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company name :
MedChem Express LLC
product type :
protein
product name :
IL-18/IL-1F4 Protein, Porcine
catalog :
HY-P79202
quantity :
5 μg;10 μg;50 μg;100 μg;1 mg
price :
88;140;400;640;2865 USD
more info or order :
product information
Catalog Number :
HY-P79202
Product Name :
IL-18/IL-1F4 Protein, Porcine
Product Type :
proteins
Host Species :
E. coli
Size :
5 μg;10 μg;50 μg;100 μg;1 mg
List Price :
88;140;400;640;2865 USD
Product Description :
IL-18/IL-1F4 protein is a pro-inflammatory cytokine that is critical in epithelial barrier repair and coordinates immune responses involving Th1 cells and NK cells. IL-18 binds to IL18R1 and IL18RAP to form a ternary complex that activates NF-κ-B and triggers the synthesis of inflammatory mediators. IL-18/IL-1F4 Protein, Porcine is the recombinant Porcine-derived IL-18/IL-1F4 protein, expressed by E. coli , with tag free. The total length of IL-18/IL-1F4 Protein, Porcine is 157 a.a., with molecular weight of ~18.0 kDa.
SpeciesSummary :
Porcine
Background :
IL-18, a pro-inflammatory cytokine, plays a crucial role in epithelial barrier repair and orchestrates polarized immune responses involving T-helper 1 (Th1) cells and natural killer (NK) cells. Upon binding to IL18R1 and IL18RAP, IL-18 forms a signaling ternary complex that activates NF-kappa-B, triggering the synthesis of inflammatory mediators. It synergizes with IL-12 to induce IFNG synthesis in Th1 cells and NK cells. Notably, IL-18 is involved in the transduction of inflammation downstream of pyroptosis, where its mature form is specifically released into the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. At the plasma membrane, IL-18 forms a ternary complex with the ligand-binding receptor subunit IL18R1 and the signaling receptor subunit IL18RAP, initiating intracellular signaling. The interaction with the cargo receptor TMED10 facilitates IL-18's translocation from the cytoplasm into the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and subsequent secretion.
ALTnames :
Interleukin-18; IL-18; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; IGIF; Interleukin 18
Purity :
Greater than 95% as determined by reducing SDS-PAGE
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 2 mM DTT, 8% trehalose.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA