product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
ANTI-FLAG(R) M2 Affinity Gel
catalog :
A2220
conjugate :
nonconjugated
reactivity :
human, brewer's yeast, fruit fly
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, other
more info or order :
citations: 757
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; human; fig 1
David A, Amartely H, Rabinowicz N, Shamir M, Friedler A, Izraeli S. Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells. Sci Rep. 2016;6:24296 pubmed publisher
  • western blot; human; 1:5000; fig 1
Decorsière A, Mueller H, van Breugel P, Abdul F, Gerossier L, Beran R, et al. Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature. 2016;531:386-9 pubmed publisher
  • immunoprecipitation; human; fig 1A
Ding X, Jiang W, Zhou P, Liu L, Wan X, Yuan X, et al. Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS ONE. 2015;10:e0145023 pubmed publisher
  • other; human
Tong X, Zhang D, Guha A, Arthurs B, Cazares V, Gupta N, et al. CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1. PLoS ONE. 2015;10:e0139725 pubmed publisher
  • western blot; human; fig 4
Subbaiah V, Zhang Y, Rajagopalan D, Abdullah L, Yeo Teh N, Tomaić V, et al. E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60. Oncogene. 2016;35:2062-74 pubmed publisher
  • western blot; brewer's yeast; 1:4000; fig s11
Iacovella M, Golfieri C, Massari L, Busnelli S, Pagliuca C, Dal Maschio M, et al. Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation. Nat Commun. 2015;6:6643 pubmed publisher
  • western blot; human; fig 2
Sun L, Hartson S, Matts R. Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics. Biochim Biophys Acta. 2015;1854:365-80 pubmed publisher
  • western blot; human; fig 6
Lindsey Boltz L, Kemp M, Capp C, Sancar A. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling. Cell Cycle. 2015;14:99-108 pubmed publisher
  • immunoprecipitation; human
He W, Hu C, Hou J, Fan L, Xu Y, Liu M, et al. Microtubule-associated protein 1 light chain 3 interacts with and contributes to growth inhibiting effect of PML. PLoS ONE. 2014;9:e113089 pubmed publisher
  • immunoprecipitation; fruit fly
Chen D, Wu C, Zhao S, Geng Q, Gao Y, Li X, et al. Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. PLoS Genet. 2014;10:e1004797 pubmed publisher
  • immunoprecipitation; human; fig 6
Larsen D, Hari F, Clapperton J, Gwerder M, Gutsche K, Altmeyer M, et al. The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nat Cell Biol. 2014;16:792-803 pubmed publisher
  • immunoprecipitation; human
Charan R, Johnson B, Zaganelli S, Nardozzi J, LaVoie M. Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death Dis. 2014;5:e1313 pubmed publisher
  • immunoprecipitation; human; fig 2c
Ma L, Aslanian A, Sun H, Jin M, Shi Y, Yates J, et al. Identification of small ubiquitin-like modifier substrates with diverse functions using the Xenopus egg extract system. Mol Cell Proteomics. 2014;13:1659-75 pubmed publisher
  • immunoprecipitation; human
Yim D, Ghosh S, Guy G, Virshup D. Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene. 2015;34:474-84 pubmed publisher
Deng M, Tam J, Wang L, Liang K, Li S, Zhang L, et al. TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nat Commun. 2020;11:2193 pubmed publisher
Manage K, Rogers A, Wallis D, Uebel C, Anderson D, Nguyen D, et al. A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans. elife. 2020;9: pubmed publisher
Hu D, Chen H, Lou L, Zhang H, Yang G. SKA3 promotes lung adenocarcinoma metastasis through the EGFR-PI3K-Akt axis. Biosci Rep. 2020;40: pubmed publisher
Tamburri S, Lavarone E, Fernandez Perez D, Conway E, Zanotti M, Manganaro D, et al. Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression. Mol Cell. 2019;: pubmed publisher
Kang M, Kim J, Ryu E, Ha N, Hwang S, Kim B, et al. PCNA Unloading Is Negatively Regulated by BET Proteins. Cell Rep. 2019;29:4632-4645.e5 pubmed publisher
Cai W, Su L, Liao L, Liu Z, Langbein L, Dulaimi E, et al. PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. Nat Commun. 2019;10:5800 pubmed publisher
Esfahani M, Lee L, Jeon Y, Flynn R, Stehr H, Hui A, et al. Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Nat Commun. 2019;10:5712 pubmed publisher
Santos Barriopedro I, Li Y, Bahl S, Seto E. HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1. Genes Cancer. 2019;10:119-133 pubmed publisher
Xu S, Zhan M, Jiang C, He M, Yang L, Shen H, et al. Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer. Nat Commun. 2019;10:5492 pubmed publisher
Huynh N, Ou Q, Cox P, Lill R, King Jones K. Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET. Nat Commun. 2019;10:5463 pubmed publisher
Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, et al. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Rep. 2019;29:2028-2040.e8 pubmed publisher
Gupta S, Ylä Anttila P, Sandalova T, Sun R, Achour A, Masucci M. 14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases. PLoS Pathog. 2019;15:e1008146 pubmed publisher
Belli M, Secchi C, Stupack D, Shimasaki S. FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3. J Endocr Soc. 2019;3:2064-2081 pubmed publisher
Busch J, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schondorf T, et al. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Rep. 2019;29:1728-1738.e9 pubmed publisher
Bury M, Le Calve B, Lessard F, Dal Maso T, Saliba J, Michiels C, et al. NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor. Cell Rep. 2019;29:1469-1481.e9 pubmed publisher
Schwob A, Teruel E, Dubuisson L, Lormières F, Verlhac P, Abudu Y, et al. SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function. Sci Rep. 2019;9:16014 pubmed publisher
Martino J, Brunette G, Barroso González J, Moiseeva T, Smith C, Bakkenist C, et al. The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. Nucleic Acids Res. 2019;47:10151-10165 pubmed publisher
Yan Q, Shields E, Bonasio R, Sarma K. Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach. Cell Rep. 2019;29:1369-1380.e5 pubmed publisher
Wu K, Jones R, Tachie Menson T, MacArtney T, Wood N, Varghese J, et al. Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. Wellcome Open Res. 2019;4:133 pubmed publisher
Higuchi C, Yamamoto M, Shin S, Miyamoto K, Matsumoto K. Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway. Biol Open. 2019;8: pubmed publisher
Wible D, Chao H, Tang D, Bratton S. ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. Cell Discov. 2019;5:42 pubmed publisher
LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai R, Kara H, et al. LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. Sci Adv. 2019;5:eaay3068 pubmed publisher
Wu N, Nguyen X, Wang L, Appourchaux R, Zhang C, Panthu B, et al. The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation. PLoS Pathog. 2019;15:e1008093 pubmed publisher
Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, et al. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell. 2019;76:857-871.e9 pubmed publisher
Guo L, Wang R, Zhang K, Yuan J, Wang J, Wang X, et al. A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation. J Cell Biol. 2019;218:3773-3794 pubmed publisher
Parker M, Bell M, Mir M, Kao J, Darzacq X, Botchan M, et al. A new class of disordered elements controls DNA replication through initiator self-assembly. elife. 2019;8: pubmed publisher
Tsai P, Chien Y, Wang M, Hsu C, Laurent B, Chou S, et al. Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network. Nucleic Acids Res. 2019;47:10115-10133 pubmed publisher
Li J, Han W, Wu K, Li Y, Liu Q, Lu W. A Conserved Tyrosine Residue in Slitrk3 Carboxyl-Terminus Is Critical for GABAergic Synapse Development. Front Mol Neurosci. 2019;12:213 pubmed publisher
Xing G, Jing H, Zhang L, Cao Y, Li L, Zhao K, et al. A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. elife. 2019;8: pubmed publisher
Lim C, Davis O, Shin H, Zhang J, Berdan C, Jiang X, et al. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nat Cell Biol. 2019;21:1206-1218 pubmed publisher
Du C, Hansen L, Singh S, Wang F, Sun R, Moure C, et al. A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. Cell Rep. 2019;28:3199-3211.e5 pubmed publisher
