamide Adenine Dinucleotide (?-NAD) Inhibits ATP-Dependent IL-1? Release from Human Monocytic Cells. Int J Mol Sci. 2018;19: pubmed publisher

Tung M, Tang D, Wang S, Zhan D, Kiplinger K, Pan S, et al. High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells. Biotechnol J. 2018;13:e1700746 pubmed publisher

Cho E, Yoo W, Yoon S, Yoon J. β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2199-2213 pubmed publisher

Xiong J, Pecchi V, Qui M, Ivanov A, Mo X, Niu Q, et al. Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction. Assay Drug Dev Technol. 2018;16:96-106 pubmed publisher

Wu Q, Tian Y, Zhang J, Tong X, Huang H, Li S, et al. In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis. Proc Natl Acad Sci U S A. 2018;115:E3978-E3986 pubmed publisher

Qiu C, Wang Y, Wang X, Zhang Q, Li Y, Xu Y, et al. Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade serous carcinoma. Int J Oncol. 2018;52:2041-2050 pubmed publisher

Awasthi S, Verma M, Mahesh A, K Khan M, Govindaraju G, Rajavelu A, et al. DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA. Nucleic Acids Res. 2018;46:6304-6317 pubmed publisher

Chen M, Hale C, Stanislaus S, Xu J, Véniant M. FGF21 acts as a negative regulator of bile acid synthesis. J Endocrinol. 2018;237:139-152 pubmed publisher

Habib S, El Andaloussi A, Elmasry K, Handoussa A, Azab M, Elsawey A, et al. PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani. Infect Immun. 2018;86: pubmed publisher

Arai M, Akamine R, Tsuchiya A, Yoneyama T, Koyano T, Kowithayakorn T, et al. The Notch inhibitor cowanin accelerates nicastrin degradation. Sci Rep. 2018;8:5376 pubmed publisher

Li Q, Lin L, Tong Y, Liu Y, Mou J, Wang X, et al. TRIM29 negatively controls antiviral immune response through targeting STING for degradation. Cell Discov. 2018;4:13 pubmed publisher

Wang S, Liu A, Wu G, Ding H, Huang S, Nahman S, et al. The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation. Nat Commun. 2018;9:1234 pubmed publisher

Zhang B, Niu W, Dong H, Liu M, Luo Y, Li Z. Hypoxia induces endothelial‑mesenchymal transition in pulmonary vascular remodeling. Int J Mol Med. 2018;42:270-278 pubmed publisher

Peiris Pagès M, Bonuccelli G, Sotgia F, Lisanti M. Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling. Oncotarget. 2018;9:13254-13275 pubmed publisher

Seale L, Ha H, Hashimoto A, Berry M. Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism. Free Radic Biol Med. 2018;127:182-189 pubmed publisher

Yin P, Li Y, Zhou L, Zhang L. NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3. Virol Sin. 2018;33:205-208 pubmed publisher

Garrido Gil P, Dominguez Meijide A, Moratalla R, Guerra M, Labandeira Garcia J. Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly. Oncotarget. 2018;9:10834-10846 pubmed publisher

Weng L, Han Y, Enomoto A, Kitaura Y, Nagamori S, Kanai Y, et al. Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex. PLoS Biol. 2018;16:e2005090 pubmed publisher

Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, et al. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO J. 2018;37: pubmed publisher

Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, et al. Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation. Cancer Cell. 2018;33:480-494.e7 pubmed publisher

Chhabra A, Mishra S, Kumar G, Gupta A, Keshri G, Bharti B, et al. Glucose-6-phosphate dehydrogenase is critical for suppression of cardiac hypertrophy by H2S. Cell Death Discov. 2018;4:6 pubmed publisher

Devarajan A, Su F, Grijalva V, Yalamanchi M, Yalamanchi A, Gao F, et al. Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer. Cell Death Dis. 2018;9:392 pubmed publisher

Fioramonti M, Fausti V, Pantano F, Iuliani M, Ribelli G, Lotti F, et al. Cabozantinib Affects Osteosarcoma Growth Through A Direct Effect On Tumor Cells and Modifications In Bone Microenvironment. Sci Rep. 2018;8:4177 pubmed publisher

Stefanovic Barrett S, Dickson A, Burr S, Williamson J, Lobb I, van den Boomen D, et al. MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins. EMBO Rep. 2018;19: pubmed publisher

Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher

Blum Johnston C, Thorpe R, Wee C, Opsahl R, Romero M, Murray S, et al. Long-term hypoxia uncouples Ca2+ and eNOS in bradykinin-mediated pulmonary arterial relaxation. Am J Physiol Regul Integr Comp Physiol. 2018;314:R870-R882 pubmed publisher

Zhu H, Wang H, Wang S, Tu Z, Zhang L, Wang X, et al. Flaxseed Oil Attenuates Intestinal Damage and Inflammation by Regulating Necroptosis and TLR4/NOD Signaling Pathways Following Lipopolysaccharide Challenge in a Piglet Model. Mol Nutr Food Res. 2018;62:e1700814 pubmed publisher

Tang A, Bennett W, Hadrill C, Collins J, Fulopova B, Wills K, et al. Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice. Sci Rep. 2018;8:4016 pubmed publisher

Wong K, Beirowski B. Multiple lines of inhibitory feedback on AKT kinase in Schwann cells lacking TSC1/2 hint at distinct functions of mTORC1 and AKT in nerve development. Commun Integr Biol. 2018;11:e1433441 pubmed publisher

Ciołczyk Wierzbicka D, Laidler P. The inhibition of invasion of human melanoma cells through N-cadherin knock-down. Med Oncol. 2018;35:42 pubmed publisher

Zheng Z, Fan S, Zheng J, Huang W, Gasparetto C, Chao N, et al. Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma. J Hematol Oncol. 2018;11:29 pubmed publisher

Hatcher J, Wu G, Zeng C, Zhu J, Meng F, Patel S, et al. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018;25:460-470.e6 pubmed publisher

Heidelberger J, Voigt A, Borisova M, Petrosino G, Ruf S, Wagner S, et al. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. EMBO Rep. 2018;19: pubmed publisher

Ganju A, Chauhan S, Hafeez B, Doxtater K, Tripathi M, Zafar N, et al. Protein kinase D1 regulates subcellular localisation and metastatic function of metastasis-associated protein 1. Br J Cancer. 2018;118:587-599 pubmed publisher

Mahe M, Dufour F, Neyret Kahn H, Moreno Vega A, Béraud C, Shi M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018;10: pubmed publisher

Kogiso M, Qi L, Braun F, Injac S, Zhang L, Du Y, et al. Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models. Clin Cancer Res. 2018;24:2159-2170 pubmed publisher

Domagala A, Stachura J, Gabrysiak M, Muchowicz A, Zagozdzon R, Golab J, et al. Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy. BMC Cancer. 2018;18:210 pubmed publisher

Xu H, Huang S, Zhu X, Zhang W, Zhang X. FOXK1 promotes glioblastoma proliferation and metastasis through activation of Snail transcription. Exp Ther Med. 2018;15:3108-3116 pubmed publisher

Qi Z, Xu H, Zhang S, Xu J, Li S, Gao H, et al. RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. Int J Oncol. 2018;52:1105-1116 pubmed publisher

Castellanos Esparza Y, Wu S, Huang L, Buquet C, Shen R, Sanchez Gonzalez B, et al. Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells. Int J Oncol. 2018;52:1246-1254 pubmed publisher

Kumar A, Giri S, Shaha C. Sestrin2 facilitates glutamine-dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation. FEBS J. 2018;285:1326-1345 pubmed publisher

Vighi E, Rentsch A, Henning P, Comitato A, Hoffmann D, Bertinetti D, et al. New cGMP analogues restrain proliferation and migration of melanoma cells. Oncotarget. 2018;9:5301-5320 pubmed publisher

Liu J, Quan L, Zhang C, Liu A, Tong D, Wang J. Over-activated PD-1/PD-L1 axis facilitates the chemoresistance of diffuse large B-cell lymphoma cells to the CHOP regimen. Oncol Lett. 2018;15:3321-3328 pubmed publisher

Arakawa N, Okubo A, Yasuhira S, Takahashi K, Amano H, Akasaka T, et al. Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of β-lapachone in melanoma cell lines. Oncol Lett. 2018;15:2393-2400 pubmed publisher

Montani L, Pereira J, Norrmen C, Pohl H, Tinelli E, Trötzmüller M, et al. De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination. J Cell Biol. 2018;217:1353-1368 pubmed publisher

Hu Q, Khanna P, Ee Wong B, Lin Heng Z, Subhramanyam C, Thanga L, et al. Oxidative stress promotes exit from the stem cell state and spontaneous neuronal differentiation. Oncotarget. 2018;9:4223-4238 pubmed publisher

Xiao J, Shi Q, Li W, Mu X, Peng J, Li M, et al. ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation. Am J Cancer Res. 2018;8:132-143 pubmed

Guan S, Lu J, Zhao Y, Yu Y, Li H, Chen Z, et al. MELK is a novel therapeutic target in high-risk neuroblastoma. Oncotarget. 2018;9:2591-2602 pubmed publisher

Imamura M, Moon J, Chung K, Nakahira K, Muthukumar T, Shingarev R, et al. RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase. JCI Insight. 2018;3: pubmed publisher

Mervai Z, Egedi K, Kovalszky I, Baghy K. Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse. BMC Cancer. 2018;18:157 pubmed publisher

Jung D, Khurana A, Roy D, Kalogera E, Bakkum Gamez J, Chien J, et al. Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer. Sci Rep. 2018;8:2487 pubmed publisher

Garrido Gil P, Rodriguez Perez A, Dominguez Meijide A, Guerra M, Labandeira Garcia J. Bidirectional Neural Interaction Between Central Dopaminergic and Gut Lesions in Parkinson's Disease Models. Mol Neurobiol. 2018;55:7297-7316 pubmed publisher

Souza B, da Costa Lopez P, Menegotto P, Vieira I, Kersting N, Abujamra A, et al. Targeting Histone Deacetylase Activity to Arrest Cell Growth and Promote Neural Differentiation in Ewing Sarcoma. Mol Neurobiol. 2018;55:7242-7258 pubmed publisher

Ooki A, Begum A, Marchionni L, Vandenbussche C, Mao S, Kates M, et al. Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer. 2018;143:113-126 pubmed publisher

Tvingsholm S, Hansen M, Clemmensen K, Brix D, Rafn B, Frankel L, et al. Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zinc finger-1. Oncogenesis. 2018;7:14 pubmed publisher

Chen L, Chen J, Huang Y, Gu Y, Qiu J, Qian H, et al. The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Mol Cell. 2018;69:412-425.e6 pubmed publisher

Richter J, Stanley E, Ng E, Elefanty A, Traver D, Willert K. WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development. Genes (Basel). 2018;9: pubmed publisher

Chea C, Miyauchi M, Inubushi T, Febriyanti Ayuningtyas N, Subarnbhesaj A, Nguyen P, et al. Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma. PLoS ONE. 2018;13:e0191683 pubmed publisher

Panek M, Grabacka M, Pierzchalska M. The formation of intestinal organoids in a hanging drop culture. Cytotechnology. 2018;70:1085-1095 pubmed publisher

Yu Z, Tang P, Wang J, Bao S, Shieh J, Leung A, et al. Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight. 2018;3: pubmed publisher

Torika N, Asraf K, Apte R, Fleisher Berkovich S. Candesartan ameliorates brain inflammation associated with Alzheimer's disease. CNS Neurosci Ther. 2018;24:231-242 pubmed publisher

Salinas E, Gupta A, Sifford J, Oldenburg D, White D, Forrest J. Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection. PLoS Pathog. 2018;14:e1006865 pubmed publisher

Bresson L, Faraldo M, Di Cicco A, Quintanilla M, Glukhova M, Deugnier M. Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling. Development. 2018;145: pubmed publisher

Katreddy R, Bollu L, Su F, Xian N, Srivastava S, Thomas R, et al. Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt. Oncogenesis. 2018;7:5 pubmed publisher

Yang X, Zhang J, Duan L, Xiong H, Jiang Y, Liang H. Microglia activation mediated by toll-like receptor-4 impairs brain white matter tracts in rats. J Biomed Res. 2018;32:136-144 pubmed publisher

Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed publisher

Krishnan N, Bonham C, Rus I, Shrestha O, Gauss C, Haque A, et al. Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development. Nat Commun. 2018;9:283 pubmed publisher

Wang Z, Kim M, Martinez Ferrando I, Koleske A, Pandey A, Cole P. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry. 2018;57:1390-1398 pubmed publisher

Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, et al. Targeting IRF3 as a YAP agonist therapy against gastric cancer. J Exp Med. 2018;215:699-718 pubmed publisher

Vanzyl E, Rick K, Blackmore A, MacFarlane E, McKay B. Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin. PLoS ONE. 2018;13:e0191178 pubmed publisher

