antibody

RANKL/CD254 Antibody

HY-P81124

10 μL;50 μL;100 μL

70;185;300 USD

polyclonal

domestic rabbit

nonconjugated

western blot, ELISA, immunohistochemistry - paraffin section

RANKL/CD254 Antibody

antibody

Rabbit

Polyclonal

Non-conjugated

10 μL;50 μL;100 μL

70;185;300 USD

Polyclonal Antibodies

Human, Mouse, Rat

The related gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. The protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of The related gene and lead to an increase of osteoclastorelated genesis and bone loss. The protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated The protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.

KLH conjugated synthetic peptide derived from human OPGL: 21/-317/317

Cytoplasm; Secreted and Cell membrane.

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

WB, IHC-P, ELISA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.