protein

Heparinase II Protein, P. heparinus (His)

HY-P79221

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

188;300;840;1345;3500;5600 USD

Heparinase II Protein, P. heparinus (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

188;300;840;1345;3500;5600 USD

Heparinase II protein is an enzyme that cleaves heparin and heparan sulfate glycosaminoglycans using a beta elimination mechanism. Specifically, it cleaves heparin at the α-D-GlcNp2S6S(1->4) α-L-IdoAp2S site and at the α-D-GlcNp2Ac(or 2S)6OH(1->4)beta-D-GlcAp position Site of cleavage of heparan sulfate. Heparinase II Protein, P. heparinus (His) is the recombinant Heparinase II protein, expressed by E. coli , with N-His labeled tag. The total length of Heparinase II Protein, P. heparinus (His) is 747 a.a., with molecular weight of 66-75 kDa.

Others

Heparinase II is a protein with the remarkable ability to cleave both heparin and heparan sulfate glycosaminoglycans using a beta-elimination mechanism. This enzymatic process involves the cleavage of heparin at alpha-D-GlcNp2S6S(1->4) alpha-L-IdoAp2S and heparan sulfate at alpha-D-GlcNp2Ac(or 2S)6OH(1->4)beta-D-GlcAp. By catalyzing these specific cleavage reactions, Heparinase II plays a crucial role in the structural modification and degradation of these complex glycosaminoglycans. The enzyme's ability to target distinct glycosidic linkages in heparin and heparan sulfate makes it a valuable tool in the study of these polysaccharides, contributing to our understanding of their biological functions and potential therapeutic applications (

Heparinase II

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS.

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