antibody

Toll-Like Receptor 4 Antibody

HY-P80918

10 μL;50 μL;100 μL

110;290;460 USD

polyclonal

domestic rabbit

nonconjugated

western blot, flow cytometry

Toll-Like Receptor 4 Antibody

antibody

Rabbit

Polyclonal Antibody

Unconjugated

10 μL;50 μL;100 μL

110;290;460 USD

Primary Antibodies

Human

Toll-Like Receptor 4: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

TLR4; Toll-like receptor 4; hToll; CD antigen CD284

Synthetic peptide corresponding to Human TLR4.AA range:669-698.

Supplied in 1*PBS (pH 7.3). Preservative: 0.09% sodium azide or 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

WB, FC

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.