This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Aprotinin from bovine lung
catalog :
A1153
citations: 90
Reference
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Hirt M, Werner T, Indenbirken D, Alawi M, Demin P, Kunze A, et al. Deciphering the microRNA signature of pathological cardiac hypertrophy by engineered heart tissue- and sequencing-technology. J Mol Cell Cardiol. 2015;81:1-9 pubmed publisher
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Royston D. The current place of aprotinin in the management of bleeding. Anaesthesia. 2015;70 Suppl 1:46-9, e17 pubmed publisher
Réveillon D, Abadie E, Séchet V, Brient L, Savar V, Bardouil M, et al. Beta-N-methylamino-L-alanine: LC-MS/MS optimization, screening of cyanobacterial strains and occurrence in shellfish from Thau, a French Mediterranean lagoon. Mar Drugs. 2014;12:5441-67 pubmed publisher
. Regulatory decisions pertaining to aprotinin may be putting patients at risk. CMAJ. 2014;186:1379-86 pubmed publisher
Kira S, Tabata K, Shirahama Noda K, Nozoe A, Yoshimori T, Noda T. Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy. Autophagy. 2014;10:1565-78 pubmed publisher
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Two A, Hata T, Nakatsuji T, Coda A, Kotol P, Wu W, et al. Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor. J Invest Dermatol. 2014;134:1143-1145 pubmed publisher
Sunyakumthorn P, Petchampai N, Grasperge B, Kearney M, Sonenshine D, Macaluso K. Gene expression of tissue-specific molecules in ex vivo Dermacentor variabilis (Acari: Ixodidae) during rickettsial exposure. J Med Entomol. 2013;50:1089-96 pubmed
Fiedler J, Stöhr A, Gupta S, Hartmann D, Holzmann A, Just A, et al. Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization. Antioxid Redox Signal. 2014;21:1167-76 pubmed publisher
Molnar T, Vörös J, Szeder B, Takáts K, Kardos J, Katona G, et al. Comparison of complexes formed by a crustacean and a vertebrate trypsin with bovine pancreatic trypsin inhibitor - the key to achieving extreme stability?. FEBS J. 2013;280:5750-63 pubmed publisher
Cheng A, Tsai I. Functional characterization of a slow and tight-binding inhibitor of plasmin isolated from Russell's viper venom. Biochim Biophys Acta. 2014;1840:153-9 pubmed publisher
Pagano D, Freemantle N. Reply to the editor. J Thorac Cardiovasc Surg. 2013;146:732 pubmed publisher
Catalá López F. Clinical evidence from randomized trials, network meta-analyses, and conflicts of interests. J Thorac Cardiovasc Surg. 2013;146:731-2 pubmed publisher
Kaya H, Kafali M, Aydin K, Kocak S, Sahin M, Duran A, et al. Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rabbits. J Pak Med Assoc. 2013;63:32-7 pubmed
Walker A. Matching on provider is risky. J Clin Epidemiol. 2013;66:S65-8 pubmed publisher
Rosén M. EMA, transparency, and decision-making process. Lancet. 2013;382:26-7 pubmed publisher
Godoy M, Castro Vazquez A, Castro Vasquez A, Vega I. Endosymbiotic and host proteases in the digestive tract of the invasive snail Pomacea canaliculata: diversity, origin and characterization. PLoS ONE. 2013;8:e66689 pubmed publisher
Khan M, Islam M, Kuroda Y. Analysis of protein aggregation kinetics using short amino acid peptide tags. Biochim Biophys Acta. 2013;1834:2107-15 pubmed publisher
Ohnishi Y, Yamada T, Kurihara K, Tanaka I, Sakiyama F, Masaki T, et al. Neutron and X-ray crystallographic analysis of Achromobacter protease I at pD 8.0: protonation states and hydration structure in the free-form. Biochim Biophys Acta. 2013;1834:1642-7 pubmed publisher
Ortmann E, Besser M, Klein A. Antifibrinolytic agents in current anaesthetic practice. Br J Anaesth. 2013;111:549-63 pubmed publisher
McMullan V, Alston R. III. Aprotinin and cardiac surgery: a sorry tale of evidence misused. Br J Anaesth. 2013;110:675-8 pubmed publisher
Sathyamoorthy B, Singarapu K, Garcia A, Szyperski T. Protein conformational space populated in solution probed with aromatic residual dipolar (13) C-(1) H couplings. Chembiochem. 2013;14:684-8 pubmed publisher
Meybohm P, Herrmann E, Nierhoff J, Zacharowski K. Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients. PLoS ONE. 2013;8:e58009 pubmed publisher
Roberts I, Shakur H, Ker K, Coats T. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2012;12:CD004896 pubmed
Millers E, Johnson L, Birrell G, Masci P, Lavin M, de Jersey J, et al. The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS ONE. 2013;8:e54104 pubmed publisher
