Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577:676-681 pubmed publisher

Murata H, Takamatsu H, Liu S, Kataoka K, Huh N, Sakaguchi M. NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions. PLoS ONE. 2015;10:e0142438 pubmed publisher

Nie S, Xu Y, Chen G, Ma K, Han C, Guo Z, et al. Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents. Neuropharmacology. 2015;99:448-58 pubmed publisher

Mao S, Sun Q, Xiao H, Zhang C, Li L. Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2. Protein Cell. 2015;6:529-540 pubmed publisher

Bagga V, Dunnett S, Fricker R. The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions. Behav Brain Res. 2015;288:107-17 pubmed publisher

Melief E, Cudaback E, Jorstad N, Sherfield E, Postupna N, Wilson A, et al. Partial depletion of striatal dopamine enhances penetrance of cognitive deficits in a transgenic mouse model of Alzheimer's disease. J Neurosci Res. 2015;93:1413-22 pubmed publisher

Gálosi R, Hajnal A, Petykó Z, Hartmann G, Karádi Z, Lénárd L. The role of catecholamine innervation in the medial prefrontal cortex on the regulation of body weight and food intake. Behav Brain Res. 2015;286:318-27 pubmed publisher

Horvathova L, Tillinger A, Sivakova I, Mikova L, Mravec B, Bucova M. Chemical sympathectomy increases neutrophil-to-lymphocyte ratio in tumor-bearing rats but does not influence cancer progression. J Neuroimmunol. 2015;278:255-61 pubmed publisher

Jarillo Luna R, Rivera Aguilar V, Pacheco Yépez J, Godínez Victoria M, Oros Pantoja R, Miliar García A, et al. Nasal IgA secretion in a murine model of acute stress. The possible role of catecholamines. J Neuroimmunol. 2015;278:223-31 pubmed publisher

Wu C, Chang S, Lin C, Huang L, Tsai C. Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease: involvement of antioxidative enzymes induction. Chem Biol Interact. 2015;225:40-6 pubmed publisher

Zheng K, Iqbal S, Hernandez P, Park H, LoGrasso P, Feng Y. Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives. J Med Chem. 2014;57:10013-30 pubmed publisher

Bordia T, McGregor M, Papke R, Decker M, McIntosh J, Quik M. The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Exp Neurol. 2015;263:277-84 pubmed publisher

Lindenbach D, Palumbo N, Ostock C, Vilceus N, Conti M, Bishop C. Side effect profile of 5-HT treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats. Br J Pharmacol. 2015;172:119-30 pubmed publisher

Park H, Kang Y, Kang Y, Park T, Ryu Y, Hwang J, et al. Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease. J Neurosci. 2014;34:11744-53 pubmed publisher

Romaní Aumedes J, Canal M, Martín Flores N, Sun X, Perez Fernandez V, Wewering S, et al. Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease. Cell Death Dis. 2014;5:e1364 pubmed publisher

Barnum C, Chen X, Chung J, Chang J, Williams M, Grigoryan N, et al. Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats. J Parkinsons Dis. 2014;4:349-60 pubmed publisher

Hou J, Liu Q, Li Y, Sun H, Zhang J. An in vivo microdialysis study of FLZ penetration through the blood-brain barrier in normal and 6-hydroxydopamine induced Parkinson's disease model rats. Biomed Res Int. 2014;2014:850493 pubmed publisher

Tatenhorst L, Tönges L, Saal K, Koch J, Szego E, Bahr M, et al. Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease. J Neuropathol Exp Neurol. 2014;73:770-9 pubmed publisher

Kunori N, Kajiwara R, Takashima I. Voltage-sensitive dye imaging of primary motor cortex activity produced by ventral tegmental area stimulation. J Neurosci. 2014;34:8894-903 pubmed publisher

Zhang N, Shu H, Huang T, Zhang Q, Li D, Zhang G, et al. Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity. PLoS ONE. 2014;9:e100286 pubmed publisher

Cass W, Peters L, Fletcher A, Yurek D. Calcitriol promotes augmented dopamine release in the lesioned striatum of 6-hydroxydopamine treated rats. Neurochem Res. 2014;39:1467-76 pubmed publisher

Shah M, Rajagopalan S, Xu L, Voshavar C, Shurubor Y, Beal F, et al. The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease. J Neurochem. 2014;131:74-85 pubmed publisher

Hu L, Yen J, Shen Y, Wu K, Wu M. Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells. PLoS ONE. 2014;9:e97880 pubmed publisher

Patel V, Chu C. Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease. Exp Neurol. 2014;257:170-81 pubmed publisher

