antibody

HER2 Antibody

HY-P80658

10 μL;50 μL;100 μL

65;165;260 USD

monoclonal

mouse

nonconjugated

YA771

western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

HER2 Antibody

antibody

Mouse

Monoclonal Antibody

Unconjugated

YA771

10 μL;50 μL;100 μL

65;165;260 USD

Primary Antibodies

Human, Mouse, Rat

HER2 (1C4): This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340

Synthetic peptide corresponding to ErbB 2.The exact sequence is proprietary to MCE.

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

WB, IHC-F, IHC-P, ICC/IF

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.