antibody

JAK1 Antibody

HY-P80726

10 μL;50 μL;100 μL

70;185;300 USD

monoclonal

mouse

nonconjugated

YA722

western blot, immunocytochemistry, immunoprecipitation

JAK1 Antibody

antibody

Mouse

Monoclonal Antibody

Unconjugated

YA722

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human, Rat

JAK1 (8B8): This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]

JAK1; JAK1A; JAK1B; Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1

Synthetic peptide corresponding to Human Jak1.The exact sequence is proprietary to MCE.

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

WB, ICC/IF, IP

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.