chemical

Repotrectinib TPX-0005

HY-103022

10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg

132; 120; 210; 420; 590 USD

Repotrectinib TPX-0005

Chemical

10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg

132; 120; 210; 420; 590 USD

Repotrectinib (TPX-0005) is a potent ROS1 ( IC 50 =0.07 nM), TRK (0.83/0.05/0.1 nM=TRKA/B/C) inhibitor. Repotrectinib (TPX-0005) potently inhibits WT ALK (1.01 nM) and mutant ALKs including ALK G1202R (1.26 nM) and ALK L1196M (1.08 nM). It also inhibits a variety of other kinases, including JAK2, LYN, Src, and FAK (1.04, 1.66, 5.3, and 6.96 nM, respectively) [1] [2] .

99.91%

Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.