CDKN2A/p16INK4a Antibody | MedChem Express LLC HY-P80615 product information

product summary

company name :

MedChem Express LLC

product type :

antibody

product name :

CDKN2A/p16INK4a Antibody

catalog :

HY-P80615

quantity :

10 μL;50 μL;100 μL

price :

70;185;300 USD

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

YA508

reactivity :

human

application :

western blot, immunoprecipitation

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P80615

Product Name :

CDKN2A/p16INK4a Antibody

Product Type :

antibody

Host Species :

Rabbit

Clonality :

Monoclonal Antibody

Conjugation :

Unconjugated

Clone Name :

YA508

Size :

10 μL;50 μL;100 μL

List Price :

70;185;300 USD

Product Description :

Primary Antibodies

CrossReactivity :

Human, Mouse

Background :

CDKN2A: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

ALTnames :

CDK4 inhibitor p16 INK4 antibody; CDK4I antibody; CDKN2 antibody; CDKN2A antibody; Cell cycle negative regulator beta antibody; CMM2 antibody; Cyclin dependent kinase 4 inhibitor A antibody; Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody; Cyclin Dependent Kinase Inhibitor 2A antibody; Cyclin dependent kinase inhibitor 2A isoform 4 antibody; Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody; Cyclin dependent kinase inhibitor p16 antibody; INK4 antibody; INK4A antibody; MLM antibody; MTS1 antibody; Multiple tumor suppressor 1 antibody; p14 antibody; p16 antibody; P16INK4 antibody; p16INK4a antibody; p19 antibody; p19Arf antibody; TP16 antibody;

Immunogen :

Synthetic peptide corresponding to Human CDKN2A/p16INK4a.The exact sequence is proprietary to MCE.

Buffer :

Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% Sodium azide

Application Summary :

WB, IP

Storage :

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

more info or order :

MedChem Express LLC product webpage