Terzuoli E, Bellan C, Aversa S, Ciccone V, Morbidelli L, Giachetti A, et al. ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output. Cancers (Basel). 2019;11: pubmed publisher

Oliveira G, Ruggiero E, Stanghellini M, Cieri N, D Agostino M, D Agostino M, et al. Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory. Sci Transl Med. 2015;7:317ra198 pubmed publisher

Singh Y, Chen H, Zhou Y, Foller M, Mak T, Salker M, et al. Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells. Sci Rep. 2015;5:17723 pubmed publisher

Yan D, Farache J, Mingueneau M, Mathis D, Benoist C. Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3. Proc Natl Acad Sci U S A. 2015;112:14942-7 pubmed publisher

Brodeur T, Robidoux T, Weinstein J, Craft J, Swain S, Marshak Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. J Immunol. 2015;195:5251-60 pubmed publisher

Schellhorn M, Haustein M, Frank M, Linnebacher M, Hinz B. Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Oncotarget. 2015;6:39342-56 pubmed publisher

Deisting W, Raum T, Kufer P, Baeuerle P, Münz M. Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110. PLoS ONE. 2015;10:e0141669 pubmed publisher

Quatrini L, Molfetta R, Zitti B, Peruzzi G, Fionda C, Capuano C, et al. Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells. Sci Signal. 2015;8:ra108 pubmed publisher

Oh Y, Park H, Shin J, Lee J, Park H, Kho D, et al. Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2. Nat Commun. 2015;6:8698 pubmed publisher

Okita R, Shimizu K, Nojima Y, Yukawa T, Maeda A, Saisho S, et al. Lapatinib enhances trastuzumab-mediated antibody-dependent cellular cytotoxicity via upregulation of HER2 in malignant mesothelioma cells. Oncol Rep. 2015;34:2864-70 pubmed

Zhang Y, Tam J, Mena P, van der Velden A, Bliska J. CCR2+ Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8+ T Cell Response to the Protective YopE69-77 Epitope during Yersinia Infection. PLoS Pathog. 2015;11:e1005167 pubmed publisher

Salmond R, Brownlie R, Meyuhas O, Zamoyska R. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol. 2015;195:4615-22 pubmed publisher

Mazor R, Zhang J, Xiang L, Addissie S, Awuah P, Beers R, et al. Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors. Mol Cancer Ther. 2015;14:2789-96 pubmed publisher

Quast I, Keller C, Maurer M, Giddens J, Tackenberg B, Wang L, et al. Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity. J Clin Invest. 2015;125:4160-70 pubmed publisher

Kasahara T, Hygino J, Andrade R, Monteiro C, Sacramento P, Andrade A, et al. Poor functional immune recovery in aged HIV-1-infected patients following successfully treatment with antiretroviral therapy. Hum Immunol. 2015;76:701-10 pubmed publisher

Sanchez C, Baier C, Colle J, Chelbi R, Rihet P, Le Treut T, et al. Natural killer cells in patients with polycythemia vera. Hum Immunol. 2015;76:644-50 pubmed publisher

Ames E, Canter R, Grossenbacher S, Mac S, Smith R, Monjazeb A, et al. Enhanced targeting of stem-like solid tumor cells with radiation and natural killer cells. Oncoimmunology. 2015;4:e1036212 pubmed

Oldreive C, Skowronska A, Davies N, Parry H, Agathanggelou A, Krysov S, et al. T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice. Dis Model Mech. 2015;8:1401-12 pubmed publisher

Jahn J, Spielau M, Brandsch C, Stangl G, Delank K, Bähr I, et al. Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obesity (Silver Spring). 2015;23:2233-41 pubmed publisher

Kim J, Mathew S, Mathew P. Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells. Immunobiology. 2016;221:31-9 pubmed publisher

Issekutz A, Derfalvi B, Käsermann F, Rowter D. Potentiation of cytokine-induced proliferation of human Natural Killer cells by intravenous immunoglobulin G. Clin Immunol. 2015;161:373-83 pubmed publisher

Sakamoto N, Ishikawa T, Kokura S, Okayama T, Oka K, Ideno M, et al. Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer. J Transl Med. 2015;13:277 pubmed publisher

Masuda Y, Nawa D, Nakayama Y, Konishi M, Nanba H. Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity. J Leukoc Biol. 2015;98:1015-25 pubmed publisher

Hiyoshi M, Okuma K, Tateyama S, Takizawa K, Saito M, Kuramitsu M, et al. Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo. Retrovirology. 2015;12:73 pubmed publisher

Kim J, Balamurugan A, Azari K, Hofmann C, Ng H, Reed E, et al. Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand. PLoS ONE. 2015;10:e0136235 pubmed publisher

Zhang W, Smythe J, Frith E, Belfield H, Clarke S, Watt S, et al. An innovative method to generate a Good Manufacturing Practice-ready regulatory T-cell product from non-mobilized leukapheresis donors. Cytotherapy. 2015;17:1268-79 pubmed publisher

Niu P, Smagul A, Wang L, Sadvakas A, Sha Y, Pérez L, et al. Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence. Oncotarget. 2015;6:17938-57 pubmed

Sakaguchi S, Hainberger D, Tizian C, Tanaka H, Okuda T, Taniuchi I, et al. MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development. J Immunol. 2015;195:2879-87 pubmed publisher

Sumption N, Goodhead D, Anderson R. Alpha-Particle-Induced Complex Chromosome Exchanges Transmitted through Extra-Thymic Lymphopoiesis In Vitro Show Evidence of Emerging Genomic Instability. PLoS ONE. 2015;10:e0134046 pubmed publisher

Zou Y, Bao J, Pan X, Lu Y, Liao S, Wang X, et al. NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure. PLoS ONE. 2015;10:e0134568 pubmed publisher

Scoville S, Keller K, Cheng S, Zhang M, Zhang X, Caligiuri M, et al. Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues. Sci Rep. 2015;5:12490 pubmed publisher

Liang L, Zhang Z, Wang Y, Nong L, Zheng Y, Qu L, et al. The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type. Biomed Res Int. 2015;2015:435423 pubmed publisher

Godon O, Evlachev A, Bourgine M, Meritet J, Martin P, Inchauspe G, et al. Recognition of core-derived epitopes from a novel HBV-targeted immunotherapeutic by T-cells from patients infected by different viral genotypes. Vaccine. 2015;33:4548-53 pubmed publisher

Bai A, Kokkotou E, Zheng Y, Robson S. Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses. Cell Death Dis. 2015;6:e1828 pubmed publisher

Lisovsky I, Isitman G, Song R, DaFonseca S, Tremblay McLean A, Lebouché B, et al. A Higher Frequency of NKG2A+ than of NKG2A- NK Cells Responds to Autologous HIV-Infected CD4 Cells irrespective of Whether or Not They Coexpress KIR3DL1. J Virol. 2015;89:9909-19 pubmed publisher

Kelsen J, Dawany N, Moran C, Petersen B, Sarmady M, Sasson A, et al. Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease. Gastroenterology. 2015;149:1415-24 pubmed publisher

Pega J, Di Giacomo S, Bucafusco D, Schammas J, Malacari D, Barrionuevo F, et al. Systemic Foot-and-Mouth Disease Vaccination in Cattle Promotes Specific Antibody-Secreting Cells at the Respiratory Tract and Triggers Local Anamnestic Responses upon Aerosol Infection. J Virol. 2015;89:9581-90 pubmed publisher

Jang A, Song E, Shin S, Hwang P, Kim S, Jin Y, et al. Potentiation of natural killer (NK) cell activity by methanol extract of cultured cambial meristematic cells of wild ginseng and its mechanism. Life Sci. 2015;135:138-46 pubmed publisher

Schilbach K, Alkhaled M, Welker C, Eckert F, Blank G, Ziegler H, et al. Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation. Oncoimmunology. 2015;4:e1014760 pubmed

Pesce S, Tabellini G, Cantoni C, Patrizi O, Coltrini D, Rampinelli F, et al. B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape. Oncoimmunology. 2015;4:e1001224 pubmed

Kreymborg K, Haak S, Murali R, Wei J, Waitz R, Gasteiger G, et al. Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer. Cancer Immunol Res. 2015;3:849-54 pubmed publisher

Derouazi M, Di Berardino Besson W, Belnoue E, Hoepner S, Walther R, Benkhoucha M, et al. Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell-Mediated Antitumor Immunity. Cancer Res. 2015;75:3020-31 pubmed publisher

Mikucki M, Fisher D, Matsuzaki J, Skitzki J, Gaulin N, Muhitch J, et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nat Commun. 2015;6:7458 pubmed publisher

Capello M, Caorsi C, Bogantes Hernandez P, Dametto E, Bertinetto F, Magistroni P, et al. Phosphorylated alpha-enolase induces autoantibodies in HLA-DR8 pancreatic cancer patients and triggers HLA-DR8 restricted T-cell activation. Immunol Lett. 2015;167:11-6 pubmed publisher

Siernicka M, Winiarska M, Bajor M, Firczuk M, Muchowicz A, Bobrowicz M, et al. Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells. Immunology. 2015;146:173-83 pubmed publisher

Lu F, Yang W, Wang Y, Ma H, Tang W, Yang J, et al. Thymic B cells promote thymus-derived regulatory T cell development and proliferation. J Autoimmun. 2015;61:62-72 pubmed publisher

Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. 2015;463:739-45 pubmed publisher

Shafiee H, Kanakasabapathy M, Juillard F, Keser M, Sadasivam M, Yuksekkaya M, et al. Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva. Sci Rep. 2015;5:9919 pubmed publisher

