protein

Agrin Protein, Human (CHO, His)

HY-P79236

10 μg;50 μg;100 μg;500 μg

125;350;590;1500 USD

Agrin Protein, Human (CHO, His)

proteins

CHO

10 μg;50 μg;100 μg;500 μg

125;350;590;1500 USD

Agrin is critical for neuromuscular junction development and was discovered in mouse knockout studies. It contains laminin G, Kazal-type serpin, and epidermal growth factor domains. Agrin Protein, Human (CHO, His) is the recombinant human-derived Agrin protein, expressed by CHO , with N-6*His labeled tag.

Human

The Agrin protein, an essential component in the development of the neuromuscular junction (NMJ), has been identified through knockout studies in mice. It encompasses laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additionally, post-translational modifications occur, including the addition of glycosaminoglycans and disulfide bonds. Notably, a mutation in this gene has been associated with congenital myasthenic syndrome affecting limb-girdle muscles in a specific family. Alternative splicing gives rise to multiple transcript variants that encode different isoforms. This protein exhibits a broad expression pattern, with notable presence in kidney, lung, and 21 other tissues.

agrin proteoglycan; Agrin; AGRN

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.