Navailles S, Milan L, Khalki H, Di Giovanni G, Lagière M, De Deurwaerdère P. Noradrenergic terminals regulate L-DOPA-derived dopamine extracellular levels in a region-dependent manner in Parkinsonian rats. CNS Neurosci Ther. 2014;20:671-8 pubmed publisher

Francardo V, Bez F, Wieloch T, Nissbrandt H, Ruscher K, Cenci M. Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism. Brain. 2014;137:1998-2014 pubmed publisher

Oeckl P, Hengerer B, Ferger B. G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Exp Neurol. 2014;257:1-9 pubmed publisher

Shin E, Rogers J, Devoto P, Bjorklund A, Carta M. Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease. Exp Neurol. 2014;257:25-38 pubmed publisher

Suzuki H, Ono K, Sawada M. Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection. J Neural Transm (Vienna). 2014;121:1349-55 pubmed publisher

Sedaghat R, Roghani M, Khalili M. Neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model. Iran J Pharm Res. 2014;13:227-34 pubmed

Czech D, Lee J, Correia J, Loke H, Möller E, Harley V. Transient neuroprotection by SRY upregulation in dopamine cells following injury in males. Endocrinology. 2014;155:2602-12 pubmed publisher

Karuppagounder S, Bhattacharya D, Ahuja M, Suppiramaniam V, Deruiter J, Clark R, et al. Elucidating the neurotoxic effects of MDMA and its analogs. Life Sci. 2014;101:37-42 pubmed publisher

Kim W, Lee Y, McKenna N, Yi M, Simunovic F, Wang Y, et al. miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling. Neurobiol Aging. 2014;35:1712-21 pubmed publisher

Villar Cheda B, Dominguez Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira Garcia J. Aging-related dysregulation of dopamine and angiotensin receptor interaction. Neurobiol Aging. 2014;35:1726-38 pubmed publisher

Suzuki Y, Shimizu H, Ishizuka N, Kubota N, Kubota T, Senoo A, et al. Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release. Diabetes. 2014;63:1637-48 pubmed publisher

Zhang X, Feng Z, Chergui K. GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease. J Neurochem. 2014;129:581-90 pubmed publisher

Song J, Zheng L, Zhang X, Feng X, Fan R, Sun L, et al. Upregulation of ?1-adrenoceptors is involved in the formation of gastric dysmotility in the 6-hydroxydopamine rat model of Parkinson's disease. Transl Res. 2014;164:22-31 pubmed publisher

Yoon H, Park J, Kim Y, Min J, Hwang E, Lee C, et al. Optogenetic inactivation of the subthalamic nucleus improves forelimb akinesia in a rat model of Parkinson disease. Neurosurgery. 2014;74:533-40; discussion 540-1 pubmed publisher

Salvatore M. ser31 Tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion. J Neurochem. 2014;129:548-58 pubmed publisher

Lin L, Moore S, Jones S, McGlashon J, Talman W. Astrocytes in the rat nucleus tractus solitarii are critical for cardiovascular reflex control. J Neurosci. 2013;33:18608-17 pubmed publisher

Liu Y, Peng M, Zang D, Zhang B. Leukemia inhibitory factor promotes nestin-positive cells, and increases gp130 levels in the Parkinson disease mouse model of 6-hydroxydopamine. Neurosciences (Riyadh). 2013;18:363-70 pubmed

Schmitz Y, Castagna C, Mrejeru A, Lizardi Ortiz J, Klein Z, Lindsley C, et al. Glycine transporter-1 inhibition promotes striatal axon sprouting via NMDA receptors in dopamine neurons. J Neurosci. 2013;33:16778-89 pubmed publisher

Kucinski A, Paolone G, Bradshaw M, Albin R, Sarter M. Modeling fall propensity in Parkinson's disease: deficits in the attentional control of complex movements in rats with cortical-cholinergic and striatal-dopaminergic deafferentation. J Neurosci. 2013;33:16522-39 pubmed publisher

Haddadi R, Mohajjel Nayebi A, Brooshghalan S. Pre-treatment with silymarin reduces brain myeloperoxidase activity and inflammatory cytokines in 6-OHDA hemi-parkinsonian rats. Neurosci Lett. 2013;555:106-11 pubmed publisher

Chu C, Ji J, Dagda R, Jiang J, Tyurina Y, Kapralov A, et al. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol. 2013;15:1197-1205 pubmed publisher

Chetrit J, Taupignon A, Froux L, Morin S, Bouali Benazzouz R, Naudet F, et al. Inhibiting subthalamic D5 receptor constitutive activity alleviates abnormal electrical activity and reverses motor impairment in a rat model of Parkinson's disease. J Neurosci. 2013;33:14840-9 pubmed publisher

Wang M, Tanida M, Shibamoto T, Kurata Y. Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2013;305:R900-7 pubmed publisher

