antibody

ATF6 Antibody

HY-P80554

10 μL;50 μL;100 μL

70;185;300 USD

monoclonal

domestic rabbit

nonconjugated

YA604

western blot, immunoprecipitation, immunohistochemistry - paraffin section

ATF6 Antibody

antibody

Rabbit

Monoclonal Antibody

Unconjugated

YA604

10 μL;50 μL;100 μL

70;185;300 USD

Primary Antibodies

Human

ATF6: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

activating transcription factor 6; ATF6A

Synthetic peptide corresponding to Human ATF6.The exact sequence is proprietary to MCE.

Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% Sodium azide

WB, IHC-P, IP

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.