Phospho-MLKL | MedChem Express LLC HY-P81878 product information

product summary

company name :

MedChem Express LLC

product type :

antibody

product name :

Phospho-MLKL

catalog :

HY-P81878

quantity :

10 μL;50 μL;100 μL

price :

75;190;310 USD

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

YA1623

reactivity :

human

application :

western blot, immunohistochemistry - paraffin section

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P81878

Product Name :

Phospho-MLKL

Product Type :

antibody

Host Species :

Rabbit

Clonality :

Recombinant, Monoclonal

Conjugation :

Non-conjugated

Clone Name :

YA1623

Size :

10 μL;50 μL;100 μL

List Price :

75;190;310 USD

Product Description :

Primary Antibodies

CrossReactivity :

Human

Background :

The related gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. The protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of The related gene inhibited TNF-induced necrosis. High levels of The protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for The related gene.

ALTnames :

MLKL

Immunogen :

A synthesized peptide derived from human Phospho-MLKL (S358)

Buffer :

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Application Summary :

WB, IHC-P

Storage :

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

more info or order :

MedChem Express LLC product webpage