antibody

DLAT Antibody

HY-P81070

10 μL;50 μL;100 μL

70;185;300 USD

monoclonal

mouse

nonconjugated

YA912

western blot, immunocytochemistry, immunoprecipitation

DLAT Antibody

antibody

Mouse

Monoclonal

Non-conjugated

YA912

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human, Mouse

The related gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of The related gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where The protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in The related gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

DLAT; DLTA; E2; PBC; PDCE2; Pyruvate Dehydrogenase E2

Purified recombinant human Pyruvate Dehydrogenase E2 protein fragments expressed in E.coli.

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

WB, ICC/IF, IP

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.