protein

Furin/PCSK3 Protein, Mouse (HEK293, His)

HY-P79228

5 μg;10 μg;50 μg

182;310;868 USD

Furin/PCSK3 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

182;310;868 USD

Furin/PCSK3 protein is an endoprotease with RX(K/R)R cleavage activity and is widely expressed in the constitutive secretory pathway.It plays a crucial role in processing various substrates, including TGFB1, and activating TGF-β-1.Furin/PCSK3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Furin/PCSK3 protein, expressed by HEK293 , with C-10*His labeled tag.

Mouse

Furin/PCSK3 protein is a widely expressed endoprotease present in constitutive secretory pathways that exhibits cleavage activity at the RX(K/R)R consensus motif. It plays a crucial role in the processing of various substrates, including TGFB1, contributing to the activation of TGF-beta-1. Additionally, Furin/PCSK3 protein is responsible for converting the non-functional prohormone Brain natriuretic factor into its active hormone BNP(1-45) through proteolytic cleavage. Moreover, it regulates the acidification of dense-core secretory granules in islets of Langerhans cells by mediating the processing of the accessory subunit ATP6AP1/Ac45 of the V-ATPase.

Furin; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE; Prohormone convertase 3; Fur; Pcsk3

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, 1 mM 2 , 0.5% (w/v) Brij-35, pH 7.4.

Room temperature in continental US; may vary elsewhere.