antibody

Niemann Pick C1 Antibody

HY-P82545

10 μL;50 μL;100 μL

70;185;300 USD

recombinant

domestic rabbit

nonconjugated

YA2290

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

Niemann Pick C1 Antibody

antibody

Rabbit

Recombinant, Monoclonal

Non-conjugated

YA2290

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human, Mouse, Rat

The related gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. The protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in The related gene cause Niemann-Pick type C disease, a rare autosomal recessive neuroderelated generative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Niemann Pick C1 protein precursor; NPC; NPC1

A synthesized peptide derived from human Niemann Pick C1

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

WB, IHC-P, ICC/IF, FC

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.