Qin H, Cho M, Haso W, Zhang L, Tasian S, Oo H, et al. Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein. Blood. 2015;126:629-39 pubmed publisher

Zhang S, Bakshi R, Suneetha P, Fytili P, Antunes D, Vieira G, et al. Frequency, Private Specificity, and Cross-Reactivity of Preexisting Hepatitis C Virus (HCV)-Specific CD8+ T Cells in HCV-Seronegative Individuals: Implications for Vaccine Responses. J Virol. 2015;89:8304-17 pubmed publisher

Odorizzi P, Pauken K, Paley M, Sharpe A, Wherry E. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. J Exp Med. 2015;212:1125-37 pubmed publisher

García Gallego S, Díaz L, Jiménez J, Gómez R, de la Mata F, Muñoz Fernández M. HIV-1 antiviral behavior of anionic PPI metallo-dendrimers with EDA core. Eur J Med Chem. 2015;98:139-48 pubmed publisher

Martel B, Blom L, Dyring Andersen B, Skov L, Thestrup Pedersen K, Skov S, et al. Human Atopic Dermatitis Skin-derived T Cells can Induce a Reaction in Mouse Keratinocytes in vivo. Scand J Immunol. 2015;82:125-34 pubmed publisher

McLaren P, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge S, et al. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 2015;12:41 pubmed publisher

Borsa M, Ferreira P, Petry A, Ferreira L, Camargo M, Bou Habib D, et al. HIV infection and antiretroviral therapy lead to unfolded protein response activation. Virol J. 2015;12:77 pubmed publisher

Hwang S, Palin A, Li L, Song K, Lee J, Herz J, et al. TCR ITAM multiplicity is required for the generation of follicular helper T-cells. Nat Commun. 2015;6:6982 pubmed publisher

Mazzocco M, Martini M, Rosato A, Stefani E, Matucci A, Dalla Santa S, et al. Autologous cellular vaccine overcomes cancer immunoediting in a mouse model of myeloma. Immunology. 2015;146:33-49 pubmed publisher

Wojta Stremayr D, Neunkirchner A, Srinivasan B, Trapin D, Schmetterer K, Pickl W. CD8+ T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2. PLoS ONE. 2015;10:e0126034 pubmed publisher

Ueshima C, Kataoka T, Hirata M, Koyanagi I, Honda T, Tsuruyama T, et al. NKp46 regulates the production of serine proteases and IL-22 in human mast cells in urticaria pigmentosa. Exp Dermatol. 2015;24:675-9 pubmed publisher

Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, et al. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest. 2015;125:2347-62 pubmed publisher

Lampe K, Endale M, Cashman S, Fang H, Mattner J, Hildeman D, et al. Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets. Eur J Immunol. 2015;45:2072-83 pubmed publisher

Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, et al. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med. 2015;212:619-31 pubmed publisher

Litjens N, Boer K, Zuijderwijk J, Klepper M, Peeters A, Prens E, et al. Allogeneic Mature Human Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in the Presence of IL-15. J Immunol. 2015;194:5282-93 pubmed publisher

Liu B, Dhanda A, Hirani S, Williams E, Sen H, Martinez Estrada F, et al. CD14++CD16+ Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses. J Immunol. 2015;194:5150-60 pubmed publisher

Dyring Andersen B, Bonefeld C, Bzorek M, Løvendorf M, Lauritsen J, Skov L, et al. The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL-17+ T Cells in Psoriasis Lesions. Scand J Immunol. 2015;82:84-91 pubmed publisher

Hückelhoven A, Etschel J, Bergmann S, Zitzelsberger K, Mueller Schmucker S, Harrer E, et al. Cross-Reactivity Between Influenza Matrix- and HIV-1 P17-Specific CTL-A Large Cohort Study. J Acquir Immune Defic Syndr. 2015;69:528-35 pubmed publisher

Zhang J, Ren M, Zeng H, Guo Y, Zhuang Z, Feng Z, et al. Elevated follicular helper T cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves' disease. Immunol Res. 2015;62:163-74 pubmed publisher

Zhao P, Ma L, Ji H, Yu L, Feng J, Wang J, et al. The expression of TLR-9, CD86, and CD95 phenotypes in circulating B cells of patients with chronic viral hepatitis B or C before and after antiviral therapy. Mediators Inflamm. 2015;2015:762709 pubmed publisher

Lee S, Shin D, Kim S. Generation of recombinant canine interleukin-15 and evaluation of its effects on the proliferation and function of canine NK cells. Vet Immunol Immunopathol. 2015;165:1-13 pubmed publisher

Ramstead A, Schepetkin I, Todd K, Loeffelholz J, Berardinelli J, Quinn M, et al. Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B. Int Immunopharmacol. 2015;26:367-77 pubmed publisher

Liu L, Patel B, Ghanem M, Bundoc V, Zheng Z, Morgan R, et al. Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity. J Virol. 2015;89:6685-94 pubmed publisher