Li H, Ivarsson M, Walker Sperling V, Subleski J, Johnson J, Wright P, et al. Identification of an elaborate NK-specific system regulating HLA-C expression. PLoS Genet. 2018;14:e1007163 pubmed publisher

Kanaji N, Kamitori K, Hossain A, Noguchi C, Katagi A, Kadowaki N, et al. Additive antitumour effect of D‑allose in combination with cisplatin in non-small cell lung cancer cells. Oncol Rep. 2018;39:1292-1298 pubmed publisher

Festa B, Chen Z, Berquez M, Debaix H, Tokonami N, Prange J, et al. Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney. Nat Commun. 2018;9:161 pubmed publisher

Gwinn D, Lee A, Briones Martin del Campo M, Conn C, Simpson D, Scott A, et al. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018;33:91-107.e6 pubmed publisher

Hwang H, Tran D, Rebuffatti M, Li C, Knowlton A. Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLoS ONE. 2018;13:e0190374 pubmed publisher

Li J, Wang B, Kodali M, Chen C, Kim E, Patters B, et al. In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation. J Neuroinflammation. 2018;15:8 pubmed publisher

Kim K, Maio N, Singh A, Rouault T. Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. Hum Mol Genet. 2018;27:837-852 pubmed publisher

Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, et al. ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. Stem Cell Res Ther. 2018;9:2 pubmed publisher

Kanteti R, Mirzapoiazova T, Riehm J, Dhanasingh I, Mambetsariev B, Wang J, et al. Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma. Cancer Biol Ther. 2018;19:316-327 pubmed publisher

Lecoutre S, Pourpe C, Butruille L, Marousez L, Laborie C, Guinez C, et al. Reduced PPAR?2 expression in adipose tissue of male rat offspring from obese dams is associated with epigenetic modifications. FASEB J. 2018;: pubmed publisher

Liang M, Zhao T, Ma L, Guo Y. CHK1 inhibition sensitizes pancreatic cancer cells to gemcitabine via promoting CDK-dependent DNA damage and ribonucleotide reductase downregulation. Oncol Rep. 2018;39:1322-1330 pubmed publisher

Nishimura R, Okuda K, Gunji Y, Khalid A, Yamano Y, Yamashita Y, et al. BNIP3 expression in bovine follicle and corpus luteum. J Vet Med Sci. 2018;80:368-374 pubmed publisher

Saldate J, Shiau J, Cazares V, Stuenkel E. The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology. J Biol Chem. 2018;293:2232-2246 pubmed publisher

Zhao X, Sehgal M, Hou Z, Cheng J, Shu S, Wu S, et al. Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses. J Virol. 2018;92: pubmed publisher

Li G, Ma H, Yin Y, Wang J. CRP, IL‑2 and TNF‑α level in patients with uremia receiving hemodialysis. Mol Med Rep. 2018;17:3350-3355 pubmed publisher

Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, et al. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Mol Cell. 2018;69:87-99.e7 pubmed publisher

Schuhmacher L, Callejo G, Srivats S, Smith E. Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers. J Biol Chem. 2018;293:1756-1766 pubmed publisher

Schaler A, Myeku N. Cilostazol, a phosphodiesterase 3 inhibitor, activates proteasome-mediated proteolysis and attenuates tauopathy and cognitive decline. Transl Res. 2018;193:31-41 pubmed publisher

Bu Y, Yoshida A, Chitnis N, Altman B, Tameire F, Oran A, et al. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018;20:104-115 pubmed publisher

Song H, Fang S, Gao J, Wang J, Cao Z, Guo Z, et al. Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury. J Proteome Res. 2018;17:858-869 pubmed publisher

Dong L, Hu Y, Zhou L, Cheng X. P2X7 receptor antagonist protects retinal ganglion cells by inhibiting microglial activation in a rat chronic ocular hypertension model. Mol Med Rep. 2018;17:2289-2296 pubmed publisher

Strauch C, Manahan Vaughan D. In the Piriform Cortex, the Primary Impetus for Information Encoding through Synaptic Plasticity Is Provided by Descending Rather than Ascending Olfactory Inputs. Cereb Cortex. 2018;28:764-776 pubmed publisher

Gonzalez Hurtado E, Lee J, Choi J, Wolfgang M. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab. 2018;7:45-56 pubmed publisher

Wallot Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, et al. Systematic analysis of ATG13 domain requirements for autophagy induction. Autophagy. 2018;14:743-763 pubmed publisher