Later A, Sitniakowsky L, van Hilten J, van de Watering L, Brand A, Smit N, et al. Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery. J Thorac Cardiovasc Surg. 2013;145:1611-6, 1616.e1-4 pubmed publisher
Tvarijonaviciute A, Martinez Subiela S, Ceron J. Influence of different storage conditions and anticoagulants on the measurement of total and acylated ghrelin in dogs: a preliminary study. Vet Rec. 2013;172:289 pubmed publisher
Catalá López F. Safety of aprotinin in adult cardiac surgery: revisiting the validity of a mixed-treatment comparison meta-analysis. J Thorac Cardiovasc Surg. 2013;145:610 pubmed publisher
Wan H, Lee K, Kim B, Zou F, Yoon H, Je Y, et al. A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor. PLoS ONE. 2013;8:e53343 pubmed publisher
Matsuda T, Watanabe S, Kigawa T. Cell-free synthesis system suitable for disulfide-containing proteins. Biochem Biophys Res Commun. 2013;431:296-301 pubmed publisher
Glotzbach B, Schmelz S, Reinwarth M, Christmann A, Heinz D, Kolmar H. Structural characterization of Spinacia oleracea trypsin inhibitor III (SOTI-III). Acta Crystallogr D Biol Crystallogr. 2013;69:114-20 pubmed publisher
Dauter Z. Placement of molecules in (not out of) the cell. Acta Crystallogr D Biol Crystallogr. 2013;69:2-4 pubmed publisher
Reinwarth M, Glotzbach B, Tomaszowski M, Fabritz S, Avrutina O, Kolmar H. Oxidative folding of peptides with cystine-knot architectures: kinetic studies and optimization of folding conditions. Chembiochem. 2013;14:137-46 pubmed publisher
Bhunia B, Basak B, Mandal T, Bhattacharya P, Dey A. Effect of pH and temperature on stability and kinetics of novel extracellular serine alkaline protease (70 kDa). Int J Biol Macromol. 2013;54:1-8 pubmed publisher
Martin K, Gertler R, MacGuill M, Mayr N, Hapfelmeier A, Hörer J, et al. Replacement of aprotinin by ε-aminocaproic acid in infants undergoing cardiac surgery: consequences for blood loss and outcome. Br J Anaesth. 2013;110:615-21 pubmed publisher
Fan Y, Lin R, Yang L, Ye L, Yu J, Shu Q. Retrospective cohort analysis of a single dose of aprotinin use in children undergoing cardiac surgery: a single-center experience. Paediatr Anaesth. 2013;23:242-9 pubmed publisher
Lecker I, Wang D, Romaschin A, Peterson M, Mazer C, Orser B. Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. J Clin Invest. 2012;122:4654-66 pubmed publisher
Later A, Bruggemans E, Romijn F, Van Pelt J, Klautz R. A comparative study of the immune modulating properties of antifibrinolytics in cardiac surgery. Cytokine. 2013;61:438-44 pubmed publisher
Ranasinghe S, McManus D. Structure and function of invertebrate Kunitz serine protease inhibitors. Dev Comp Immunol. 2013;39:219-27 pubmed publisher
Maruna P, Klein A, Kunstyr J, Plocová K, Mlejnsky F, Lindner J. Aprotinin reduces the procalcitonin rise associated with complex cardiac surgery and cardiopulmonary bypass. Physiol Res. 2013;62:27-33 pubmed
Fenley A, Muddana H, Gilson M. Entropy-enthalpy transduction caused by conformational shifts can obscure the forces driving protein-ligand binding. Proc Natl Acad Sci U S A. 2012;109:20006-11 pubmed publisher
Riddell R, Buth K, Sullivan J. The risks associated with aprotinin use: a retrospective study of cardiac cases in Nova Scotia. Can J Anaesth. 2013;60:16-23 pubmed publisher
Hirt M, Sörensen N, Bartholdt L, Boeddinghaus J, Schaaf S, Eder A, et al. Increased afterload induces pathological cardiac hypertrophy: a new in vitro model. Basic Res Cardiol. 2012;107:307 pubmed publisher
Beckerman Z, Shopen Y, Alon H, Cohen O, Nir R, Adler Z, et al. Coronary artery bypass grafting after aprotinin: are we doing better?. J Thorac Cardiovasc Surg. 2013;145:243-8 pubmed publisher
Schaaf S, Shibamiya A, Mewe M, Eder A, Stöhr A, Hirt M, et al. Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology. PLoS ONE. 2011;6:e26397 pubmed publisher
Slobodin B, Gerst J. RaPID: an aptamer-based mRNA affinity purification technique for the identification of RNA and protein factors present in ribonucleoprotein complexes. Methods Mol Biol. 2011;714:387-406 pubmed publisher
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Shin Y, Park H, Shin S, Lee Y, Park S, Jo S, et al. Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. Antimicrob Agents Chemother. 2010;54:2855-66 pubmed publisher
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product information
Catalog Number :
A1153
Product Name :
Aprotinin from bovine lung
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
lyophilized powder, 3-8 TIU/mg solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA