product summary
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company name :
MedChem Express LLC
product type :
antibody
product name :
SDHB Antibody
catalog :
HY-P81835
quantity :
10 μL;50 μL;100 μL
price :
70;185;300 USD
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
YA1580
reactivity :
human
application :
western blot, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
product information
Catalog Number :
HY-P81835
Product Name :
SDHB Antibody
Product Type :
antibody
Host Species :
Rabbit
Clonality :
Recombinant, Monoclonal
Conjugation :
Non-conjugated
Clone Name :
YA1580
Size :
10 μL;50 μL;100 μL
List Price :
70;185;300 USD
Product Description :
Primary Antibodies
CrossReactivity :
Human, Mouse, Rat
Background :
The tumor suppressor related gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. The enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in The related gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorirelated genesis. Mutations in The related gene are also implicated in nuclear type 4 mitochondrial complex II deficiency.
ALTnames :
SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit; mitochondrial; Iron-sulfur subunit of complex II; Ip
Immunogen :
A synthesized peptide derived from human SDHB
Buffer :
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Application Summary :
WB, IHC-P, IP, FC
Storage :
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA