antibody

FEN1 Antibody

HY-P80669

10 μL;50 μL;100 μL

70;185;300 USD

monoclonal

mouse

nonconjugated

YA765

western blot, immunoprecipitation

FEN1 Antibody

antibody

Mouse

Monoclonal Antibody

Unconjugated

YA765

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human, Mouse, Rat

FEN1 (1E7): The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1

Synthetic peptide corresponding to Human FEN-1.The exact sequence is proprietary to MCE.

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

WB, IP

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.