chemical

Alisertib MLN 8237

HY-10971

10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg

82; 72; 120; 290; 450; 850 USD

Alisertib MLN 8237

Chemical

10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg

82; 72; 120; 290; 450; 850 USD

Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor ( IC 50 =1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity [1] [2] [3] .

99.84%

Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.