chemical

COTI-2

HY-19896

10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg

99; 90; 160; 235; 350; 600 USD

COTI-2

Chemical

10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg

99; 90; 160; 235; 350; 600 USD

COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation [1] [2] [3] .

99.40%

Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.