Alice A, Kramer G, Bambina S, Baird J, Bahjat K, Gough M, et al. Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity. J Immunol. 2018;200:177-185 pubmed publisher

Persaud A, Cormerais Y, Pouyssegur J, Rotin D. Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin. J Cell Sci. 2018;131: pubmed publisher

Skibiel A, Zachut M, do Amaral B, Levin Y, Dahl G. Liver proteomic analysis of postpartum Holstein cows exposed to heat stress or cooling conditions during the dry period. J Dairy Sci. 2018;101:705-716 pubmed publisher

Bayoumi A, Park K, Wang Y, Teoh J, Aonuma T, Tang Y, et al. A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes. J Mol Cell Cardiol. 2018;114:72-82 pubmed publisher

Venkataramani V, Küffer S, Cheung K, Jiang X, Trumper L, Wulf G, et al. CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas. Clin Cancer Res. 2018;24:460-473 pubmed publisher

Xu X, Li C, Gao X, Xia K, Guo H, Li Y, et al. Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders. Cell Res. 2018;28:48-68 pubmed publisher

Pearson Leary J, Jahagirdar V, Sage J, McNay E. Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4. Behav Brain Res. 2018;338:32-39 pubmed publisher

Pisani F, Cammalleri M, Dal Monte M, Locri F, Mola M, Nicchia G, et al. Potential role of the methylation of VEGF gene promoter in response to hypoxia in oxygen-induced retinopathy: beneficial effect of the absence of AQP4. J Cell Mol Med. 2018;22:613-627 pubmed publisher

Le Gallo M, Rudd M, Urick M, Hansen N, Merino M, Mutch D, et al. The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas. Cancer. 2018;124:65-73 pubmed publisher

Corkery D, Clarke L, Gebremeskel S, Salsman J, Pinder J, Le Page C, et al. Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking. Oncogene. 2018;37:174-184 pubmed publisher

Zhang J, Chen C. Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors. Mol Neurobiol. 2018;55:4802-4810 pubmed publisher

Ren J, Hathaway N, Crabtree G, Muegge K. Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes. Epigenetics. 2018;13:173-181 pubmed publisher

Khanna P, Chua P, Wong B, Yin C, Thike A, Wan W, et al. GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis. Oncotarget. 2017;8:115370-115383 pubmed publisher

Kitajima S, Lee K, Hikasa H, Sun W, Huang R, Yang H, et al. Hypoxia-inducible factor-1? promotes cell survival during ammonia stress response in ovarian cancer stem-like cells. Oncotarget. 2017;8:114481-114494 pubmed publisher

Cammalleri M, Locri F, Catalani E, Filippi L, Cervia D, Dal Monte M, et al. The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy. Front Cell Neurosci. 2017;11:395 pubmed publisher

Bulk E, Kramko N, Liashkovich I, Glaser F, Schillers H, Schnittler H, et al. KCa3.1 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and HMEC-1 endothelial cells. Oncotarget. 2017;8:112268-112282 pubmed publisher

Koi C, Izumi H, Kurita T, Nguyen T, Murakami M, Yoshiura Y, et al. Lovastatin induced Kruppel like factor 2 (KLF2), Kruppel like factor 6 (KLF6) and Ras homolog family member B (RHOB) genes and preferentially led to viability reduction of Cisplatin-resistant cells. Oncotarget. 2017;8:106429-106442 pubmed publisher

Hoppe Seyler K, Honegger A, Bossler F, Sponagel J, Bulkescher J, Lohrey C, et al. Viral E6/E7 oncogene and cellular hexokinase 2 expression in HPV-positive cancer cell lines. Oncotarget. 2017;8:106342-106351 pubmed publisher

Conde M, Michen S, Wiedemuth R, Klink B, Schrock E, Schackert G, et al. Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells. BMC Cancer. 2017;17:889 pubmed publisher

Ahn J, Son S, Oliveira S, Barber G. STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis. Cell Rep. 2017;21:3873-3884 pubmed publisher

Chou C, Lee Y, Liao C, Huang Y, Fan C. Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess A? accumulation in the hippocampus of mice with persistent cerebral toxocariasis. Parasit Vectors. 2017;10:620 pubmed publisher

Zhou W, Barkow J, Freed C. Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease. PLoS ONE. 2017;12:e0190160 pubmed publisher