Meesarapee B, Thampithak A, Jaisin Y, Sanvarinda P, Suksamrarn A, Tuchinda P, et al. Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells. Phytother Res. 2014;28:611-6 pubmed publisher

Prinz A, Selesnew L, Liss B, Roeper J, Carlsson T. Increased excitability in serotonin neurons in the dorsal raphe nucleus in the 6-OHDA mouse model of Parkinson's disease. Exp Neurol. 2013;248:236-45 pubmed publisher

Lindemann C, Alam M, Krauss J, Schwabe K. Neuronal activity in the medial associative-limbic and lateral motor part of the rat subthalamic nucleus and the effect of 6-hydroxydopamine-induced lesions of the dorsolateral striatum. J Comp Neurol. 2013;521:3226-40 pubmed publisher

Pienaar I, van de Berg W. A non-cholinergic neuronal loss in the pedunculopontine nucleus of toxin-evoked parkinsonian rats. Exp Neurol. 2013;248:213-23 pubmed publisher

Ren X, Zhang T, Gong X, Hu G, Ding W, Wang X. AAV2-mediated striatum delivery of human CDNF prevents the deterioration of midbrain dopamine neurons in a 6-hydroxydopamine induced parkinsonian rat model. Exp Neurol. 2013;248:148-56 pubmed publisher

Ciucci M, Schaser A, Russell J. Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease. Behav Brain Res. 2013;252:239-45 pubmed publisher

Tripanichkul W, Jaroensuppaperch E. Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice. Eur Rev Med Pharmacol Sci. 2013;17:1360-8 pubmed

Worlitzer M, Viel T, Jacobs A, Schwamborn J. The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation. Eur J Neurosci. 2013;38:2684-92 pubmed publisher

Ouachikh O, Dieb W, Durif F, Hafidi A. Differential behavioral reinforcement effects of dopamine receptor agonists in the rat with bilateral lesion of the posterior ventral tegmental area. Behav Brain Res. 2013;252:24-31 pubmed publisher

Petri D, Pum M, Vesper J, Huston J, Schnitzler A. GABAA-receptor activation in the subthalamic nucleus compensates behavioral asymmetries in the hemiparkinsonian rat. Behav Brain Res. 2013;252:58-67 pubmed publisher

Blandino P, Hueston C, Barnum C, Bishop C, Deak T. The impact of ventral noradrenergic bundle lesions on increased IL-1 in the PVN and hormonal responses to stress in male sprague dawley rats. Endocrinology. 2013;154:2489-500 pubmed publisher

Tovilovic G, Zogovic N, Soskic V, Schrattenholz A, Kostic Rajacic S, Misirkic Marjanovic M, et al. Arylpiperazine-mediated activation of Akt protects SH-SY5Y neuroblastoma cells from 6-hydroxydopamine-induced apoptotic and autophagic death. Neuropharmacology. 2013;72:224-35 pubmed publisher

Carvalho M, Campos F, Coimbra B, Pêgo J, Rodrigues C, Lima R, et al. Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits. Mol Neurodegener. 2013;8:14 pubmed publisher

Chen H, Li F, Li X, Liu B, Qu F, Wen W, et al. Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms. Stress. 2013;16:557-63 pubmed publisher

Chong C, Zhou Z, Razmovski Naumovski V, Cui G, Zhang L, Sa F, et al. Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Neurosci Lett. 2013;543:121-5 pubmed publisher

Chaudhry Z, Ahmed B. Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells. Neurol Res. 2013;35:435-40 pubmed publisher

Frau L, Morelli M, Simola N. Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons. Exp Neurol. 2013;247:663-72 pubmed publisher

López Huerta V, Carrillo Reid L, Galarraga E, Tapia D, Fiordelisio T, Drucker Colín R, et al. The balance of striatal feedback transmission is disrupted in a model of parkinsonism. J Neurosci. 2013;33:4964-75 pubmed publisher

Hernandez L, Kubota Y, Hu D, Howe M, Lemaire N, Graybiel A. Selective effects of dopamine depletion and L-DOPA therapy on learning-related firing dynamics of striatal neurons. J Neurosci. 2013;33:4782-95 pubmed publisher

Reinhardt P, Schmid B, Burbulla L, Schöndorf D, Wagner L, Glatza M, et al. Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Cell Stem Cell. 2013;12:354-67 pubmed publisher

Dil mukhametova L, Pronina T, Ugriumov M. [Noradrenaline role in regulation of dopamine-producing neurons in rat arcuate nucleus]. Ross Fiziol Zh Im I M Sechenova. 2012;98:1507-19 pubmed

Wang Y, Wang X, Li R, Yang Z, Wang Y, Gong X, et al. A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons. CNS Neurosci Ther. 2013;19:183-90 pubmed publisher

