antibody

XBP1 Antibody

HY-P81679

10 μL;50 μL;100 μL

70;185;300 USD

recombinant

domestic rabbit

nonconjugated

YA1424

western blot, immunoprecipitation

XBP1 Antibody

antibody

Rabbit

Monoclonal, Recombinant

Non-conjugated

YA1424

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human, Mouse

The related gene encodes a transcription factor that regulates MHC class II related genes by binding to a promoter element referred to as an X box. The related gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of The related gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target related genes during the recovery phase of ER stress. A pseudorelated gene of XBP1 has been identified and localized to chromosome 5.

XBP1; TREB5; XBP2; X-box-binding protein 1; XBP-1; Tax-responsive element-binding protein 5

Recombinant protein of human XBP1

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

WB, IP

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.