antibody

PTP1B Antibody

HY-P82031

10 μL;50 μL;100 μL

70;185;300 USD

recombinant

domestic rabbit

nonconjugated

YA1776

western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

PTP1B Antibody

antibody

Rabbit

Recombinant, Monoclonal

Non-conjugated

YA1776

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human

The protein encoded by The related gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. The PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. The PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of The PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for The related gene.

PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B

A synthetic peptide of human PTP1B

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

WB, IHC-F, IHC-P, ICC/IF

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.