Hansen A, Hsieh T, Cattoglio C, Pustova I, Saldaña Meyer R, Reinberg D, et al. Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF. Mol Cell. 2019;76:395-411.e13 pubmed publisher
Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, et al. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun. 2019;10:4158 pubmed publisher
Cowen L, Luo H, Tang Y. Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1. Sci Rep. 2019;9:13097 pubmed publisher
Balta E, Hardt R, Liang J, Kirchgessner H, Orlik C, Jahraus B, et al. Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells. Nat Commun. 2019;10:4073 pubmed publisher
Pajtler K, Wei Y, Okonechnikov K, Silva P, Vouri M, Zhang L, et al. YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nat Commun. 2019;10:3914 pubmed publisher
Yuan R, Liu Q, Segeren H, Yuniati L, Guardavaccaro D, Lebbink R, et al. Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression. EMBO J. 2019;38:e101430 pubmed publisher
DeDiego M, Nogales A, Martinez Sobrido L, Topham D. Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication. MBio. 2019;10: pubmed publisher
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, et al. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019;572:614-619 pubmed publisher
Yang Y, Willis T, Button R, Strang C, Fu Y, Wen X, et al. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nat Commun. 2019;10:3759 pubmed publisher
Kim Y, Lee S, Kim S, Jang H, Hwang I, Jin S, et al. Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Nat Chem Biol. 2019;15:907-916 pubmed publisher
Gottschalk B, Klec C, Leitinger G, Bernhart E, Rost R, Bischof H, et al. MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex. Nat Commun. 2019;10:3732 pubmed publisher
Han T, Jiang S, Zheng H, Yin Q, Xie M, Little M, et al. Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Nat Commun. 2019;10:3716 pubmed publisher
Pulos Holmes M, Srole D, Juarez M, Lee A, McSwiggen D, Ingolia N, et al. Repression of ferritin light chain translation by human eIF3. elife. 2019;8: pubmed publisher
Cohen Katsenelson K, Stender J, Kawashima A, Lordén G, Uchiyama S, Nizet V, et al. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. elife. 2019;8: pubmed publisher
Morgenstern T, Park J, Fan Q, Colecraft H. A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits. elife. 2019;8: pubmed publisher
Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, et al. USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication. elife. 2019;8: pubmed publisher
Nambiar T, Billon P, Diedenhofen G, Hayward S, Taglialatela A, Cai K, et al. Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant. Nat Commun. 2019;10:3395 pubmed publisher
Kim D, Camacho C, Nagari A, Malladi V, Challa S, Kraus W. Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Mol Cell. 2019;: pubmed publisher
Zhang X, Du K, Lou Z, Ding K, Zhang F, Zhu J, et al. The CtBP1-HDAC1/2-IRF1 transcriptional complex represses the expression of the long noncoding RNA GAS5 in human osteosarcoma cells. Int J Biol Sci. 2019;15:1460-1471 pubmed publisher
Singh A, Manjunath L, Kundu P, Sahoo S, Das A, Suma H, et al. Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor. EMBO J. 2019;38:e100727 pubmed publisher
Yun H, Kim M, Lee H, Kim W, Shin J, Kim H, et al. Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus. PLoS Biol. 2019;17:e3000367 pubmed publisher
Romilly C, Deindl S, Wagner E. The ribosomal protein S1-dependent standby site in tisB mRNA consists of a single-stranded region and a 5' structure element. Proc Natl Acad Sci U S A. 2019;116:15901-15906 pubmed publisher
Agrotis A, von Chamier L, Oliver H, Kiso K, Singh T, Ketteler R. Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins. J Biol Chem. 2019;294:12610-12621 pubmed publisher
He X, Zhu Y, Zhang Y, Geng Y, Gong J, Geng J, et al. RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation. EMBO J. 2019;38:e100978 pubmed publisher
Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, et al. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Mol Cell. 2019;75:823-834.e5 pubmed publisher
Gillingham A, Bertram J, Begum F, Munro S. In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation. elife. 2019;8: pubmed publisher
Chung C, Shin H, Berdan C, Ford B, Ward C, Olzmann J, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019;15:776-785 pubmed publisher
Chen Z, Picaud S, Filippakopoulos P, D Angiolella V, Bullock A. Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase. Structure. 2019;: pubmed publisher
Talbot B, Vandorpe D, Stotter B, Alper S, SCHLONDORFF J. Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking and activity of the nonselective cation channel TRPC6. J Biol Chem. 2019;: pubmed publisher
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature. 2019;571:127-131 pubmed publisher
Krasnopolsky S, Marom L, Victor R, Kuzmina A, Schwartz J, Fujinaga K, et al. Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation. Retrovirology. 2019;16:16 pubmed publisher
Wang Z, Zhou L, Xiong Y, Yu S, Li H, Fan J, et al. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/T-cell factor complex. Br J Pharmacol. 2019;176:3390-3406 pubmed publisher
Shi C, Nabar N, Huang N, Kehrl J. SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes. Cell Death Discov. 2019;5:101 pubmed publisher
Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher
Li M, Zhang C, Zong Y, Feng J, Ma T, Hu M, et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;: pubmed publisher
Yang Q, Bai S, Li L, Li S, Zhang Y, Munir M, et al. Human hemoglobin subunit beta functions as a pleiotropic regulator of the RIG-I/MDA5-mediated antiviral innate immune responses. J Virol. 2019;: pubmed publisher
Lopez Martinez D, Kupculak M, Yang D, Yoshikawa Y, Liang C, Wu R, et al. Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage. Cell Rep. 2019;27:2990-3005.e5 pubmed publisher
Coulombe P, Nassar J, Peiffer I, Stanojcic S, Sterkers Y, Delamarre A, et al. The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. Nat Commun. 2019;10:2426 pubmed publisher
Lu Y, Stuart J, Talbot Cooper C, Agrawal Singh S, Huntly B, Smid A, et al. Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A. 2019;116:11997-12006 pubmed publisher
Yoon W, Hwang S, Lee S, Chung J. Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. PLoS Genet. 2019;15:e1008184 pubmed publisher
van de Kooij B, Creixell P, van Vlimmeren A, Joughin B, Miller C, Haider N, et al. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs. elife. 2019;8: pubmed publisher
Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell S, et al. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature. 2019;: pubmed publisher
Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, et al. PES1 is a critical component of telomerase assembly and regulates cellular senescence. Sci Adv. 2019;5:eaav1090 pubmed publisher
Gregersen L, Mitter R, Ugalde A, Nojima T, Proudfoot N, Agami R, et al. SCAF4 and SCAF8, mRNA Anti-Terminator Proteins. Cell. 2019;: pubmed publisher
Zavodszky E, Hegde R. Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors. elife. 2019;8: pubmed publisher
Nowak D, Katsenelson K, Watrud K, Chen M, Mathew G, D Andrea V, et al. The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. J Cell Biol. 2019;218:1943-1957 pubmed publisher
Saneyoshi T, Matsuno H, Suzuki A, Murakoshi H, Hedrick N, Agnello E, et al. Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP. Neuron. 2019;: pubmed publisher
Shang Z, Zhao J, Zhang Q, Cao C, Tian S, Zhang K, et al. USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis. J Biol Chem. 2019;294:9844-9857 pubmed publisher
Galvan D, Long J, Green N, CHANG B, Lin J, Schumacker P, et al. Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice. J Clin Invest. 2019;130:2807-2823 pubmed publisher
Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, et al. The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription. Nat Commun. 2019;10:2071 pubmed publisher
