chemical

Birinapant TL32711

HY-16591

10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg

128; 84; 144; 336; 600 USD

Birinapant TL32711

Chemical

10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg

128; 84; 144; 336; 600 USD

Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with K d s of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

99.36%

Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.