antibody

BRCA1 Antibody

HY-P80573

10 μL;50 μL;100 μL

70;185;300 USD

polyclonal

domestic rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

BRCA1 Antibody

antibody

Rabbit

Polyclonal Antibody

Unconjugated

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human, Rat

BRCA1: This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53

Synthetic peptide corresponding to Human BRCA1.AA range:1391-1440.

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

WB, IHC-F, IHC-P, ICC/IF, ELISA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.