Zeng X, Ye M, Resch J, Jedrychowski M, Hu B, Lowell B, et al. Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis. Nature. 2019;569:229-235 pubmed publisher
Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts E, et al. K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Nat Commun. 2019;10:1870 pubmed publisher
Chino H, Hatta T, Natsume T, Mizushima N. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Mol Cell. 2019;74:909-921.e6 pubmed publisher
Topacio B, Zatulovskiy E, Cristea S, Xie S, Tambo C, Rubin S, et al. Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. Mol Cell. 2019;74:758-770.e4 pubmed publisher
Princely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al. NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed publisher
Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed publisher
Zhang M, Wang B, Li T, Liu R, Xiao Y, Geng X, et al. Mammalian CST averts replication failure by preventing G-quadruplex accumulation. Nucleic Acids Res. 2019;47:5243-5259 pubmed publisher
Wauters F, Cornelissen T, Imberechts D, Martin S, Koentjoro B, Sue C, et al. LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10. Autophagy. 2019;:1-20 pubmed publisher
Jiang Y, Zhang Y, Leung J, Fan C, Popov K, Su S, et al. MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression. Nat Commun. 2019;10:1515 pubmed publisher
Park O, Ha H, Lee Y, Boo S, Kwon D, Song H, et al. Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex. Mol Cell. 2019;74:494-507.e8 pubmed publisher
Olson C, Liang Y, Leggett A, Park W, Li L, Mills C, et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019;26:792-803.e10 pubmed publisher
Liu Z, Mar K, Hanners N, Perelman S, Kanchwala M, Xing C, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;: pubmed publisher
Akande O, Damle P, Pop M, Sherman N, Szomju B, Litovchick L, et al. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. Cell Rep. 2019;26:3323-3335.e4 pubmed publisher
Skjesol A, Yurchenko M, Bösl K, Gravastrand C, Nilsen K, Grøvdal L, et al. The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathog. 2019;15:e1007684 pubmed publisher
Aho E, Wang J, Gogliotti R, Howard G, Phan J, Acharya P, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019;26:2916-2928.e13 pubmed publisher
Zheng Y, Ramsamooj S, Li Q, Johnson J, Yaron T, Sharra K, et al. Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase. Sci Rep. 2019;9:4190 pubmed publisher
Su L, Zhou L, Chen F, Wang H, Qian H, Sheng Y, et al. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 2019;38: pubmed publisher
Sharma N, Pollina E, Nagy M, Yap E, DiBiase F, Hrvatin S, et al. ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation. Neuron. 2019;102:390-406.e9 pubmed publisher
Gleason C, Oses Prieto J, Li K, Saha B, Situ G, Burlingame A, et al. Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt. J Cell Sci. 2019;132: pubmed publisher
Kumar S, Gu Y, Abudu Y, Bruun J, Jain A, Farzam F, et al. Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation. Dev Cell. 2019;: pubmed publisher
Zhang Y, Li T, Zhang L, Shangguan F, Shi G, Wu X, et al. Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. EBioMedicine. 2019;41:408-419 pubmed publisher
Hota S, Johnson J, Verschueren E, Thomas R, Blotnick A, Zhu Y, et al. Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis. Development. 2019;: pubmed publisher
Antas P, Novellasdemunt L, Kucharska A, Massie I, Carvalho J, Oukrif D, et al. SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization. Cell Rep. 2019;26:2266-2273.e4 pubmed publisher
Gopalakrishnan R, Marr S, Kingston R, Winston F. A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation. Nucleic Acids Res. 2019;47:3888-3903 pubmed publisher
Wang J, Chan B, Tong M, Paung Y, Jo U, MARTIN D, et al. Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway. PLoS Genet. 2019;15:e1007983 pubmed publisher
Munnur D, Somers J, Skalka G, Weston R, Jukes Jones R, Bhogadia M, et al. NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Cell Rep. 2019;26:2028-2036.e6 pubmed publisher
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