Aurisicchio L, Roscilli G, Marra E, Luberto L, Mancini R, La Monica N, et al. Superior Immunologic and Therapeutic Efficacy of a Xenogeneic Genetic Cancer Vaccine Targeting Carcinoembryonic Human Antigen. Hum Gene Ther. 2015;26:386-98 pubmed publisher

Taniguchi M, Ogiso H, Takeuchi T, Kitatani K, Umehara H, Okazaki T. Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis. Cell Death Dis. 2015;6:e1717 pubmed publisher

Wu Z, Frascaroli G, Bayer C, Schmal T, Mertens T. Interleukin-2 from Adaptive T Cells Enhances Natural Killer Cell Activity against Human Cytomegalovirus-Infected Macrophages. J Virol. 2015;89:6435-41 pubmed publisher

Nagahama K, Eto N, Shimojo T, Kondoh T, Nakahara K, Sakakibara Y, et al. Effect of kumquat (Fortunella crassifolia) pericarp on natural killer cell activity in vitro and in vivo. Biosci Biotechnol Biochem. 2015;79:1327-36 pubmed publisher

Che J, Selin L, Welsh R. Evaluation of non-reciprocal heterologous immunity between unrelated viruses. Virology. 2015;482:89-97 pubmed publisher

Schönberg K, Rudolph J, Vonnahme M, Parampalli Yajnanarayana S, Cornez I, Hejazi M, et al. JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms. Cancer Res. 2015;75:2187-99 pubmed publisher

Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. J Virol. 2015;89:5687-700 pubmed publisher

Ghosh S, Mukherjee S, Choudhury S, Gupta P, Adhikary A, Baral R, et al. Reactive oxygen species in the tumor niche triggers altered activation of macrophages and immunosuppression: Role of fluoxetine. Cell Signal. 2015;27:1398-412 pubmed publisher

Hebeisen M, Schmidt J, Guillaume P, Baumgaertner P, Speiser D, Luescher I, et al. Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells. Cancer Res. 2015;75:1983-91 pubmed publisher

Ahmed N, Brawley V, Hegde M, Robertson C, Ghazi A, Gerken C, et al. Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma. J Clin Oncol. 2015;33:1688-96 pubmed publisher

Geng D, Kaczanowska S, TSAI A, Younger K, Ochoa A, Rapoport A, et al. TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity. Cancer Res. 2015;75:1959-1971 pubmed publisher

Tian X, Zhang A, Qiu C, Wang W, Yang Y, Qiu C, et al. The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. J Immunol. 2015;194:3873-82 pubmed publisher

House I, Thia K, Brennan A, Tothill R, Dobrovic A, Yeh W, et al. Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals. Immunol Cell Biol. 2015;93:575-80 pubmed publisher

Sarhan D, Palma M, Mao Y, Adamson L, Kiessling R, Mellstedt H, et al. Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β. Eur J Immunol. 2015;45:1783-93 pubmed publisher

Telwatte S, Hearps A, Johnson A, Latham C, Moore K, Agius P, et al. Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations. Nucleic Acids Res. 2015;43:3256-71 pubmed publisher

Won T, Lee Y, Hyung K, Yang E, Sohn U, Min H, et al. SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⁺ T cells in mice. Cell Signal. 2015;27:1246-52 pubmed publisher

Liu J, Gaj T, Wallen M, Barbas C. Improved cell-penetrating zinc-finger nuclease proteins for precision genome engineering. Mol Ther Nucleic Acids. 2015;4:e232 pubmed publisher

Ip P, Boerma A, Walczak M, Oosterhuis K, Haanen J, Schumacher T, et al. Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines. Gene Ther. 2015;22:560-7 pubmed publisher

de Andrade Pereira B, Ackermann M, Chaudhary S, Vogel R, Vogt B, Dresch C, et al. Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells. Gene Ther. 2015;22:382-90 pubmed publisher

Guo H, Zhang H, Lu L, Ezzelarab M, Thomson A. Generation, cryopreservation, function and in vivo persistence of ex vivo expanded cynomolgus monkey regulatory T cells. Cell Immunol. 2015;295:19-28 pubmed publisher

Morin S, Giroux V, Favre C, Bechah Y, Auphan Anezin N, Roncagalli R, et al. In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation. Cell Mol Life Sci. 2015;72:2739-48 pubmed publisher

Edri Brami M, Sharoni H, Hayoun D, Skutelsky L, Nemirovsky A, Porgador A, et al. Development of stage-dependent glycans on the Fc domains of IgG antibodies of ALS animals. Exp Neurol. 2015;267:95-106 pubmed publisher

Kefalakes H, Budeus B, Walker A, Jochum C, Hilgard G, Heinold A, et al. Adaptation of the hepatitis B virus core protein to CD8(+) T-cell selection pressure. Hepatology. 2015;62:47-56 pubmed publisher

