antibody

MUC16 Antibody

HY-P81044

10 μL;50 μL;100 μL

70;180;285 USD

recombinant

nonconjugated

YA890

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

MUC16 Antibody

antibody

Recombinant, Monoclonal

Non-conjugated

YA890

10 μL;50 μL;100 μL

70;180;285 USD

Primary Antibodies

Human

The related gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. The protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of The related gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.

MUC16; CA125; Mucin-16; MUC-16; Ovarian cancer-related tumor marker CA125; CA-125; Ovarian carcinoma antigen CA125

Recombinant protein within Human MUC16 aa 12331-12339 / 14,5/7.

Cell membrane, extracellular space.

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

WB, ICC/IF, IHC-P, FC

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.