Published Application/Species/Sample/Dilution | Reference |
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- western blot; mouse; loading ...
| Atashpaz S, Samadi Shams S, Gonzalez J, Sebestyén E, Arghavanifard N, Gnocchi A, et al. ATR expands embryonic stem cell fate potential in response to replication stress. elife. 2020;9: pubmed publisher
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- western blot; human; 1:500; loading ...; fig 3c
| Tan S, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell. 2017;169:1105-1118.e15 pubmed publisher
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- western blot; human; 1:2000; fig s6
| Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
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- western blot; mouse; 1:3000; fig 3
| Rein K, Yanez D, Terré B, Palenzuela L, Aivio S, Wei K, et al. EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res. 2015;43:7371-87 pubmed publisher
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- immunocytochemistry; human; fig 4
| Van Sluis M, McStay B. A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev. 2015;29:1151-63 pubmed publisher
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| Shimada M, Tsukada K, Kagawa N, Matsumoto Y. Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells. J Radiat Res. 2019;60:719-728 pubmed publisher
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| Sarraf S, Sideris D, Giagtzoglou N, Ni L, Kankel M, Sen A, et al. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Rep. 2019;29:225-235.e5 pubmed publisher
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| Pessina F, Giavazzi F, Yin Y, Gioia U, Vitelli V, Galbiati A, et al. Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors. Nat Cell Biol. 2019;21:1286-1299 pubmed publisher
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| Velichko A, Petrova N, Luzhin A, Strelkova O, Ovsyannikova N, Kireev I, et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription. Nucleic Acids Res. 2019;: pubmed publisher
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| Wu Z, Qiu M, Guo Y, Zhao J, Liu Z, Wang H, et al. OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair. Cancer Cell Int. 2019;19:99 pubmed publisher
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| Kari V, Raul S, Henck J, Kitz J, Kramer F, Kosinsky R, et al. The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. Clin Epigenetics. 2019;11:4 pubmed publisher
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| Bhatia V, Valdés Sánchez L, Rodríguez Martínez D, Bhattacharya S. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice. F1000Res. 2018;7:1233 pubmed publisher
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| Baranes Bachar K, Levy Barda A, Oehler J, Reid D, Soria Bretones I, Voss T, et al. The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. Mol Cell. 2018;69:866-878.e7 pubmed publisher
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| Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, et al. Exosomes maintain cellular homeostasis by excreting harmful DNA from cells. Nat Commun. 2017;8:15287 pubmed publisher
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| Rossiello F, Aguado J, Sepe S, Iannelli F, Nguyen Q, Pitchiaya S, et al. DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs. Nat Commun. 2017;8:13980 pubmed publisher
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| Roohi J, Crowe J, Loredan D, Anyane Yeboa K, Mansukhani M, Omesi L, et al. New diagnosis of atypical ataxia-telangiectasia in a 17-year-old boy with T-cell acute lymphoblastic leukemia and a novel ATM mutation. J Hum Genet. 2017;62:581-584 pubmed publisher
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| Sastre Moreno G, Pryor J, Moreno Oñate M, Herrero Ruiz A, Cortés Ledesma F, Blanco L, et al. Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining. DNA Repair (Amst). 2017;51:31-45 pubmed publisher
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| Moiseeva T, Gamper A, Hood B, Conrads T, Bakkenist C. Human DNA polymerase ? is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair (Amst). 2016;43:9-17 pubmed publisher
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| Beumer J, Fu K, Anyang B, Siegfried J, Bakkenist C. Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma. BMC Cancer. 2015;15:649 pubmed publisher
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| Zhou X, Tolstov Y, Arslan A, Roth W, Grüllich C, Pahernik S, et al. Harnessing the p53-PUMA axis to overcome DNA damage resistance in renal cell carcinoma. Neoplasia. 2014;16:1028-35 pubmed publisher
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| Cornell L, Munck J, Alsinet C, Villanueva A, Ogle L, Willoughby C, et al. DNA-PK-A candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival. Clin Cancer Res. 2015;21:925-33 pubmed publisher
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| Valcheva P, Cardus A, Panizo S, Parisi E, Bozic M, Lopez Novoa J, et al. Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals. Atherosclerosis. 2014;235:247-55 pubmed publisher
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| Zahn A, Eranki A, Patenaude A, Methot S, Fifield H, Cortizas E, et al. Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc Natl Acad Sci U S A. 2014;111:E988-97 pubmed publisher
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| Sakai H, Fujigaki H, Mazur S, Appella E. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. Cell Cycle. 2014;13:1015-29 pubmed publisher
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| Gamper A, Rofougaran R, Watkins S, Greenberger J, Beumer J, Bakkenist C. ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. Nucleic Acids Res. 2013;41:10334-44 pubmed publisher
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| Adelman C, Lolo R, Birkbak N, Murina O, Matsuzaki K, Horejsi Z, et al. HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature. 2013;502:381-4 pubmed publisher
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| Wu S, Chen T, Gmeiner W, Chu E, Schmitz J. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Res. 2013;41:4650-9 pubmed publisher
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| Zhang J, De Toledo S, Pandey B, Guo G, Pain D, Li H, et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A. 2012;109:E926-33 pubmed publisher
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| Viana Pereira M, Lee A, Popov S, Bax D, Al Sarraj S, Bridges L, et al. Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation. PLoS ONE. 2011;6:e20588 pubmed publisher
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| Tavecchio M, Munck J, Cano C, Newell D, Curtin N. Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination. Cancer Chemother Pharmacol. 2012;69:155-64 pubmed publisher
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| Munday D, Emmott E, Surtees R, Lardeau C, Wu W, Duprex W, et al. Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus. Mol Cell Proteomics. 2010;9:2438-59 pubmed publisher
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| Kibe T, Osawa G, Keegan C, de Lange T. Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010;30:1059-66 pubmed publisher
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| Goff J, Shields D, Seki M, Choi S, Epperly M, Dixon T, et al. Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation. Radiat Res. 2009;172:165-74 pubmed publisher
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| Delia D, Piane M, Buscemi G, Savio C, Palmeri S, Lulli P, et al. MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. Hum Mol Genet. 2004;13:2155-63 pubmed
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| Yang J, Yu Y, Hamrick H, Duerksen Hughes P. ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Carcinogenesis. 2003;24:1571-80 pubmed
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| Burma S, Chen B, Murphy M, Kurimasa A, Chen D. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem. 2001;276:42462-7 pubmed
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| Spring K, Cross S, Li C, Watters D, Ben Senior L, Waring P, et al. Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype. Cancer Res. 2001;61:4561-8 pubmed
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