Fenoglio D, Parodi A, Lavieri R, Kalli F, Ferrera F, Tagliamacco A, et al. Immunogenicity of GX301 cancer vaccine: Four (telomerase peptides) are better than one. Hum Vaccin Immunother. 2015;11:838-50 pubmed publisher

Seidel D, Shibina A, Siebert N, Wels W, Reynolds C, Huebener N, et al. Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma. Cancer Immunol Immunother. 2015;64:621-34 pubmed publisher

Severson J, Serracino H, Mateescu V, Raeburn C, McIntyre R, Sams S, et al. PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res. 2015;3:620-30 pubmed publisher

Li G, Wu K, Tao K, Lu X, Ma J, Mao Z, et al. Vasoactive intestinal peptide induces CD14+HLA-DR‑/low myeloid-derived suppressor cells in gastric cancer. Mol Med Rep. 2015;12:760-8 pubmed publisher

Pereboeva L, Harkins L, Wong S, Lamb L. The safety of allogeneic innate lymphocyte therapy for glioma patients with prior cranial irradiation. Cancer Immunol Immunother. 2015;64:551-62 pubmed publisher

Kim D, Lee Y, Park H, Lee J, Kim H, Hwang J, et al. Piceatannol inhibits effector T cell functions by suppressing TcR signaling. Int Immunopharmacol. 2015;25:285-92 pubmed publisher

Jha S, Chakraborty N, Singh P, Mukherji B, Dorsky D. Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+)  CD25(-) and CD8(+) T cells attenuates effector function. Immunology. 2015;145:124-35 pubmed publisher

Garcia Alonso M, Caballero M, Umpierrez A, Lluch Bernal M, Knaute T, Rodriguez Perez R. Relationships between T cell and IgE/IgG4 epitopes of the Anisakis simplex major allergen Ani s 1. Clin Exp Allergy. 2015;45:994-1005 pubmed publisher

Bengs S, Marttila J, Susi P, Ilonen J. Elicitation of T-cell responses by structural and non-structural proteins of coxsackievirus B4. J Gen Virol. 2015;96:322-30 pubmed publisher

Santegoets K, Wenink M, van den Berg W, Radstake T. Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals. PLoS ONE. 2014;9:e110966 pubmed publisher

Ardolino M, Azimi C, Iannello A, Trevino T, Horan L, Zhang L, et al. Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. J Clin Invest. 2014;124:4781-94 pubmed publisher

Rygh C, Wang J, Thuen M, Gras Navarro A, Huuse E, Thorsen F, et al. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLoS ONE. 2014;9:e108414 pubmed publisher

Ren Y, Yang B, Yin Y, Leng X, Jiang Y, Zhang L, et al. Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis. Rheumatology (Oxford). 2015;54:712-21 pubmed publisher

Coffey G, Betz A, DeGuzman F, Pak Y, Inagaki M, Baker D, et al. The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer. J Pharmacol Exp Ther. 2014;351:538-48 pubmed publisher

Purdy A, Alvarez Arias D, Oshinsky J, James A, Serebriiskii I, Campbell K. The ap-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor in human NK cells. J Immunol. 2014;193:4675-83 pubmed publisher

Kurktschiev P, Raziorrouh B, Schraut W, Backmund M, Wächtler M, Wendtner C, et al. Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction. J Exp Med. 2014;211:2047-59 pubmed publisher

Venner J, Famulski K, Badr D, Hidalgo L, Chang J, Halloran P. Molecular landscape of T cell-mediated rejection in human kidney transplants: prominence of CTLA4 and PD ligands. Am J Transplant. 2014;14:2565-76 pubmed publisher

Ban S, Salzer E, Eibl M, Linder A, Geier C, Santos Valente E, et al. Combined immunodeficiency evolving into predominant CD4+ lymphopenia caused by somatic chimerism in JAK3. J Clin Immunol. 2014;34:941-53 pubmed publisher

Mata M, Vera J, Gerken C, Rooney C, Miller T, Pfent C, et al. Toward immunotherapy with redirected T cells in a large animal model: ex vivo activation, expansion, and genetic modification of canine T cells. J Immunother. 2014;37:407-15 pubmed publisher

Côté Maurais G, Bernier J. Silver and fullerene nanoparticles' effect on interleukin-2-dependent proliferation of CD4 (+) T cells. Toxicol In Vitro. 2014;28:1474-81 pubmed publisher

Wang J, Nanjundappa R, Shameli A, Clemente Casares X, Yamanouchi J, Elliott J, et al. The cross-priming capacity and direct presentation potential of an autoantigen are separable and inversely related properties. J Immunol. 2014;193:3296-307 pubmed publisher

Poh C, Howland S, Grotenbreg G, Rénia L. Damage to the blood-brain barrier during experimental cerebral malaria results from synergistic effects of CD8+ T cells with different specificities. Infect Immun. 2014;82:4854-64 pubmed publisher

