antibody

Ionotropic Glutamate Receptor 2 Antibody

HY-P81398

10 μL;50 μL;100 μL

70;185;300 USD

recombinant

domestic rabbit

nonconjugated

YA1143

Ionotropic Glutamate Receptor 2 Antibody

antibody

Rabbit

Recombinant, Monoclonal

Non-conjugated

YA1143

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The related gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by The related gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for The related gene.

GRIA2; GLUR2; Glutamate receptor 2; GluR-2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic; AMPA 2; GluA2

Recombinant protein of human Glutamate receptor 2

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.139.

IHC-P

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.