CD19 Antibody | MedChem Express LLC HY-P80597 product information

product summary

company name :

MedChem Express LLC

product type :

antibody

product name :

CD19 Antibody

catalog :

HY-P80597

quantity :

10 μL;50 μL;100 μL

price :

70;185;300 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

YA807

reactivity :

human

application :

immunocytochemistry, flow cytometry

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P80597

Product Name :

CD19 Antibody

Product Type :

antibody

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Non-conjugated

Clone Name :

YA807

Size :

10 μL;50 μL;100 μL

List Price :

70;185;300 USD

Product Description :

Primary Antibodies

CrossReactivity :

Human

Background :

CD19 (3G7): This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]

ALTnames :

CD19; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD19

Immunogen :

Synthetic peptide corresponding to Human CD19.The exact sequence is proprietary to MCE.

Buffer :

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

Application Summary :

ICC/IF, FC

Storage :

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

more info or order :

MedChem Express LLC product webpage