Luedtke D, Niu X, Pan Y, Zhao J, Liu S, Edwards H, et al. Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Signal Transduct Target Ther. 2017;2:17012 pubmed publisher

Chen Z, Zhao Y, Yu Y, Pang J, Woodfield S, Tao L, et al. Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo. Oncotarget. 2017;8:104090-104103 pubmed publisher

Pei G, Buijze H, Liu H, Moura Alves P, Goosmann C, Brinkmann V, et al. The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Autophagy. 2017;13:2041-2055 pubmed publisher

Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, et al. Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60. PLoS ONE. 2017;12:e0189744 pubmed publisher

Pan R, Ruvolo V, Mu H, Leverson J, Nichols G, Reed J, et al. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer Cell. 2017;32:748-760.e6 pubmed publisher

Vanetti C, Bifari F, Vicentini L, Cattaneo M. Fatty acids rather than hormones restore in vitro angiogenesis in human male and female endothelial cells cultured in charcoal-stripped serum. PLoS ONE. 2017;12:e0189528 pubmed publisher

Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed publisher

Reese J, Bruinsma E, Monroe D, Negron V, Suman V, Ingle J, et al. ER? inhibits cyclin dependent kinases 1 and 7 in triple negative breast cancer. Oncotarget. 2017;8:96506-96521 pubmed publisher

Dinami R, Buemi V, Sestito R, Zappone A, Ciani Y, Mano M, et al. Epigenetic silencing of miR-296 and miR-512 ensures hTERT dependent apoptosis protection and telomere maintenance in basal-type breast cancer cells. Oncotarget. 2017;8:95674-95691 pubmed publisher

Ciołczyk Wierzbicka D, Gil D, Laidler P. Treatment of melanoma with selected inhibitors of signaling kinases effectively reduces proliferation and induces expression of cell cycle inhibitors. Med Oncol. 2017;35:7 pubmed publisher

Sun W, Rojas Y, Wang H, Yu Y, Wang Y, Chen Z, et al. EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma. Oncotarget. 2017;8:94780-94792 pubmed publisher

Eckert M, Klumpp L, Huber S. Cellular Effects of the Antiepileptic Drug Valproic Acid in Glioblastoma. Cell Physiol Biochem. 2017;44:1591-1605 pubmed publisher

Jalali R, Lodder J, Zandieh Doulabi B, Micha D, Melvin J, Catalán M, et al. The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice. Front Physiol. 2017;8:924 pubmed publisher

Dong L, Cheng X, Zhou L, Hu Y. Calcium channels are involved in EphB/ephrinB reverse signaling?induced apoptosis in a rat chronic ocular hypertension model. Mol Med Rep. 2017;: pubmed publisher

Mizumura K, Justice M, Schweitzer K, Krishnan S, Bronova I, Berdyshev E, et al. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 2017;: pubmed publisher

Wu J, Chiang M, Hsu P, Tsai D, Hung K, Wang Y, et al. O-GlcNAcylation is required for B cell homeostasis and antibody responses. Nat Commun. 2017;8:1854 pubmed publisher

Pei Y, Li G, Ran J, Wei F. Kinesin family member 11 contributes to the progression and prognosis of human breast cancer. Oncol Lett. 2017;14:6618-6626 pubmed publisher

Toba S, Jin M, Yamada M, Kumamoto K, Matsumoto S, Yasunaga T, et al. Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport. Sci Rep. 2017;7:16386 pubmed publisher

Messaoudi K, Ali A, Ishaq R, Palazzo A, Sliwa D, Bluteau O, et al. Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect. Nat Commun. 2017;8:1786 pubmed publisher

Tankiewicz Kwedlo A, Hermanowicz J, Domaniewski T, Pawlak K, Rusak M, Pryczynicz A, et al. Simultaneous use of erythropoietin and LFM-A13 as a new therapeutic approach for colorectal cancer. Br J Pharmacol. 2017;: pubmed publisher

Sarén T, Ramachandran M, Martikainen M, Yu D. Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity. Mol Ther Oncolytics. 2017;7:67-75 pubmed publisher

Boye T, Maeda K, Pezeshkian W, Sønder S, Haeger S, Gerke V, et al. Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair. Nat Commun. 2017;8:1623 pubmed publisher

Maschalidi S, Nunes Hasler P, Nascimento C, Sallent I, Lannoy V, Garfa Traoré M, et al. UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells. Nat Commun. 2017;8:1640 pubmed publisher

