IL-4 Antibody | MedChem Express LLC HY-P80722 product information

product summary

company name :

MedChem Express LLC

product type :

antibody

product name :

IL-4 Antibody

catalog :

HY-P80722

quantity :

10 μL;50 μL;100 μL

price :

70;185;300 USD

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

YA343

reactivity :

human

application :

western blot

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P80722

Product Name :

IL-4 Antibody

Product Type :

antibody

Host Species :

Rabbit

Clonality :

Monoclonal Antibody

Conjugation :

Unconjugated

Clone Name :

YA343

Size :

10 μL;50 μL;100 μL

List Price :

70;185;300 USD

Product Description :

Primary Antibodies

CrossReactivity :

Human, Mouse, Rat

Background :

IL-4: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]

ALTnames :

IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Immunogen :

Synthetic peptide corresponding to Human IL4.The exact sequence is proprietary to MCE.

Buffer :

Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% Sodium azide

Application Summary :

Storage :

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

more info or order :

MedChem Express LLC product webpage