Padovan Neto F, Ferreira N, de Oliveira Tavares D, de Aguiar D, da Silva C, Raisman Vozari R, et al. Anti-dyskinetic effect of the neuronal nitric oxide synthase inhibitor is linked to decrease of FosB/deltaFosB expression. Neurosci Lett. 2013;541:126-31 pubmed publisher

Jalali Nadoushan M, Roghani M. Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism. Brain Res. 2013;1505:68-74 pubmed publisher

Mansouri M, Farbood Y, Sameri M, Sarkaki A, Naghizadeh B, Rafeirad M. Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats. Food Chem. 2013;138:1028-33 pubmed publisher

Real C, Ferreira A, Chaves Kirsten G, Torrão A, Pires R, Britto L. BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease. Neuroscience. 2013;237:118-29 pubmed publisher

Ahmad A, Maruyama T, Narumiya S, DORE S. PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target. Neurotox Res. 2013;23:260-6 pubmed publisher

Thomas Tayra J, Kameda M, Yasuhara T, Agari T, Kadota T, Wang F, et al. The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease. Brain Res. 2013;1502:55-70 pubmed publisher

Abedi P, Delaville C, De Deurwaerdere P, Benjelloun W, Benazzouz A. Intrapallidal administration of 6-hydroxydopamine mimics in large part the electrophysiological and behavioral consequences of major dopamine depletion in the rat. Neuroscience. 2013;236:289-97 pubmed publisher

Heuer A, Lelos M, Kelly C, Torres E, Dunnett S. Dopamine-rich grafts alleviate deficits in contralateral response space induced by extensive dopamine depletion in rats. Exp Neurol. 2013;247:485-95 pubmed publisher

Kobylecki C, Crossman A, Ravenscroft P. Alternative splicing of AMPA receptor subunits in the 6-OHDA-lesioned rat model of Parkinson's disease and L-DOPA-induced dyskinesia. Exp Neurol. 2013;247:476-84 pubmed publisher

Haleagrahara N, Siew C, Ponnusamy K. Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats. J Toxicol Sci. 2013;38:25-33 pubmed

Kabuto H, Yamanushi T, Janjua N, Takayama F, Mankura M. Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model. J Oleo Sci. 2013;62:21-8 pubmed

Ribeiro R, Moreira E, Santos D, Colle D, dos Santos A, Peres K, et al. Probucol affords neuroprotection in a 6-OHDA mouse model of Parkinson's disease. Neurochem Res. 2013;38:660-8 pubmed publisher

Lin L, Meng T, Liu T, Zheng Z. Increased melatonin may play dual roles in the striata of a 6-hydroxydopamine model of Parkinson's disease. Life Sci. 2013;92:311-6 pubmed publisher

Chao O, Pum M, Huston J. The interaction between the dopaminergic forebrain projections and the medial prefrontal cortex is critical for memory of objects: implications for Parkinson's disease. Exp Neurol. 2013;247:373-82 pubmed publisher

Chotibut T, Apple D, Jefferis R, Salvatore M. Dopamine transporter loss in 6-OHDA Parkinson's model is unmet by parallel reduction in dopamine uptake. PLoS ONE. 2012;7:e52322 pubmed publisher

Barros Silva R, Santos N, Martins N, Ferreira D, Barbosa F, Oliveira Souza V, et al. Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats. Neuroscience. 2013;233:86-94 pubmed publisher

Kaddour H, Hamdi Y, Vaudry D, Basille M, Desrues L, Leprince J, et al. The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway. J Neurochem. 2013;125:620-33 pubmed publisher

Seeger Armbruster S, von Ameln Mayerhofer A. Short- and long-term unilateral 6-hydroxydopamine lesions in rats show different changes in characteristics of spontaneous firing of substantia nigra pars reticulata neurons. Exp Brain Res. 2013;224:15-24 pubmed publisher

Xu Y, Long L, Yan J, Wei L, Pan M, Gao H, et al. Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses. CNS Neurosci Ther. 2013;19:170-7 pubmed publisher

Grespi F, Melino G. P73 and age-related diseases: is there any link with Parkinson Disease?. Aging (Albany NY). 2012;4:923-31 pubmed

Lui N, Chen L, Yung W, Chan Y, Yung K. Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat Parkinsonism. PLoS ONE. 2012;7:e51294 pubmed publisher

Shalavadi M, Chandrashekhar V, Avinash S, Sowmya C, Ramkishan A. Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson's disease model. Indian J Pharmacol. 2012;44:737-43 pubmed publisher

Camp D, Loeffler D, Farrah D, Borneman J, LeWitt P. Cellular immune response to intrastriatally implanted allogeneic bone marrow stromal cells in a rat model of Parkinson's disease. J Neuroinflammation. 2009;6:17 pubmed publisher