antibody

Kaiso Antibody

HY-P82798

10 μL;50 μL;100 μL

75;190;310 USD

recombinant

domestic rabbit

nonconjugated

YA2543

Kaiso Antibody

antibody

Rabbit

Recombinant, Monoclonal

Non-conjugated

YA2543

10 μL;50 μL;100 μL

75;190;310 USD

Primary Antibodies

Human, Mouse, Rat

The related gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target related gene promoters. It may contribute to the repression of target related genes of the Wnt signaling pathway, and may also activate transcription of a subset of target related genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin- 2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of The protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Kaiso; Zbtb33; ZNF Kaiso; ZNF348

A synthesized peptide derived from human KAISO

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

WB

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.