antibody

HLA B Antibody

HY-P82867

10 μL;50 μL;100 μL

70;185;300 USD

recombinant

domestic rabbit

nonconjugated

YA2612

western blot, immunohistochemistry - paraffin section

HLA B Antibody

antibody

Rabbit

Recombinant, Monoclonal

Non-conjugated

YA2612

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human

HLA-B belongs to the HLA class I heavy chain paralogues. The class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its related gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

HLA B; HLAB

A synthesized peptide derived from human HLA B7

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

WB, IHC-P

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.