antibody

HSD17B1 Antibody

HY-P83303

10 μL;50 μL;100 μL

70;185;300 USD

recombinant

domestic rabbit

nonconjugated

YA3048

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

HSD17B1 Antibody

antibody

Rabbit

Recombinant, Monoclonal

Non-conjugated

YA3048

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human

The related gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. The related gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in The related gene have been linked to breast and prostate cancer. A pseudorelated gene of The related gene has been identified. Alternative splicing results in multiple transcript variants.

hydroxysteroid (17-beta) dehydrogenase 1; HSD17; EDHB17; EDH17B2; SDR28C1

A synthetic peptide of human HSD17B1

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

WB, IHC-F, IHC-P, ICC/IF, IP

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.