Kim S, Chung H, Lee K, Lim J. Identification of novel epitopes from human papillomavirus type 18 E7 that can sensitize PBMCs of multiple HLA class I against human cervical cancer. J Transl Med. 2014;12:229 pubmed publisher

Au Yeung B, Zikherman J, Mueller J, Ashouri J, Matloubian M, Cheng D, et al. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014;111:E3679-88 pubmed publisher

Chudley L, McCann K, Coleman A, Cazaly A, Bidmon N, Britten C, et al. Harmonisation of short-term in vitro culture for the expansion of antigen-specific CD8(+) T cells with detection by ELISPOT and HLA-multimer staining. Cancer Immunol Immunother. 2014;63:1199-211 pubmed publisher

Comerford R, Coates C, Byrne G, Lynch S, Dunne P, Dunne M, et al. Characterisation of tissue transglutaminase-reactive T cells from patients with coeliac disease and healthy controls. Clin Immunol. 2014;154:155-63 pubmed publisher

Ohue Y, Kurose K, Mizote Y, Matsumoto H, Nishio Y, Isobe M, et al. Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody. Clin Cancer Res. 2014;20:5052-63 pubmed publisher

Macleod B, Bedoui S, Hor J, Mueller S, Russell T, Hollett N, et al. Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1. PLoS Pathog. 2014;10:e1004303 pubmed publisher

Bending D, Pesenacker A, Ursu S, Wu Q, Lom H, Thirugnanabalan B, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis. J Immunol. 2014;193:2699-708 pubmed publisher

Yu K, Lee J, Kim H, Hong I, Choi S, Seo Y, et al. A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging. PLoS ONE. 2014;9:e102426 pubmed publisher

Malecek K, Grigoryan A, Zhong S, Gu W, Johnson L, Rosenberg S, et al. Specific increase in potency via structure-based design of a TCR. J Immunol. 2014;193:2587-99 pubmed publisher

Beverley P, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, et al. A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis. J Immunol. 2014;193:2306-16 pubmed publisher

Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, et al. IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages. J Pharmacol Sci. 2014;125:394-405 pubmed

Dehò L, Leoni C, Brodie T, Montagner S, De Simone M, Polletti S, et al. Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities. J Immunol. 2014;193:2196-206 pubmed publisher

Arenaccio C, Chiozzini C, Columba Cabezas S, Manfredi F, Affabris E, Baur A, et al. Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism. J Virol. 2014;88:11529-39 pubmed publisher

Rubio N, Arevalo M, Cerciat M, Sanz Rodriguez F, Unkila M, Garcia Segura L. Theiler's virus infection provokes the overexpression of genes coding for the chemokine Ip10 (CXCL10) in SJL/J murine astrocytes, which can be inhibited by modulators of estrogen receptors. J Neurovirol. 2014;20:485-95 pubmed publisher

Zhao C, Shi G, Vistica B, Hinshaw S, Wandu W, Tan C, et al. Induced regulatory T-cells (iTregs) generated by activation with anti-CD3/CD28 antibodies differ from those generated by the physiological-like activation with antigen/APC. Cell Immunol. 2014;290:179-84 pubmed publisher

Shen Y, Liu Q, Luo Y, Zhang P, Bai F, Cheng S, et al. Enhancement of the cytotoxic activity of cytokine-induced killer cells transfected with IL3PE38KDEL gene against acute myeloid leukemia cells. Ann Hematol. 2014;93:2019-28 pubmed publisher

Wu L, Wang C, Boisson B, Misra S, Rayman P, Finke J, et al. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling. J Immunol. 2014;193:1590-9 pubmed publisher

Palmer C, Ninkovic J, Prokopowicz Z, Mancuso C, Marin A, Andrianov A, et al. The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells. Biomaterials. 2014;35:8876-8886 pubmed publisher

Leuenberger T, Pfueller C, Luessi F, Bendix I, Paterka M, Prozorovski T, et al. Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. PLoS ONE. 2014;9:e100871 pubmed publisher

Otsuki H, Yoneda M, Igarashi T, Miura T. Generation of a monkey-tropic human immunodeficiency virus type 1 carrying env from a CCR5-tropic subtype C clinical isolate. Virology. 2014;460-461:1-10 pubmed publisher

Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, et al. Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS ONE. 2014;9:e101655 pubmed publisher

Martinelli R, Zeiger A, Whitfield M, Sciuto T, Dvorak A, Van Vliet K, et al. Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance. J Cell Sci. 2014;127:3720-34 pubmed publisher

Takahashi R, Yamagishi M, Nakano K, Yamochi T, Yamochi T, Fujikawa D, et al. Epigenetic deregulation of Ellis Van Creveld confers robust Hedgehog signaling in adult T-cell leukemia. Cancer Sci. 2014;105:1160-9 pubmed publisher

Wang H, Yang B, Chi X, Cai L, Yu R, Zhu H, et al. Ultra-low-dose decitabine combined with autologous cytokine-induced killer cells for elderly patients with acute myeloid leukemia transformed from myelodysplastic syndrome. Clin Ther. 2014;36:1104-11 pubmed publisher

Madireddi S, Eun S, Lee S, Nemčovičová I, Mehta A, Zajonc D, et al. Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. J Exp Med. 2014;211:1433-48 pubmed publisher

GUERRERO A, Dong M, Zhao Y, Lau Kilby A, Tarbell K. Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors. Immunology. 2014;143:640-50 pubmed publisher

Gao N, Dresel J, Eckstein V, Gellert R, Störch H, Venigalla R, et al. Impaired suppressive capacity of activation-induced regulatory B cells in systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:2849-61 pubmed publisher

Volpe E, Pattarini L, Martinez Cingolani C, Meller S, Donnadieu M, Bogiatzi S, et al. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol. 2014;134:373-81 pubmed publisher

Meager A, Wadhwa M. Detection of anti-cytokine antibodies and their clinical relevance. Expert Rev Clin Immunol. 2014;10:1029-47 pubmed publisher

Pretto F, Elia G, Castioni N, Neri D. Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy. Cancer Immunol Immunother. 2014;63:901-10 pubmed publisher

Zhu S, Phatarpekar P, Denman C, Senyukov V, Somanchi S, Nguyen Jackson H, et al. Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation. Blood. 2014;124:403-11 pubmed publisher

Wang H, Wang Y, Jiang X, Wang Z, Zhong B, Fang Y. The molecular mechanism of curcumol on inducing cell growth arrest and apoptosis in Jurkat cells, a model of CD4⁺ T cells. Int Immunopharmacol. 2014;21:375-82 pubmed publisher

Kleijn A, Kloezeman J, Treffers Westerlaken E, Fulci G, Leenstra S, Dirven C, et al. The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity. PLoS ONE. 2014;9:e97495 pubmed publisher

Molfetta R, Quatrini L, Capuano C, Gasparrini F, Zitti B, Zingoni A, et al. c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells. Eur J Immunol. 2014;44:2761-70 pubmed publisher

Traitanon O, Gorbachev A, Bechtel J, Keslar K, Baldwin W, Poggio E, et al. IL-15 induces alloreactive CD28(-) memory CD8 T cell proliferation and CTLA4-Ig resistant memory CD8 T cell activation. Am J Transplant. 2014;14:1277-89 pubmed publisher

Geffner L, Basile J, Yokobori N, Kviatcovsky D, Sabio Y García C, Ritacco V, et al. Mycobacterium tuberculosis multidrug resistant strain M induces an altered activation of cytotoxic CD8+ T cells. PLoS ONE. 2014;9:e97837 pubmed publisher

Valente M, Baey C, Louche P, Dutertre C, Vimeux L, Marañon C, et al. Apoptotic cell capture by DCs induces unexpectedly robust autologous CD4+ T-cell responses. Eur J Immunol. 2014;44:2274-86 pubmed publisher

Li R, Qian J, Zhang W, Fu W, Du J, Jiang H, et al. Human heat shock protein-specific cytotoxic T lymphocytes display potent antitumour immunity in multiple myeloma. Br J Haematol. 2014;166:690-701 pubmed publisher

Breman E, van Miert P, van der Steen D, Heemskerk M, Doxiadis I, Roelen D, et al. HLA monomers as a tool to monitor indirect allorecognition. Transplantation. 2014;97:1119-27 pubmed publisher

Freeman M, Roberts A, Burkum C, Woodland D, Blackman M. Promotion of a subdominant CD8 T cell response during murine gammaherpesvirus 68 infection in the absence of CD4 T cell help. J Virol. 2014;88:7862-9 pubmed publisher

Leipe J, Schramm M, Prots I, Schulze Koops H, Skapenko A. Increased Th17 cell frequency and poor clinical outcome in rheumatoid arthritis are associated with a genetic variant in the IL4R gene, rs1805010. Arthritis Rheumatol. 2014;66:1165-75 pubmed publisher

Cecil D, Holt G, Park K, Gad E, Rastetter L, Childs J, et al. Elimination of IL-10-inducing T-helper epitopes from an IGFBP-2 vaccine ensures potent antitumor activity. Cancer Res. 2014;74:2710-8 pubmed publisher

Lettau M, Kliche S, Kabelitz D, Janssen O. The adapter proteins ADAP and Nck cooperate in T cell adhesion. Mol Immunol. 2014;60:72-9 pubmed publisher

Tong Q, He S, Xie F, Mochizuki K, Liu Y, Mochizuki I, et al. Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice. J Immunol. 2014;192:5012-22 pubmed publisher

Wang D, Feng X, Lu L, Konkel J, Zhang H, Chen Z, et al. A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:2234-45 pubmed publisher