Li J, Song C, Rong Y, Kuang T, Wang D, Xu X, et al. Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer. Cell Cycle. 2017;:1-35 pubmed publisher

Luo W, Li S, Li C, Zheng Z, Cao P, Tong Z, et al. iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLoS Pathog. 2017;13:e1006693 pubmed publisher

Sethumadhavan S, Silva M, Philbrook P, Nguyen T, Hatfield S, Ohta A, et al. Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. PLoS ONE. 2017;12:e0187314 pubmed publisher

Subarnbhesaj A, Miyauchi M, Chanbora C, Mikuriya A, Nguyen P, Furusho H, et al. Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma. PLoS ONE. 2017;12:e0187092 pubmed publisher

Wu Y, Pons V, Goudet A, Panigai L, Fischer A, Herweg J, et al. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments. Sci Rep. 2017;7:15567 pubmed publisher

Gonçalves A, Adlesic M, Brandt S, Hejhal T, Harlander S, Sommer L, et al. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat Commun. 2017;8:1466 pubmed publisher

Frislev H, Boye T, Nylandsted J, Otzen D. Liprotides kill cancer cells by disrupting the plasma membrane. Sci Rep. 2017;7:15129 pubmed publisher

Ruan Y, Zeng F, Cheng Z, Zhao X, Fu P, Chen H. High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma. Oncol Lett. 2017;14:5727-5734 pubmed publisher

Blakely C, Watkins T, Wu W, Gini B, Chabon J, McCoach C, et al. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017;49:1693-1704 pubmed publisher

Chen L, Chen J, Zhang X, Gu Y, Xiao R, Shao C, et al. R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters. Mol Cell. 2017;68:745-757.e5 pubmed publisher

Gunawardhana K, Hardin P. VRILLE Controls PDF Neuropeptide Accumulation and Arborization Rhythms in Small Ventrolateral Neurons to Drive Rhythmic Behavior in Drosophila. Curr Biol. 2017;27:3442-3453.e4 pubmed publisher

Reitsma J, Liu X, Reichermeier K, Moradian A, Sweredoski M, Hess S, et al. Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Cell. 2017;171:1326-1339.e14 pubmed publisher

Good K, de Paz A, Tyagi M, Cheema M, Thambirajah A, Gretzinger T, et al. Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. Epigenetics. 2017;: pubmed publisher

Long J, Huang C, Chen Y, Zhang Y, Shi S, Wu L, et al. Telomeric TERB1-TRF1 interaction is crucial for male meiosis. Nat Struct Mol Biol. 2017;24:1073-1080 pubmed publisher

Zhu W, Chi N, Zou P, Chen H, Tang G, Zhao W. Effect of docosahexaenoic acid on traumatic brain injury in rats. Exp Ther Med. 2017;14:4411-4416 pubmed publisher

Feliciano A, Garcia Mayea Y, Jubierre L, Mir C, Hummel M, Castellvi J, et al. miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer. Cell Death Dis. 2017;8:e3141 pubmed publisher

Badreddine A, Zarrouk A, Karym E, Debbabi M, Nury T, Meddeb W, et al. Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N. Int J Mol Sci. 2017;18: pubmed publisher

de Paiva P, Delcorso M, Matheus V, de Queiroz S, Collares Buzato C, Arana S. Acute toxicity of commercial atrazine in Piaractus mesopotamicus: Histopathological, ultrastructural, molecular, and genotoxic evaluation. Vet World. 2017;10:1008-1019 pubmed publisher

Pozhidaeva A, Valles G, Wang F, Wu J, Sterner D, Nguyen P, et al. USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms. Cell Chem Biol. 2017;24:1501-1512.e5 pubmed publisher

Wenzel S, Tyurina Y, Zhao J, St Croix C, Dar H, Mao G, et al. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017;171:628-641.e26 pubmed publisher

Shanmugasundaram K, Nayak B, Friedrichs W, Kaushik D, Rodriguez R, Block K. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance. Nat Commun. 2017;8:997 pubmed publisher

Zera K, Zastre J. Thiamine deficiency activates hypoxia inducible factor-1? to facilitate pro-apoptotic responses in mouse primary astrocytes. PLoS ONE. 2017;12:e0186707 pubmed publisher

Huggins I, Bos T, Gaylord O, Jessen C, Lonquich B, Puranen A, et al. The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells. Nat Commun. 2017;8:1034 pubmed publisher