antibody

SH2D1A Antibody

HY-P82205

10 μL;50 μL;100 μL

65;175;275 USD

recombinant

domestic rabbit

nonconjugated

YA1950

SH2D1A Antibody

antibody

Rabbit

Recombinant, Monoclonal

Non-conjugated

YA1950

10 μL;50 μL;100 μL

65;175;275 USD

Primary Antibodies

Human, Mouse, Rat

The related gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. The protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of The transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. The protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in The related gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for The related gene.

LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A

A synthetic peptide of human SH2D1A/SAP

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

WB

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.