Kizima L, Rodriguez A, Kenney J, Derby N, Mizenina O, Menon R, et al. A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV. PLoS ONE. 2014;9:e94547 pubmed publisher

Drewes J, Szeto G, Engle E, Liao Z, Shearer G, Zink M, et al. Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline. PLoS ONE. 2014;9:e94375 pubmed publisher

Roider J, Meissner T, Kraut F, Vollbrecht T, Stirner R, Bogner J, et al. Comparison of experimental fine-mapping to in silico prediction results of HIV-1 epitopes reveals ongoing need for mapping experiments. Immunology. 2014;143:193-201 pubmed publisher

Hosoi H, Ikeda H, Imai N, Amaike C, Wang L, Orito Y, et al. Stimulation through very late antigen-4 and -5 improves the multifunctionality and memory formation of CD8⁺ T cells. Eur J Immunol. 2014;44:1747-58 pubmed publisher

Mishra S, Losikoff P, Self A, Terry F, Ardito M, Tassone R, et al. Peptide-pulsed dendritic cells induce the hepatitis C viral epitope-specific responses of naïve human T cells. Vaccine. 2014;32:3285-92 pubmed publisher

Choi B, Lee S, Lee M, Kim Y, Kim Y, Ryu K, et al. 4-1BB-based isolation and expansion of CD8+ T cells specific for self-tumor and non-self-tumor antigens for adoptive T-cell therapy. J Immunother. 2014;37:225-36 pubmed publisher

Perez Cunningham J, Ames E, Smith R, Peter A, Naidu R, Nolta J, et al. Natural killer cell subsets differentially reject embryonic stem cells based on licensing. Transplantation. 2014;97:992-8 pubmed publisher

Ruan M, Thorn K, Liu S, Li S, Yang W, Zhang C, et al. The secretion of IL-6 by CpG-ODN-treated cancer cells promotes T-cell immune responses partly through the TLR-9/AP-1 pathway in oral squamous cell carcinoma. Int J Oncol. 2014;44:2103-10 pubmed publisher

Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, et al. Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol. 2014;44:2175-87 pubmed publisher

God J, Zhao D, Cameron C, Amria S, Bethard J, Haque A. Disruption of HLA class II antigen presentation in Burkitt lymphoma: implication of a 47,000 MW acid labile protein in CD4+ T-cell recognition. Immunology. 2014;142:492-505 pubmed publisher

Guma S, Lee D, Ling Y, Gordon N, Kleinerman E. Aerosol interleukin-2 induces natural killer cell proliferation in the lung and combination therapy improves the survival of mice with osteosarcoma lung metastasis. Pediatr Blood Cancer. 2014;61:1362-8 pubmed publisher

Fujiyama T, Ito T, Ogawa N, Suda T, Tokura Y, Hashizume H. Preferential infiltration of interleukin-4-producing CXCR4+ T cells in the lesional muscle but not skin of patients with dermatomyositis. Clin Exp Immunol. 2014;177:110-20 pubmed publisher

Holder B, Grant C, Liberal R, Ma Y, Heneghan M, Mieli Vergani G, et al. Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2. J Autoimmun. 2014;53:26-32 pubmed publisher

Kim E, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N. Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 ? chain on T cells, abrogating alloreactive T cells. Immunology. 2014;142:421-30 pubmed publisher

Jourdan M, Cren M, Robert N, Bollore K, Fest T, Duperray C, et al. IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors. Leukemia. 2014;28:1647-56 pubmed publisher

Van Raemdonck K, Gouwy M, Lepers S, Van Damme J, Struyf S. CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase. Angiogenesis. 2014;17:631-40 pubmed publisher

McCarthy S, Jung D, Sakac D, Branch D. c-Src and Pyk2 protein tyrosine kinases play protective roles in early HIV-1 infection of CD4+ T-cell lines. J Acquir Immune Defic Syndr. 2014;66:118-26 pubmed publisher

Xie B, Yang J, Li H, Zhang B, Chen W, Zhou B, et al. Dendritic cells transfected with hepatocellular carcinoma (HCC) total RNA induce specific immune responses against HCC in vitro and in vivo. Clin Transl Oncol. 2014;16:753-60 pubmed publisher

Ortiz V, Wands J. Chronic ethanol diet increases regulatory T-cell activity and inhibits hepatitis C virus core-specific cellular immune responses in mice. Hepatol Res. 2014;44:788-97 pubmed publisher

Jacobs S, Plessers J, Pinxteren J, Roobrouck V, Verfaillie C, Van Gool S. Mutual interaction between human multipotent adult progenitor cells and NK cells. Cell Transplant. 2014;23:1099-110 pubmed publisher

Smith K. Interleukin 2. Annu Rev Immunol. 1984;2:319-33 pubmed

Robb R, Kutny R, Panico M, Morris H, Chowdhry V. Amino acid sequence and post-translational modification of human interleukin 2. Proc Natl Acad Sci U S A. 1984;81:6486-90 pubmed