antibody

RPA70 Antibody

HY-P80884

10 μL;50 μL;100 μL

70;185;300 USD

monoclonal

mouse

nonconjugated

YA678

western blot, immunocytochemistry, immunoprecipitation

RPA70 Antibody

antibody

Mouse

Monoclonal Antibody

Unconjugated

YA678

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human, Monkey, Mouse, Rat

RPA70 (8C3): This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]

RPA1; HSSB; MST075; REPA1; RF-A; RP-A; RPA70

Synthetic peptide corresponding to Human RPA70.The exact sequence is proprietary to MCE.

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

WB, ICC/IF, IP

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.