protein

FABP5 Protein, Mouse (His)

HY-P79398

5 μg;10 μg;50 μg;100 μg;500 μg

69;116;325;553;1550 USD

FABP5 Protein, Mouse (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg

69;116;325;553;1550 USD

472439250

FABP5, also known as E-FABP, acts as an intracellular carrier of long-chain fatty acids and related lipids and regulates ligand metabolism.In addition to cytoplasmic transport, it selectively transports fatty acids to the nucleus, activates nuclear receptors, and delivers retinoic acid to promote proliferation.FABP5 Protein, Mouse (His) is the recombinant mouse-derived FABP5 protein, expressed by E.coli , with N-6*His labeled tag.

Mouse

FABP5, also known as E-FABP, functions as an intracellular carrier for long-chain fatty acids and related active lipids, including endocannabinoids, thereby regulating the metabolism and actions of the ligands they bind. Beyond its role in cytosolic transport, FABP5 selectively delivers specific fatty acids from the cytosol to the nucleus, activating nuclear receptors. Notably, it delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta, promoting proliferation and survival. FABP5's involvement extends to serving as a synaptic carrier of endocannabinoids at central synapses, thereby controlling retrograde endocannabinoid signaling. Additionally, FABP5 modulates inflammation by regulating PTGES induction through NF-kappa-B activation and prostaglandin E2 (PGE2) biosynthesis during inflammatory processes. Its potential role in keratinocyte differentiation is also suggested.

Fatty acid-binding protein 5; Fabp5; Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein, epidermal; Keratinocyte lipid-binding protein; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; Fabpe; Klbp; Mal1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.