Phospho-Smad2 Antibody | MedChem Express LLC HY-P80853 product information

product summary

company name :

MedChem Express LLC

product type :

antibody

product name :

Phospho-Smad2 Antibody

catalog :

HY-P80853

quantity :

10 μL;50 μL;100 μL

price :

70;185;300 USD

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

YA152

reactivity :

human

application :

western blot

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P80853

Product Name :

Phospho-Smad2 Antibody

Product Type :

antibody

Host Species :

Rabbit

Clonality :

Monoclonal Antibody

Conjugation :

Unconjugated

Clone Name :

YA152

Size :

10 μL;50 μL;100 μL

List Price :

70;185;300 USD

Product Description :

Primary Antibodies

CrossReactivity :

Human, Mouse, Rat, Hamster

Background :

Smad2: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

ALTnames :

SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2

Immunogen :

Synthetic phosphopeptide corresponding to residues surrounding Ser250 of Human Smad2.The exact sequence is proprietary to MCE.

Buffer :

Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% Sodium azide

Application Summary :

Storage :

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

more info or order :

MedChem Express LLC product webpage