protein

Lgr5/GPR49 Protein, Human (CHO, hFc)

HY-P79308

5 μg;10 μg

43;74 USD

Lgr5/GPR49 Protein, Human (CHO, hFc)

proteins

CHO

5 μg;10 μg

43;74 USD

The Lgr5/GPR49 protein is a receptor for R-spondins that enhances the canonical Wnt signaling pathway and marks stem cells in the intestinal epithelium and hair follicles. Lgr5/GPR49 binds R-spondins (RSPO1-4), binds to phosphorylated LRP6 and Frizzled receptors, initiates Wnt signaling and amplifies target gene expression. Lgr5/GPR49 Protein, Human (CHO, hFc) is the recombinant human-derived Lgr5/GPR49 protein, expressed by CHO , with C-hFc labeled tag. The total length of Lgr5/GPR49 Protein, Human (CHO, hFc) is 539 a.a., with molecular weight of 88-110 kDa.

Human

The Lgr5/GPR49 Protein serves as the receptor for R-spondins, functioning to potentiate the canonical Wnt signaling pathway while concurrently serving as a distinctive stem cell marker in the intestinal epithelium and hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3, or RSPO4), Lgr5/GPR49 associates with phosphorylated LRP6 and frizzled receptors activated by extracellular Wnt, initiating the canonical Wnt signaling pathway and amplifying the expression of target genes. In contrast to classical G-protein coupled receptors, Lgr5/GPR49 does not activate heterotrimeric G-proteins to transduce the signal, highlighting its unique regulatory role in Wnt signaling. It plays a crucial role in the development and maintenance of adult intestinal stem cells during postembryonic development and has been identified in a complex with RNF43 and RSPO1. Additionally, Lgr5/GPR49 interacts with other R-spondin ligands, including RSPO2, RSPO3, and RSPO4, emphasizing its diverse participation in cellular signaling pathways.

Leucine-rich repeat-containing G-protein coupled receptor 5; LGR5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GPR49; GPR67; Leucine-rich Repeat Containing G Protein-coupled Receptor 5

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.